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Protein

Renal cancer differentiation gene 1 protein

Gene

C4orf46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Renal cancer differentiation gene 1 protein1 Publication
Gene namesi
Name:C4orf46
Synonyms:RCDG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:27320. C4orf46.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379968.

Polymorphism and mutation databases

DMDMi74740214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Renal cancer differentiation gene 1 proteinPRO_0000335689Add
BLAST

Proteomic databases

EPDiQ504U0.
MaxQBiQ504U0.
PaxDbiQ504U0.
PRIDEiQ504U0.

PTM databases

PhosphoSiteiQ504U0.

Expressioni

Tissue specificityi

Expressed in the kidney, in epithelial cells in both proximal tubules and distal convoluted tubules.1 Publication

Gene expression databases

BgeeiQ504U0.
CleanExiHS_C4orf46.
ExpressionAtlasiQ504U0. baseline and differential.
GenevisibleiQ504U0. HS.

Organism-specific databases

HPAiHPA047287.
HPA052670.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDR2Q018503EBI-6657981,EBI-1181367
KXD1Q9BQD33EBI-6657981,EBI-739657
TFPTG5E9B53EBI-6657981,EBI-10178002

Protein-protein interaction databases

BioGridi128401. 7 interactions.
IntActiQ504U0. 4 interactions.
STRINGi9606.ENSP00000368503.

Structurei

3D structure databases

ProteinModelPortaliQ504U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J52F. Eukaryota.
ENOG4111AB8. LUCA.
GeneTreeiENSGT00390000003125.
HOGENOMiHOG000054226.
HOVERGENiHBG096306.
InParanoidiQ504U0.
OMAiMANPEGL.
OrthoDBiEOG779P1F.
PhylomeDBiQ504U0.
TreeFamiTF338687.

Family and domain databases

InterProiIPR031457. RCDG1.
[Graphical view]
PfamiPF15725. DUF4676. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q504U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPEELQVS SPPPPPPSSP SSSDASAASS PGGPVSLGWP VPSRSSGPTV
60 70 80 90 100
DQLEEVELQI GDAAFSLTKL LEATSAVSAQ VEELAFKCTE NARFLKTWRD
110
LLKEGYDSLK PDD
Length:113
Mass (Da):11,899
Last modified:June 7, 2005 - v1
Checksum:i6FE4325ED2C2CAB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027539 mRNA. Translation: BAG51339.1.
AK074948 mRNA. Translation: BAG52038.1.
CH471056 Genomic DNA. Translation: EAX04855.1.
BC065017 mRNA. Translation: AAH65017.1.
BC094775 mRNA. Translation: AAH94775.1.
CCDSiCCDS34088.1.
RefSeqiNP_001008394.1. NM_001008393.3.
UniGeneiHs.380920.
Hs.735449.

Genome annotation databases

EnsembliENST00000379205; ENSP00000368503; ENSG00000205208.
GeneIDi201725.
KEGGihsa:201725.
UCSCiuc003iqa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027539 mRNA. Translation: BAG51339.1.
AK074948 mRNA. Translation: BAG52038.1.
CH471056 Genomic DNA. Translation: EAX04855.1.
BC065017 mRNA. Translation: AAH65017.1.
BC094775 mRNA. Translation: AAH94775.1.
CCDSiCCDS34088.1.
RefSeqiNP_001008394.1. NM_001008393.3.
UniGeneiHs.380920.
Hs.735449.

3D structure databases

ProteinModelPortaliQ504U0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128401. 7 interactions.
IntActiQ504U0. 4 interactions.
STRINGi9606.ENSP00000368503.

PTM databases

PhosphoSiteiQ504U0.

Polymorphism and mutation databases

DMDMi74740214.

Proteomic databases

EPDiQ504U0.
MaxQBiQ504U0.
PaxDbiQ504U0.
PRIDEiQ504U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379205; ENSP00000368503; ENSG00000205208.
GeneIDi201725.
KEGGihsa:201725.
UCSCiuc003iqa.4. human.

Organism-specific databases

CTDi201725.
GeneCardsiC4orf46.
HGNCiHGNC:27320. C4orf46.
HPAiHPA047287.
HPA052670.
MIMi616210. gene.
neXtProtiNX_Q504U0.
PharmGKBiPA162379968.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J52F. Eukaryota.
ENOG4111AB8. LUCA.
GeneTreeiENSGT00390000003125.
HOGENOMiHOG000054226.
HOVERGENiHBG096306.
InParanoidiQ504U0.
OMAiMANPEGL.
OrthoDBiEOG779P1F.
PhylomeDBiQ504U0.
TreeFamiTF338687.

Miscellaneous databases

ChiTaRSiC4orf46. human.
GenomeRNAii201725.
NextBioi90195.
PROiQ504U0.
SOURCEiSearch...

Gene expression databases

BgeeiQ504U0.
CleanExiHS_C4orf46.
ExpressionAtlasiQ504U0. baseline and differential.
GenevisibleiQ504U0. HS.

Family and domain databases

InterProiIPR031457. RCDG1.
[Graphical view]
PfamiPF15725. DUF4676. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Placenta.
  4. "Expression and clinical significance of RCDG1 in renal cell carcinoma: a novel renal cancer-associated gene."
    Yu Z., Ni L., Chen D., Su Z., Yu W., Zhang Q., Wang Y., Li C., Gui Y., Lai Y.
    Mol. Med. Report. 10:1583-1589(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCD046_HUMAN
AccessioniPrimary (citable) accession number: Q504U0
Secondary accession number(s): B3KNH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 7, 2005
Last modified: March 16, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.