Q504T8 (MIDN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Midnolin

Alternative name(s):
Midbrain nucleolar protein

Gene names

Name:

MIDN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in regulation of genes related to neurogenesis in the nucleolus By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Midnolin		PRO_0000287536
Regions
	Domain	31 – 105	75	Ubiquitin-like
Experimental info
	Sequence conflict	457	1	V → A in AAH94778. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q504T8 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: E4086F3B6E16C4C2	FASTA	468	49,213
	10 20 30 40 50 60 MEPQPGGARS CRRGAPGGAC ELGPAAEAAP MSLAIHSTTG TRYDLAVPPD ETVEGLRKRL 70 80 90 100 110 120 SQRLKVPKER LALLHKDTRL SSGKLQEFGV GDGSKLTLVP TVEAGLMSQA SRPEQSVMQA 130 140 150 160 170 180 LESLTETQVS DFLSGRSPLT LALRVGDHMM FVQLQLAAQH APLQHRHVLA AAAAAAAARG 190 200 210 220 230 240 DPSIASPVSS PCRPVSSAAR VPPVPTSPSP ASPSPITAGS FRSHAASTTC PEQMDCSPTA 250 260 270 280 290 300 SSSASPGAST TSTPGASPAP RSRKPGAVIE SFVNHAPGVF SGTFSGTLHP NCQDSSGRPR 310 320 330 340 350 360 RDIGTILQIL NDLLSATRHY QGMPPSLAQL RCHAQCSPAS PAPDLAPRTT SCEKLTAAPS 370 380 390 400 410 420 ASLLQGQSQI RMCKPPGDRL RQTENRATRC KVERLQLLLQ QKRLRRKARR DARGPYHWSP 430 440 450 460 SRKAGRSDSS SSGGGGSPSE ASGLGLDFED SVWKPEVNPD IKSEFVVA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC015089 mRNA. Translation: AAH15089.2. BC094778 mRNA. Translation: AAH94778.1.
IPI	IPI00164432.
RefSeq	NP_796375.3. NM_177401.4.
UniGene	Hs.465529.
3D structure databases
ProteinModelPortal	Q504T8.
SMR	Q504T8. Positions 29-102.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000300952.
PTM databases
PhosphoSite	Q504T8.
Polymorphism databases
DMDM	296437369.
Proteomic databases
PaxDb	Q504T8.
PRIDE	Q504T8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300952; ENSP00000300952; ENSG00000167470. ENST00000591446; ENSP00000467679; ENSG00000167470.
GeneID	90007.
KEGG	hsa:90007.
UCSC	uc002lrp.3. human.
Organism-specific databases
CTD	90007.
GeneCards	GC19P001248.
HGNC	HGNC:16298. MIDN.
HPA	HPA042018. HPA049432.
MIM	606700. gene.
neXtProt	NX_Q504T8.
PharmGKB	PA30818.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86840.
HOGENOM	HOG000072693.
HOVERGEN	HBG098000.
InParanoid	Q504T8.
OMA	RMCKPPG.
OrthoDB	EOG49GKH5.
Gene expression databases
Bgee	Q504T8.
CleanEx	HS_MIDN.
Genevestigator	Q504T8.
Family and domain databases
InterPro	IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. [Graphical view]
Pfam	PF00240. ubiquitin. 1 hit. [Graphical view]
SMART	SM00213. UBQ. 1 hit. [Graphical view]
PROSITE	PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MIDN. human.
GenomeRNAi	90007.
NextBio	76474.
SOURCE	Search...

Entry information

Entry name

MIDN_HUMAN

Accession

Primary (citable) accession number: Q504T8
Secondary accession number(s): Q96BW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.