Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Midnolin

Gene

MIDN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.By similarity

GO - Molecular functioni

  • kinase binding Source: UniProtKB

GO - Biological processi

  • negative regulation of glucokinase activity Source: UniProtKB
  • negative regulation of insulin secretion Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Midnolin
Alternative name(s):
Midbrain nucleolar protein
Gene namesi
Name:MIDN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167470.12.
HGNCiHGNC:16298. MIDN.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167470.
PharmGKBiPA30818.

Polymorphism and mutation databases

BioMutaiMIDN.
DMDMi296437369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875361 – 468MidnolinAdd BLAST468

Proteomic databases

EPDiQ504T8.
PaxDbiQ504T8.
PeptideAtlasiQ504T8.
PRIDEiQ504T8.

PTM databases

iPTMnetiQ504T8.
PhosphoSitePlusiQ504T8.

Expressioni

Gene expression databases

BgeeiENSG00000167470.
CleanExiHS_MIDN.
ExpressionAtlasiQ504T8. baseline and differential.
GenevisibleiQ504T8. HS.

Organism-specific databases

HPAiHPA042018.
HPA049432.

Interactioni

Subunit structurei

Interacts with GCK; the interaction occurs preferentially at low glucose levels.1 Publication

GO - Molecular functioni

  • kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124652. 9 interactors.
IntActiQ504T8. 5 interactors.
MINTiMINT-6775185.
STRINGi9606.ENSP00000300952.

Structurei

3D structure databases

ProteinModelPortaliQ504T8.
SMRiQ504T8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 105Ubiquitin-likePROSITE-ProRule annotationAdd BLAST75

Phylogenomic databases

eggNOGiENOG410IE7U. Eukaryota.
ENOG410XNUB. LUCA.
GeneTreeiENSGT00510000049027.
HOGENOMiHOG000072693.
HOVERGENiHBG098000.
InParanoidiQ504T8.
OMAiMCKPPGD.
OrthoDBiEOG091G0X8V.
PhylomeDBiQ504T8.
TreeFamiTF329735.

Family and domain databases

InterProiView protein in InterPro
IPR029071. Ubiquitin-like_domsf.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF00240. ubiquitin. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q504T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQPGGARS CRRGAPGGAC ELGPAAEAAP MSLAIHSTTG TRYDLAVPPD
60 70 80 90 100
ETVEGLRKRL SQRLKVPKER LALLHKDTRL SSGKLQEFGV GDGSKLTLVP
110 120 130 140 150
TVEAGLMSQA SRPEQSVMQA LESLTETQVS DFLSGRSPLT LALRVGDHMM
160 170 180 190 200
FVQLQLAAQH APLQHRHVLA AAAAAAAARG DPSIASPVSS PCRPVSSAAR
210 220 230 240 250
VPPVPTSPSP ASPSPITAGS FRSHAASTTC PEQMDCSPTA SSSASPGAST
260 270 280 290 300
TSTPGASPAP RSRKPGAVIE SFVNHAPGVF SGTFSGTLHP NCQDSSGRPR
310 320 330 340 350
RDIGTILQIL NDLLSATRHY QGMPPSLAQL RCHAQCSPAS PAPDLAPRTT
360 370 380 390 400
SCEKLTAAPS ASLLQGQSQI RMCKPPGDRL RQTENRATRC KVERLQLLLQ
410 420 430 440 450
QKRLRRKARR DARGPYHWSP SRKAGRSDSS SSGGGGSPSE ASGLGLDFED
460
SVWKPEVNPD IKSEFVVA
Length:468
Mass (Da):49,213
Last modified:May 18, 2010 - v2
Checksum:iE4086F3B6E16C4C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti457V → A in AAH94778 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015089 mRNA. Translation: AAH15089.2.
BC094778 mRNA. Translation: AAH94778.1.
CCDSiCCDS32864.1.
RefSeqiNP_796375.3. NM_177401.4.
UniGeneiHs.465529.

Genome annotation databases

EnsembliENST00000300952; ENSP00000300952; ENSG00000167470.
ENST00000591446; ENSP00000467679; ENSG00000167470.
GeneIDi90007.
KEGGihsa:90007.
UCSCiuc002lrp.4. human.

Similar proteinsi

Entry informationi

Entry nameiMIDN_HUMAN
AccessioniPrimary (citable) accession number: Q504T8
Secondary accession number(s): Q96BW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: November 22, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot