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Protein

C-type lectin domain family 12 member A

Gene

Clec12a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 12 member A
Alternative name(s):
C-type lectin-like molecule 1
Short name:
CLL-1
Myeloid inhibitory C-type lectin-like receptor
Short name:
MICL
Gene namesi
Name:Clec12a
Synonyms:Micl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3040968. Clec12a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini65 – 267ExtracellularSequence analysisAdd BLAST203

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003135791 – 267C-type lectin domain family 12 member AAdd BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161 ↔ 246By similarity
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi225 ↔ 238By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ504P2.
PaxDbiQ504P2.
PRIDEiQ504P2.

PTM databases

iPTMnetiQ504P2.
PhosphoSitePlusiQ504P2.

Expressioni

Gene expression databases

CleanExiMM_CLEC12A.

Interactioni

Subunit structurei

Interacts with PTPN6 and PTPN11.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063627.

Structurei

3D structure databases

ProteinModelPortaliQ504P2.
SMRiQ504P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 247C-type lectinAdd BLAST108

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 10ITIM motif6

Domaini

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000111777.
HOVERGENiHBG107715.
InParanoidiQ504P2.
KOiK17516.
PhylomeDBiQ504P2.
TreeFamiTF336674.

Family and domain databases

CDDicd03593. CLECT_NK_receptors_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link_sf.
IPR016187. CTDL_fold.
IPR033992. NKR-like_CTLD.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.

Sequencei

Sequence statusi: Complete.

Q504P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEIVYANL KIQDPDKKEE TQKSDKCGGK VSADASHSQQ KTVLILILLC
60 70 80 90 100
LLLFIGMGVL GGIFYTTLAT EMIKSNQLQR AKEELQENVF LQLKHNLNSS
110 120 130 140 150
KKIKNLSAML QSTATQLCRE LYSKEPEHKC KPCPKGSEWY KDSCYSQLNQ
160 170 180 190 200
YGTWQESVMA CSARNASLLK VKNKDVLEFI KYKKLRYFWL ALLPRKDRTQ
210 220 230 240 250
YPLSEKMFLS EESERSTDDI DKKYCGYIDR VNVYYTYCTD ENNIICEETA
260
SKVQLESVLN GLPEDSR
Length:267
Mass (Da):30,757
Last modified:June 7, 2005 - v1
Checksum:i2958572936E4A35D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90F → S in BAC39163 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084335 mRNA. Translation: BAC39163.1.
BC094904 mRNA. Translation: AAH94904.1.
CCDSiCCDS20584.1.
RefSeqiNP_808354.1. NM_177686.4.
XP_011239625.1. XM_011241323.2.
UniGeneiMm.90241.

Genome annotation databases

GeneIDi232413.
KEGGimmu:232413.
UCSCiuc009efl.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCL12A_MOUSE
AccessioniPrimary (citable) accession number: Q504P2
Secondary accession number(s): Q8BN96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 7, 2005
Last modified: November 22, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot