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Protein

C-type lectin domain family 12 member A

Gene

Clec12a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 12 member A
Alternative name(s):
C-type lectin-like molecule 1
Short name:
CLL-1
Myeloid inhibitory C-type lectin-like receptor
Short name:
MICL
Gene namesi
Name:Clec12a
Synonyms:Micl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3040968. Clec12a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicSequence analysisAdd
BLAST
Transmembranei44 – 6421Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini65 – 267203ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267C-type lectin domain family 12 member APRO_0000313579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence analysis
Disulfide bondi161 ↔ 246By similarity
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi225 ↔ 238By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ504P2.
PaxDbiQ504P2.
PRIDEiQ504P2.

PTM databases

iPTMnetiQ504P2.
PhosphoSiteiQ504P2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053063.
CleanExiMM_CLEC12A.

Interactioni

Subunit structurei

Interacts with PTPN6 and PTPN11.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063627.

Structurei

3D structure databases

ProteinModelPortaliQ504P2.
SMRiQ504P2. Positions 127-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 247108C-type lectinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi5 – 106ITIM motif

Domaini

Sequence similaritiesi

Contains 1 C-type lectin domain.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000111777.
HOVERGENiHBG107715.
InParanoidiQ504P2.
KOiK17516.
PhylomeDBiQ504P2.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.

Sequencei

Sequence statusi: Complete.

Q504P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEIVYANL KIQDPDKKEE TQKSDKCGGK VSADASHSQQ KTVLILILLC
60 70 80 90 100
LLLFIGMGVL GGIFYTTLAT EMIKSNQLQR AKEELQENVF LQLKHNLNSS
110 120 130 140 150
KKIKNLSAML QSTATQLCRE LYSKEPEHKC KPCPKGSEWY KDSCYSQLNQ
160 170 180 190 200
YGTWQESVMA CSARNASLLK VKNKDVLEFI KYKKLRYFWL ALLPRKDRTQ
210 220 230 240 250
YPLSEKMFLS EESERSTDDI DKKYCGYIDR VNVYYTYCTD ENNIICEETA
260
SKVQLESVLN GLPEDSR
Length:267
Mass (Da):30,757
Last modified:June 7, 2005 - v1
Checksum:i2958572936E4A35D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901F → S in BAC39163 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084335 mRNA. Translation: BAC39163.1.
BC094904 mRNA. Translation: AAH94904.1.
CCDSiCCDS20584.1.
RefSeqiNP_808354.1. NM_177686.4.
XP_011239625.1. XM_011241323.1.
UniGeneiMm.90241.

Genome annotation databases

GeneIDi232413.
KEGGimmu:232413.
UCSCiuc009efl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084335 mRNA. Translation: BAC39163.1.
BC094904 mRNA. Translation: AAH94904.1.
CCDSiCCDS20584.1.
RefSeqiNP_808354.1. NM_177686.4.
XP_011239625.1. XM_011241323.1.
UniGeneiMm.90241.

3D structure databases

ProteinModelPortaliQ504P2.
SMRiQ504P2. Positions 127-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063627.

PTM databases

iPTMnetiQ504P2.
PhosphoSiteiQ504P2.

Proteomic databases

MaxQBiQ504P2.
PaxDbiQ504P2.
PRIDEiQ504P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi232413.
KEGGimmu:232413.
UCSCiuc009efl.2. mouse.

Organism-specific databases

CTDi160364.
MGIiMGI:3040968. Clec12a.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000111777.
HOVERGENiHBG107715.
InParanoidiQ504P2.
KOiK17516.
PhylomeDBiQ504P2.
TreeFamiTF336674.

Miscellaneous databases

PROiQ504P2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053063.
CleanExiMM_CLEC12A.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCL12A_MOUSE
AccessioniPrimary (citable) accession number: Q504P2
Secondary accession number(s): Q8BN96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.