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Protein

Solute carrier family 22 member 15

Gene

Slc22a15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably transports organic cations. Appears not to be the agmatine transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 15
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:3607704. Slc22a15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence analysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence analysisAdd
BLAST
Transmembranei401 – 42020HelicalSequence analysisAdd
BLAST
Transmembranei433 – 45321HelicalSequence analysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Solute carrier family 22 member 15PRO_0000338620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ504N2.
PRIDEiQ504N2.

PTM databases

PhosphoSiteiQ504N2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033147.
ExpressionAtlasiQ504N2. baseline and differential.
GenevisibleiQ504N2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102541.

Structurei

3D structure databases

ProteinModelPortaliQ504N2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi526 – 5327Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI2. Eukaryota.
ENOG4110YHH. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000202179.
HOVERGENiHBG108435.
InParanoidiQ504N2.
KOiK08211.
OMAiTLMFIWF.
OrthoDBiEOG091G05DV.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q504N2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVEEAFQAV GEMGLYQMYL CFLLAVLLQL YVATEAILIA LIGATPAYHW
60 70 80 90 100
DMADLLPNQS HSNQTLGKGQ AFGDWLLTAN GSEIHKHVHF SNSFTSIASE
110 120 130 140 150
WFLIANRSYK VSAASSSFFS GVFVGVISFG QLSDRFGRRK VYLTGFALDI
160 170 180 190 200
LFAVANGFSP SYEFFAVTRF LVGMMNGGMS LVAFVLLNEC VGTAYWALAG
210 220 230 240 250
SIGGLFFAVG IAQYALLGYF IRSWRTLAVL VNLQGTLVFL LSLFIPESPR
260 270 280 290 300
WLYSQGRLSE AEEALYFIAK RNRKLKCTFS LTHPANRSYR ATGSFLDLFR
310 320 330 340 350
YRILLGHTLI LMFIWFVCSL VYYGLTLSAG DLGGSIYANL ALSGLIEIPS
360 370 380 390 400
YPLCIYLINQ RWFGRKRTLA AFLCLGGLAC LIVMFLPEKK DTGVFAVVNS
410 420 430 440 450
HSLSLLGKLT ISAAFNIVYI YTSELYPTVI RNVGLGACSM FSRVGGIIAP
460 470 480 490 500
FVPSLKEVQW SLPFIVFGAT GLTSGLLSLL LPETLNSPLL ETFSDLQMYS
510 520 530 540
YRRLGEEALS LQTLDPPQPL DKVSSESEEE EEFYDADEET QMIK
Length:544
Mass (Da):60,286
Last modified:April 3, 2013 - v3
Checksum:i8A58E1FB6B9EA80D
GO
Isoform 3 (identifier: Q504N2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-311: Missing.
     456-544: KEVQWSLPFI...DADEETQMIK → VEGSTVVSAL...SEQPFAGDIF

Show »
Length:184
Mass (Da):20,053
Checksum:i7D74DDAD9DF66990
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti370 – 3712AA → PP in BAC26569 (PubMed:16141072).Curated
Sequence conflicti457 – 4571E → D in AAI52348 (PubMed:15489334).Curated
Sequence conflicti519 – 5191P → S in AAI52348 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 311311Missing in isoform 3. 1 PublicationVSP_034061Add
BLAST
Alternative sequencei456 – 54489KEVQW…TQMIK → VEGSTVVSALHRVWSHRPDL RPPEPAIARDSEQPFAGDIF in isoform 3. 1 PublicationVSP_034064Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029695 mRNA. Translation: BAC26569.1.
AC165165 Genomic DNA. No translation available.
BC152347 mRNA. Translation: AAI52348.1.
CCDSiCCDS51022.1. [Q504N2-1]
RefSeqiNP_001034460.2. NM_001039371.2. [Q504N2-1]
UniGeneiMm.90204.

Genome annotation databases

EnsembliENSMUST00000106928; ENSMUSP00000102541; ENSMUSG00000033147. [Q504N2-1]
GeneIDi242126.
KEGGimmu:242126.
UCSCiuc008qrl.2. mouse. [Q504N2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029695 mRNA. Translation: BAC26569.1.
AC165165 Genomic DNA. No translation available.
BC152347 mRNA. Translation: AAI52348.1.
CCDSiCCDS51022.1. [Q504N2-1]
RefSeqiNP_001034460.2. NM_001039371.2. [Q504N2-1]
UniGeneiMm.90204.

3D structure databases

ProteinModelPortaliQ504N2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102541.

PTM databases

PhosphoSiteiQ504N2.

Proteomic databases

PaxDbiQ504N2.
PRIDEiQ504N2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106928; ENSMUSP00000102541; ENSMUSG00000033147. [Q504N2-1]
GeneIDi242126.
KEGGimmu:242126.
UCSCiuc008qrl.2. mouse. [Q504N2-1]

Organism-specific databases

CTDi55356.
MGIiMGI:3607704. Slc22a15.

Phylogenomic databases

eggNOGiENOG410IRI2. Eukaryota.
ENOG4110YHH. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000202179.
HOVERGENiHBG108435.
InParanoidiQ504N2.
KOiK08211.
OMAiTLMFIWF.
OrthoDBiEOG091G05DV.
TreeFamiTF315847.

Miscellaneous databases

PROiQ504N2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033147.
ExpressionAtlasiQ504N2. baseline and differential.
GenevisibleiQ504N2. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AF_MOUSE
AccessioniPrimary (citable) accession number: Q504N2
Secondary accession number(s): A7MCW2, F8WJ00, Q8CDR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 3, 2013
Last modified: September 7, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.