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Protein

Carboxypeptidase A2

Gene

Cpa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminal residues.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi177 – 1771Zinc; catalyticBy similarity
Metal bindingi180 – 1801Zinc; catalyticBy similarity
Binding sitei235 – 2351SubstrateBy similarity
Metal bindingi304 – 3041Zinc; catalyticBy similarity
Binding sitei356 – 3561SubstrateBy similarity
Active sitei378 – 3781Proton donor/acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase A2 (EC:3.4.17.15)
Gene namesi
Name:Cpa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:3617840. Cpa2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Propeptidei17 – 11296Activation peptidePRO_0000280809Add
BLAST
Chaini113 – 417305Carboxypeptidase A2PRO_0000280810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi246 ↔ 269By similarity
Disulfide bondi318 ↔ 352By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

MaxQBiQ504N0.
PaxDbiQ504N0.
PRIDEiQ504N0.

PTM databases

iPTMnetiQ504N0.
PhosphoSiteiQ504N0.

Expressioni

Gene expression databases

BgeeiQ504N0.
CleanExiMM_CPA2.
GenevisibleiQ504N0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093771.

Structurei

3D structure databases

ProteinModelPortaliQ504N0.
SMRiQ504N0. Positions 18-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni177 – 1804Substrate bindingBy similarity
Regioni252 – 2532Substrate bindingBy similarity
Regioni305 – 3062Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ504N0.
KOiK01298.
OMAiKAIMEHV.
OrthoDBiEOG7RZ5Q9.
PhylomeDBiQ504N0.
TreeFamiTF317197.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR000834. Peptidase_M14.
IPR003146. Prot_inh_M14A.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q504N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTPLLVAL FGYIYCQETF VGDQVLEVIP NDEEQIKTLL QLEAEEHLEL
60 70 80 90 100
DFWKSPSVPR QTVHVRVPFA SIQDVKVFLE SQGITYSIMI EDVQVLLDQE
110 120 130 140 150
REEMLFNQQR ERGTNFNFGA YHTLEEIYQE MDNLVAENPG LVSKVNIGSS
160 170 180 190 200
FENRPMNVLK FSTGGDKPAI WLDAGIHARE WVTQATALWT ANKIASDYGT
210 220 230 240 250
DPAITSLLNT LDVFLLPVTN PDGYVFSQTS NRMWRKTRSK RSGSFCVGVD
260 270 280 290 300
PNRNWDANFG GPGASSNPCS DSYHGPSPNS EVEVKSIVDF IKSHGKVKAF
310 320 330 340 350
ITLHSYSQLL MFPYGYKCAK PDDFNELDEV AQRAAQSLKR LHGTSYKVGP
360 370 380 390 400
ICSVIYQASG GSIDWAYDLG IKYSFAFELR DTGYYGFLLP AKQILPTAEE
410
TWLGLKTIME HVRDHPY
Length:417
Mass (Da):47,057
Last modified:June 7, 2005 - v1
Checksum:iA051FF523B9E1579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094929 mRNA. Translation: AAH94929.1.
CCDSiCCDS19974.1.
RefSeqiNP_001019869.1. NM_001024698.2.
UniGeneiMm.268855.

Genome annotation databases

EnsembliENSMUST00000096066; ENSMUSP00000093771; ENSMUSG00000071553.
GeneIDi232680.
KEGGimmu:232680.
UCSCiuc009bfn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094929 mRNA. Translation: AAH94929.1.
CCDSiCCDS19974.1.
RefSeqiNP_001019869.1. NM_001024698.2.
UniGeneiMm.268855.

3D structure databases

ProteinModelPortaliQ504N0.
SMRiQ504N0. Positions 18-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093771.

Protein family/group databases

MEROPSiM14.002.

PTM databases

iPTMnetiQ504N0.
PhosphoSiteiQ504N0.

Proteomic databases

MaxQBiQ504N0.
PaxDbiQ504N0.
PRIDEiQ504N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096066; ENSMUSP00000093771; ENSMUSG00000071553.
GeneIDi232680.
KEGGimmu:232680.
UCSCiuc009bfn.1. mouse.

Organism-specific databases

CTDi1358.
MGIiMGI:3617840. Cpa2.

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ504N0.
KOiK01298.
OMAiKAIMEHV.
OrthoDBiEOG7RZ5Q9.
PhylomeDBiQ504N0.
TreeFamiTF317197.

Miscellaneous databases

ChiTaRSiCpa2. mouse.
PROiQ504N0.
SOURCEiSearch...

Gene expression databases

BgeeiQ504N0.
CleanExiMM_CPA2.
GenevisibleiQ504N0. MM.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR000834. Peptidase_M14.
IPR003146. Prot_inh_M14A.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.

Entry informationi

Entry nameiCBPA2_MOUSE
AccessioniPrimary (citable) accession number: Q504N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 7, 2005
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.