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Protein

Ras-related protein Rab-26

Gene

Rab26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 829GTPBy similarity
Nucleotide bindingi123 – 1275GTPBy similarity
Nucleotide bindingi181 – 1844GTPBy similarity
Nucleotide bindingi211 – 2133GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-26
Gene namesi
Name:Rab26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2443284. Rab26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Ras-related protein Rab-26PRO_0000121219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi257 – 2571S-geranylgeranyl cysteineBy similarity
Lipidationi258 – 2581S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiQ504M8.
PaxDbiQ504M8.
PRIDEiQ504M8.

PTM databases

PhosphoSiteiQ504M8.

Expressioni

Tissue specificityi

Detected in zymogenic cells in the stomach.1 Publication

Gene expression databases

BgeeiQ504M8.
CleanExiMM_RAB26.
ExpressionAtlasiQ504M8. baseline and differential.
GenevisibleiQ504M8. MM.

Interactioni

Subunit structurei

Interacts with ADRA2B (By similarity). Interacts with RIMS1.By similarity1 Publication

Protein-protein interaction databases

BioGridi236652. 1 interaction.
IntActiQ504M8. 2 interactions.
STRINGi10090.ENSMUSP00000046089.

Structurei

3D structure databases

ProteinModelPortaliQ504M8.
SMRiQ504M8. Positions 62-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi97 – 1059Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0083. Eukaryota.
ENOG410Z9H6. LUCA.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ504M8.
KOiK07913.
PhylomeDBiQ504M8.
TreeFamiTF323428.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q504M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKKTPKSK GGSEPATSTL PAAAAATNGP RLAHPRTVRP GPEAPPNGPP
60 70 80 90 100
QSIRPSLGST GDFYDVAFKV MLVGDSGVGK TCLLVRFKDG AFLAGTFIST
110 120 130 140 150
VGIDFRNKVL DVDGMKVKLQ IWDTAGQERF RSVTHAYYRD AHALLLLYDI
160 170 180 190 200
TNKDSFDNIQ AWLTEIQEYA QQDVVLMLLG NKVDSTQDRV VKREDGEKLA
210 220 230 240 250
KEYGLPFMET SARTGLNVDL AFTAIAKELK QRSAKAPSEP RFRLHDYVKR
260
EGRGVSCCRL
Length:260
Mass (Da):28,619
Last modified:June 7, 2005 - v1
Checksum:i3657E725B1D004E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094931 mRNA. Translation: AAH94931.1.
CCDSiCCDS50016.1.
RefSeqiNP_796349.1. NM_177375.1.
UniGeneiMm.266033.

Genome annotation databases

EnsembliENSMUST00000035797; ENSMUSP00000046089; ENSMUSG00000079657.
GeneIDi328778.
KEGGimmu:328778.
UCSCiuc008awu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094931 mRNA. Translation: AAH94931.1.
CCDSiCCDS50016.1.
RefSeqiNP_796349.1. NM_177375.1.
UniGeneiMm.266033.

3D structure databases

ProteinModelPortaliQ504M8.
SMRiQ504M8. Positions 62-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236652. 1 interaction.
IntActiQ504M8. 2 interactions.
STRINGi10090.ENSMUSP00000046089.

PTM databases

PhosphoSiteiQ504M8.

Proteomic databases

MaxQBiQ504M8.
PaxDbiQ504M8.
PRIDEiQ504M8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035797; ENSMUSP00000046089; ENSMUSG00000079657.
GeneIDi328778.
KEGGimmu:328778.
UCSCiuc008awu.2. mouse.

Organism-specific databases

CTDi25837.
MGIiMGI:2443284. Rab26.

Phylogenomic databases

eggNOGiKOG0083. Eukaryota.
ENOG410Z9H6. LUCA.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ504M8.
KOiK07913.
PhylomeDBiQ504M8.
TreeFamiTF323428.

Miscellaneous databases

PROiQ504M8.
SOURCEiSearch...

Gene expression databases

BgeeiQ504M8.
CleanExiMM_RAB26.
ExpressionAtlasiQ504M8. baseline and differential.
GenevisibleiQ504M8. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  2. "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2."
    Fukuda M.
    J. Biol. Chem. 278:15373-15380(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIMS1.
  3. "RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation."
    Tian X., Jin R.U., Bredemeyer A.J., Oates E.J., Blazewska K.M., McKenna C.E., Mills J.C.
    Mol. Cell. Biol. 30:1269-1284(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRAB26_MOUSE
AccessioniPrimary (citable) accession number: Q504M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 7, 2005
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.