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Protein

Zinc finger protein 574

Gene

Znf574

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 38C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri76 – 98C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri126 – 148C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 414C2H2-type 8PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri467 – 490C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri496 – 518C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 631C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri637 – 660C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri668 – 690C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri740 – 762C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri768 – 790C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri796 – 818C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri824 – 846C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 574
Gene namesi
Name:Znf574
Synonyms:Zfp574
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311420. Zfp574.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748651 – 898Zinc finger protein 574Add BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei164PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei719PhosphoserineBy similarity1
Modified residuei726PhosphothreonineBy similarity1
Modified residuei834Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ504L7.
PRIDEiQ504L7.

Expressioni

Gene expression databases

GenevisibleiQ504L7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061367.

Structurei

3D structure databases

ProteinModelPortaliQ504L7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi658 – 735Ala-richAdd BLAST78

Sequence similaritiesi

Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 38C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri76 – 98C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri126 – 148C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 414C2H2-type 8PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri467 – 490C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri496 – 518C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 631C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri637 – 660C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri668 – 690C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri740 – 762C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri768 – 790C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri796 – 818C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri824 – 846C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00670000098063.
HOGENOMiHOG000065747.
HOVERGENiHBG103121.
InParanoidiQ504L7.
OMAiTHFPAPV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ504L7.
TreeFamiTF350791.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 20 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q504L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEESEETVL YIEHRYVCSE CNQLYGSLEE VLVHQNSHVP QQHFELVGVA
60 70 80 90 100
DPGVTVATEA TSGTGLYQTL IQESQYQCLE CGQLLLSPSQ LLEHQELHLK
110 120 130 140 150
MMAPQEAVPA EPPPKVPPLS SSTIHYECVD CKALFASQEM WLSHRQTHLR
160 170 180 190 200
ATPNKAPAPV VLGSPVVLGP PVGQARVAVE HSYRKAEEGG EGAAVPSVAA
210 220 230 240 250
ATEMVTEVEL LLYKCSECSQ LFQMPADFLE HQATHFPAPV PEAEEPATQQ
260 270 280 290 300
ETLVPSPTEA AVSQPDPLPA SDHSYELRNE LRNGEAMGRD RRGRKPRRSS
310 320 330 340 350
SGESGATQEL FCSACDQIFL SPHQLQQHLR SHREGVFKCP LCSRVFPSPS
360 370 380 390 400
SLDQHLGDHS SESHFLCVDC GLAFGTEALL LAHRRAHTPN PLHSCPCGKT
410 420 430 440 450
FVNLTKFLYH RRTHGAGGVP LPTTPVPPEE PAISFPEPAP AETGELEAPE
460 470 480 490 500
LPVSEESSAE PAAPGTYRCL LCSREFSKAL QLTRHQRFVH RLERRHKCSI
510 520 530 540 550
CGKMFKKKSH VRNHLRTHTG ERPFPCPDCS KPFNSPANLA RHRLTHTGER
560 570 580 590 600
PYRCGDCGKA FTQSSTLRQH RLVHAQHFPY RCQECGVRFH RPYRLLMHRY
610 620 630 640 650
HHTGEYPYKC RECPRSFLLR RLLEVHQLVV HAGRQPHRCP SCGAAFPSSL
660 670 680 690 700
RLREHRCAAA AAQAPRRFEC GTCGKKVGSA ARLQAHEAAH AAAGPGEVLA
710 720 730 740 750
KEPPAPRAAR ATRTPVAPSP TALGGTTSAA PAAPARRRGL ECSECKKLFS
760 770 780 790 800
TETSLQVHRR IHTGERPYPC PDCGKAFRQS THLKDHRRLH TGERPFACEV
810 820 830 840 850
CGKAFAISMR LAEHRRIHTG ERPYSCPDCG KSYRSFSNLW KHRKTHQQQH
860 870 880 890
QAAVRQQLAE AEAAVGLAVM ETAVEALPLV EAIEIYPLAE ADGVQISG
Length:898
Mass (Da):99,355
Last modified:June 7, 2005 - v1
Checksum:i2FA8BEC612F99693
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094953 mRNA. Translation: AAH94953.1.
RefSeqiNP_001019429.1. NM_001024258.1.
XP_008757152.1. XM_008758930.1.
XP_008757153.1. XM_008758931.2.
UniGeneiRn.15466.

Genome annotation databases

EnsembliENSRNOT00000079847; ENSRNOP00000070796; ENSRNOG00000055761.
GeneIDi308434.
KEGGirno:308434.
UCSCiRGD:1311420. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094953 mRNA. Translation: AAH94953.1.
RefSeqiNP_001019429.1. NM_001024258.1.
XP_008757152.1. XM_008758930.1.
XP_008757153.1. XM_008758931.2.
UniGeneiRn.15466.

3D structure databases

ProteinModelPortaliQ504L7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061367.

Proteomic databases

PaxDbiQ504L7.
PRIDEiQ504L7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000079847; ENSRNOP00000070796; ENSRNOG00000055761.
GeneIDi308434.
KEGGirno:308434.
UCSCiRGD:1311420. rat.

Organism-specific databases

CTDi232976.
RGDi1311420. Zfp574.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00670000098063.
HOGENOMiHOG000065747.
HOVERGENiHBG103121.
InParanoidiQ504L7.
OMAiTHFPAPV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ504L7.
TreeFamiTF350791.

Miscellaneous databases

PROiQ504L7.

Gene expression databases

GenevisibleiQ504L7. RN.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 20 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN574_RAT
AccessioniPrimary (citable) accession number: Q504L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 7, 2005
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.