ID   Q504I3_DANRE            Unreviewed;       251 AA.
AC   Q504I3; A0A0R4IVR5; F6P0R9;
DT   07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2005, sequence version 1.
DT   27-MAR-2024, entry version 146.
DE   SubName: Full=Hbl3 protein {ECO:0000313|EMBL:AAI65937.1};
DE   SubName: Full=Hexose-binding lectin 3 isoform X1 {ECO:0000313|RefSeq:XP_005171315.1};
DE   SubName: Full=Mannose binding lectin 2 precursor {ECO:0000313|RefSeq:NP_571645.2};
DE   SubName: Full=Mannose-binding lectin 2 {ECO:0000313|Ensembl:ENSDARP00000089300};
GN   Name=mbl2 {ECO:0000313|Ensembl:ENSDARP00000089300,
GN   ECO:0000313|RefSeq:NP_571645.2, ECO:0000313|ZFIN:ZDB-GENE-000427-2};
GN   Synonyms=etID42583.2 {ECO:0000313|RefSeq:NP_571645.2,
GN   ECO:0000313|RefSeq:XP_005171315.1}, fb68b07
GN   {ECO:0000313|RefSeq:NP_571645.2, ECO:0000313|RefSeq:XP_005171315.1},
GN   hbl3 {ECO:0000313|EMBL:AAH95009.1, ECO:0000313|RefSeq:NP_571645.2,
GN   ECO:0000313|RefSeq:XP_005171315.1}, mbl
GN   {ECO:0000313|RefSeq:NP_571645.2, ECO:0000313|RefSeq:XP_005171315.1},
GN   wu:fb68b07 {ECO:0000313|RefSeq:NP_571645.2,
GN   ECO:0000313|RefSeq:XP_005171315.1}, zgc:109836
GN   {ECO:0000313|RefSeq:XP_005171315.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI65937.1};
RN   [1] {ECO:0000313|RefSeq:NP_571645.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11003389; DOI=10.1007/s002510000232;
RA   Vitved L., Holmskov U., Koch C., Teisner B., Hansen S., Salomonsen J.,
RA   Skjodt K.;
RT   "The homologue of mannose-binding lectin in the carp family Cyprinidae is
RT   expressed at high level in spleen, and the deduced primary structure
RT   predicts affinity for galactose.";
RL   Immunogenetics 51:955-964(2000).
RN   [2] {ECO:0000313|RefSeq:NP_571645.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11991814;
RA   Zhao H., Wakamiya N., Suzuki Y., Hamonko M.T., Stahl G.L.;
RT   "Identification of human mannose binding lectin (MBL) recognition sites for
RT   novel inhibitory antibodies.";
RL   Hybrid. Hybridomics 21:25-36(2002).
RN   [3] {ECO:0000313|RefSeq:NP_571645.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16109975;
RA   Woods I.G., Wilson C., Friedlander B., Chang P., Reyes D.K., Nix R.,
RA   Kelly P.D., Chu F., Postlethwait J.H., Talbot W.S.;
RT   "The zebrafish gene map defines ancestral vertebrate chromosomes.";
RL   Genome Res. 15:1307-1314(2005).
RN   [4] {ECO:0000313|RefSeq:NP_571645.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17015733;
RA   Nakao M., Kajiya T., Sato Y., Somamoto T., Kato-Unoki Y., Matsushita M.,
RA   Nakata M., Fujita T., Yano T.;
RT   "Lectin pathway of bony fish complement: identification of two homologs of
RT   the mannose-binding lectin associated with MASP2 in the common carp
RT   (Cyprinus carpio).";
RL   J. Immunol. 177:5471-5479(2006).
RN   [5] {ECO:0000313|RefSeq:NP_571645.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17943278;
RA   Jackson A.N., McLure C.A., Dawkins R.L., Keating P.J.;
RT   "Mannose binding lectin (MBL) copy number polymorphism in Zebrafish (D.
RT   rerio) and identification of haplotypes resistant to L. anguillarum.";
RL   Immunogenetics 59:861-872(2007).
RN   [6] {ECO:0000313|RefSeq:NP_571645.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18657447;
RA   Wang Z., Zhang S., Wang G.;
RT   "Response of complement expression to challenge with lipopolysaccharide in
RT   embryos/larvae of zebrafish Danio rerio: acquisition of immunocompetent
RT   complement.";
RL   Fish Shellfish Immunol. 25:264-270(2008).
RN   [7] {ECO:0000313|EMBL:AAI65937.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:AAH95009.1}, and PCR rescue
RC   {ECO:0000313|EMBL:AAI65937.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|RefSeq:NP_571645.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20565988;
RA   Wang Z., Du J., Lam S.H., Mathavan S., Matsudaira P., Gong Z.;
RT   "Morphological and molecular evidence for functional organization along the
RT   rostrocaudal axis of the adult zebrafish intestine.";
RL   BMC Genomics 11:392-392(2010).
RN   [9] {ECO:0000313|RefSeq:NP_571645.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21524427;
RA   Zhang H., Peatman E., Liu H., Niu D., Feng T., Kucuktas H., Waldbieser G.,
RA   Chen L., Liu Z.;
RT   "Characterization of a mannose-binding lectin from channel catfish
RT   (Ictalurus punctatus).";
RL   Res. Vet. Sci. 92:408-413(2012).
RN   [10] {ECO:0000313|Ensembl:ENSDARP00000089300}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000089300};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [11] {ECO:0000313|Ensembl:ENSDARP00000089300, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000089300};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [12] {ECO:0000313|Ensembl:ENSDARP00000157393}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139226};
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
RN   [13] {ECO:0000313|RefSeq:NP_571645.2, ECO:0000313|RefSeq:XP_005171315.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005171315.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL954692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC095009; AAH95009.1; -; mRNA.
DR   EMBL; BC165937; AAI65937.1; -; mRNA.
DR   RefSeq; NP_571645.2; NM_131570.2.
DR   RefSeq; XP_005171315.1; XM_005171258.4.
DR   STRING; 7955.ENSDARP00000089300; -.
DR   PaxDb; 7955-ENSDARP00000089300; -.
DR   Ensembl; ENSDART00000098529.5; ENSDARP00000089300.3; ENSDARG00000068220.6.
DR   Ensembl; ENSDART00000168939.2; ENSDARP00000139226.1; ENSDARG00000068220.6.
DR   Ensembl; ENSDART00000183277.1; ENSDARP00000157393.1; ENSDARG00000068220.6.
DR   GeneID; 100008009; -.
DR   KEGG; dre:100008009; -.
DR   AGR; ZFIN:ZDB-GENE-000427-2; -.
DR   CTD; 4153; -.
DR   ZFIN; ZDB-GENE-000427-2; mbl2.
DR   eggNOG; KOG4297; Eukaryota.
DR   HOGENOM; CLU_049894_3_0_1; -.
DR   OMA; KWDQNAC; -.
DR   OrthoDB; 4232229at2759; -.
DR   TreeFam; TF330481; -.
DR   Proteomes; UP000000437; Alternate scaffold 2.
DR   Proteomes; UP000000437; Chromosome 2.
DR   Bgee; ENSDARG00000068220; Expressed in intestine and 14 other cell types or tissues.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   CDD; cd03591; CLECT_collectin_like; 1.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR018378; C-type_lectin_CS.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR033990; Collectin_CTLD.
DR   InterPro; IPR016187; CTDL_fold.
DR   PANTHER; PTHR22801:SF53; 27 KDA PRIMARY MESENCHYME-SPECIFIC SPICULE PROTEIN; 1.
DR   PANTHER; PTHR22801; LITHOSTATHINE; 1.
DR   Pfam; PF01391; Collagen; 1.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Collagen {ECO:0000256|ARBA:ARBA00023119};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..251
FT                   /evidence="ECO:0000256|SAM:SignalP,
FT                   ECO:0000313|RefSeq:NP_571645.2"
FT                   /id="PRO_5035035818"
FT   DOMAIN          137..247
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000259|PROSITE:PS50041"
FT   REGION          36..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   251 AA;  26815 MW;  E30AB525A917B82E CRC64;
     MALLKLFLGA LLLLQLVLQL LAGAADPQSL NCPAYAGVPG TPGHNGLPGR DGRDGRDGAT
     GPKGEKGEPG VNVQGPPGKA GPPGPAGAKG ERGPSGLPGQ DCMSDSLKSE LQKLSDKIAL
     IEKVVNFKTF KKVGQKYYVT DDVEETFDKG MQYCSSNGGA LVLPRTLEEN ALLKVFVSSA
     FKRLFIRITD REKEGEFVDT DRKKLTFTNW GPNQPDNYKG AQDCGAIADS GLWDDVSCDS
     LYPIICEIEI K
//