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Protein
Submitted name:

Hbl3 protein

Gene

hbl3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-DRE-166662. Lectin pathway of complement activation.
R-DRE-166663. Initial triggering of complement.

Names & Taxonomyi

Protein namesi
Submitted name:
Hbl3 proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:hbl3Imported
Synonyms:mblImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-000427-2. hbl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 251229Sequence analysisPRO_5005933096Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000089300.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 247111C-type lectinInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili104 – 12421Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains C-type lectin domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, CollagenSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IS38. Eukaryota.
ENOG410YQHR. LUCA.
GeneTreeiENSGT00700000104102.
HOVERGENiHBG108270.
OMAiETVTCED.
OrthoDBiEOG7DFXD9.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q504I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLKLFLGA LLLLQLVLQL LAGAADPQSL NCPAYAGVPG TPGHNGLPGR
60 70 80 90 100
DGRDGRDGAT GPKGEKGEPG VNVQGPPGKA GPPGPAGAKG ERGPSGLPGQ
110 120 130 140 150
DCMSDSLKSE LQKLSDKIAL IEKVVNFKTF KKVGQKYYVT DDVEETFDKG
160 170 180 190 200
MQYCSSNGGA LVLPRTLEEN ALLKVFVSSA FKRLFIRITD REKEGEFVDT
210 220 230 240 250
DRKKLTFTNW GPNQPDNYKG AQDCGAIADS GLWDDVSCDS LYPIICEIEI

K
Length:251
Mass (Da):26,815
Last modified:June 7, 2005 - v1
Checksum:iE30AB525A917B82E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954692 Genomic DNA. No translation available.
BC095009 mRNA. Translation: AAH95009.1.
BC165937 mRNA. Translation: AAI65937.1.
RefSeqiNP_571645.2. NM_131570.2.
XP_005171315.1. XM_005171258.2.
UniGeneiDr.77668.

Genome annotation databases

EnsembliENSDART00000098529; ENSDARP00000089300; ENSDARG00000068220.
ENSDART00000168939; ENSDARP00000139226; ENSDARG00000068220.
GeneIDi100008009.
KEGGidre:100008009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954692 Genomic DNA. No translation available.
BC095009 mRNA. Translation: AAH95009.1.
BC165937 mRNA. Translation: AAI65937.1.
RefSeqiNP_571645.2. NM_131570.2.
XP_005171315.1. XM_005171258.2.
UniGeneiDr.77668.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000089300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000098529; ENSDARP00000089300; ENSDARG00000068220.
ENSDART00000168939; ENSDARP00000139226; ENSDARG00000068220.
GeneIDi100008009.
KEGGidre:100008009.

Organism-specific databases

CTDi100008009.
ZFINiZDB-GENE-000427-2. hbl3.

Phylogenomic databases

eggNOGiENOG410IS38. Eukaryota.
ENOG410YQHR. LUCA.
GeneTreeiENSGT00700000104102.
HOVERGENiHBG108270.
OMAiETVTCED.
OrthoDBiEOG7DFXD9.
TreeFamiTF330481.

Enzyme and pathway databases

ReactomeiR-DRE-166662. Lectin pathway of complement activation.
R-DRE-166663. Initial triggering of complement.

Miscellaneous databases

NextBioi20787713.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LiverImported.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  5. Ensembl
    Submitted (NOV-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ504I3_DANRE
AccessioniPrimary (citable) accession number: Q504I3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: January 20, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.