Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Type A flavoprotein FprA

Gene

fprA

Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions as an electron acceptor for a hydrogenase; however there is an uncharacterized intermediate between the hydrogenase and flavoprotein A.

Cofactori

Protein has several cofactor binding sites:
  • FMNNote: Binds 1 FMN per subunit.
  • Fe cationNote: Binds 2 iron ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Iron 1By similarity1
Metal bindingi85Iron 1By similarity1
Metal bindingi87Iron 2By similarity1
Metal bindingi151Iron 1By similarity1
Metal bindingi170Iron 1By similarity1
Metal bindingi170Iron 2By similarity1
Metal bindingi233Iron 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Flavoprotein, FMN, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18960.
BRENDAi1.5.3.22. 7427.

Names & Taxonomyi

Protein namesi
Recommended name:
Type A flavoprotein FprA (EC:1.-.-.-)
Alternative name(s):
FMN protein FprA
Flavoprotein A
Gene namesi
Name:fprA
Synonyms:fpaA, fprA3
Ordered Locus Names:MTBMA_c17400
OrganismiMethanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000000345 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002168081 – 404Type A flavoprotein FprAAdd BLAST404

Expressioni

Inductioni

By iron limitation.

Interactioni

Subunit structurei

Homodimer or homotetramer.

Protein-protein interaction databases

STRINGi79929.MTBMA_c17400.

Structurei

Secondary structure

1404
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi12 – 14Combined sources3
Beta strandi17 – 19Combined sources3
Beta strandi33 – 35Combined sources3
Beta strandi38 – 41Combined sources4
Beta strandi46 – 49Combined sources4
Helixi57 – 71Combined sources15
Beta strandi78 – 80Combined sources3
Helixi86 – 89Combined sources4
Helixi92 – 98Combined sources7
Beta strandi104 – 106Combined sources3
Helixi108 – 117Combined sources10
Helixi119 – 123Combined sources5
Beta strandi126 – 128Combined sources3
Beta strandi134 – 136Combined sources3
Beta strandi141 – 146Combined sources6
Beta strandi150 – 152Combined sources3
Beta strandi156 – 161Combined sources6
Turni162 – 164Combined sources3
Beta strandi165 – 167Combined sources3
Turni169 – 172Combined sources4
Helixi183 – 185Combined sources3
Helixi188 – 202Combined sources15
Helixi204 – 206Combined sources3
Helixi207 – 219Combined sources13
Helixi223 – 225Combined sources3
Beta strandi227 – 230Combined sources4
Beta strandi232 – 234Combined sources3
Beta strandi236 – 239Combined sources4
Helixi240 – 251Combined sources12
Beta strandi257 – 263Combined sources7
Beta strandi266 – 268Combined sources3
Helixi269 – 282Combined sources14
Turni283 – 285Combined sources3
Beta strandi287 – 292Combined sources6
Turni293 – 295Combined sources3
Helixi298 – 306Combined sources9
Beta strandi309 – 314Combined sources6
Helixi325 – 336Combined sources12
Helixi338 – 340Combined sources3
Beta strandi344 – 355Combined sources12
Helixi358 – 368Combined sources11
Beta strandi371 – 382Combined sources12
Helixi385 – 402Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OHHX-ray1.70A/B/D/E1-404[»]
2OHIX-ray2.30A/B/D/E/G/H/I/J1-404[»]
2OHJX-ray2.26A/B/D/E1-404[»]
ProteinModelPortaliQ50497.
SMRiQ50497.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ50497.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 399Flavodoxin-likePROSITE-ProRule annotationAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 206Zinc metallo-hydrolaseAdd BLAST177

Sequence similaritiesi

In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.Curated
Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG00509. Archaea.
COG0426. LUCA.
HOGENOMiHOG000224528.
KOiK19817.
OMAiINCELAD.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
3.60.15.10. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR001226. Flavodoxin_CS.
IPR029039. Flavoprotein-like_dom.
IPR001279. Metallo-B-lactamas.
IPR016440. Rubredoxin-O_OxRdtase.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
PIRSFiPIRSF005243. ROO. 1 hit.
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56281. SSF56281. 1 hit.
PROSITEiPS00201. FLAVODOXIN. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAAKRISD GVYWTGVLDW DLRNYHGYTL QGTTYNAYLV CGDEGVALID
60 70 80 90 100
NSYPGTFDEL MARVEDALQQ VGMERVDYII QNHVEKDHSG VLVELHRRFP
110 120 130 140 150
EAPIYCTEVA VKGLLKHYPS LREAEFMTVK TGDVLDLGGK TLTFLETPLL
160 170 180 190 200
HWPDSMFTLL DEDGILFSND AFGQHLCCPQ RLDREIPEYI LMDAARKFYA
210 220 230 240 250
NLITPLSKLV LKKFDEVKEL GLLERIQMIA PSHGQIWTDP MKIIEAYTGW
260 270 280 290 300
ATGMVDERVT VIYDTMHGST RKMAHAIAEG AMSEGVDVRV YCLHEDDRSE
310 320 330 340 350
IVKDILESGA IALGAPTIYD EPYPSVGDLL MYLRGLKFNR TLTRKALVFG
360 370 380 390 400
SMGGNGGATG TMKELLAEAG FDVACEEEVY YVPTGDELDA CFEAGRKLAA

EIRR
Length:404
Mass (Da):45,205
Last modified:November 1, 1996 - v1
Checksum:i155AF7D9FE9D75FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17835 Genomic DNA. Translation: AAB88013.1.
CP001710 Genomic DNA. Translation: ADL59308.1.
RefSeqiWP_013296518.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL59308; ADL59308; MTBMA_c17400.
GeneIDi9705451.
KEGGimmg:MTBMA_c17400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17835 Genomic DNA. Translation: AAB88013.1.
CP001710 Genomic DNA. Translation: ADL59308.1.
RefSeqiWP_013296518.1. NC_014408.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OHHX-ray1.70A/B/D/E1-404[»]
2OHIX-ray2.30A/B/D/E/G/H/I/J1-404[»]
2OHJX-ray2.26A/B/D/E1-404[»]
ProteinModelPortaliQ50497.
SMRiQ50497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi79929.MTBMA_c17400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL59308; ADL59308; MTBMA_c17400.
GeneIDi9705451.
KEGGimmg:MTBMA_c17400.

Phylogenomic databases

eggNOGiarCOG00509. Archaea.
COG0426. LUCA.
HOGENOMiHOG000224528.
KOiK19817.
OMAiINCELAD.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18960.
BRENDAi1.5.3.22. 7427.

Miscellaneous databases

EvolutionaryTraceiQ50497.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
3.60.15.10. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR001226. Flavodoxin_CS.
IPR029039. Flavoprotein-like_dom.
IPR001279. Metallo-B-lactamas.
IPR016440. Rubredoxin-O_OxRdtase.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
PIRSFiPIRSF005243. ROO. 1 hit.
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56281. SSF56281. 1 hit.
PROSITEiPS00201. FLAVODOXIN. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPRA_METTM
AccessioniPrimary (citable) accession number: Q50497
Secondary accession number(s): D9PYL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.