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Protein

Type A flavoprotein FprA

Gene

fprA

Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions as an electron acceptor for a hydrogenase; however there is an uncharacterized intermediate between the hydrogenase and flavoprotein A.

Cofactori

Protein has several cofactor binding sites:
  • FMNNote: Binds 1 FMN per subunit.
  • Fe cationNote: Binds 2 iron ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Iron 1By similarity
Metal bindingi85 – 851Iron 1By similarity
Metal bindingi87 – 871Iron 2By similarity
Metal bindingi151 – 1511Iron 1By similarity
Metal bindingi170 – 1701Iron 1By similarity
Metal bindingi170 – 1701Iron 2By similarity
Metal bindingi233 – 2331Iron 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Flavoprotein, FMN, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMMAR79929:GH5J-1746-MONOMER.
BRENDAi1.5.3.22. 7427.

Names & Taxonomyi

Protein namesi
Recommended name:
Type A flavoprotein FprA (EC:1.-.-.-)
Alternative name(s):
FMN protein FprA
Flavoprotein A
Gene namesi
Name:fprA
Synonyms:fpaA, fprA3
Ordered Locus Names:MTBMA_c17400
OrganismiMethanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000000345 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Type A flavoprotein FprAPRO_0000216808Add
BLAST

Expressioni

Inductioni

By iron limitation.

Interactioni

Subunit structurei

Homodimer or homotetramer.

Protein-protein interaction databases

STRINGi79929.MTBMA_c17400.

Structurei

Secondary structure

1
404
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94Combined sources
Beta strandi12 – 143Combined sources
Beta strandi17 – 193Combined sources
Beta strandi33 – 353Combined sources
Beta strandi38 – 414Combined sources
Beta strandi46 – 494Combined sources
Helixi57 – 7115Combined sources
Beta strandi78 – 803Combined sources
Helixi86 – 894Combined sources
Helixi92 – 987Combined sources
Beta strandi104 – 1063Combined sources
Helixi108 – 11710Combined sources
Helixi119 – 1235Combined sources
Beta strandi126 – 1283Combined sources
Beta strandi134 – 1363Combined sources
Beta strandi141 – 1466Combined sources
Beta strandi150 – 1523Combined sources
Beta strandi156 – 1616Combined sources
Turni162 – 1643Combined sources
Beta strandi165 – 1673Combined sources
Turni169 – 1724Combined sources
Helixi183 – 1853Combined sources
Helixi188 – 20215Combined sources
Helixi204 – 2063Combined sources
Helixi207 – 21913Combined sources
Helixi223 – 2253Combined sources
Beta strandi227 – 2304Combined sources
Beta strandi232 – 2343Combined sources
Beta strandi236 – 2394Combined sources
Helixi240 – 25112Combined sources
Beta strandi257 – 2637Combined sources
Beta strandi266 – 2683Combined sources
Helixi269 – 28214Combined sources
Turni283 – 2853Combined sources
Beta strandi287 – 2926Combined sources
Turni293 – 2953Combined sources
Helixi298 – 3069Combined sources
Beta strandi309 – 3146Combined sources
Helixi325 – 33612Combined sources
Helixi338 – 3403Combined sources
Beta strandi344 – 35512Combined sources
Helixi358 – 36811Combined sources
Beta strandi371 – 38212Combined sources
Helixi385 – 40218Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OHHX-ray1.70A/B/D/E1-404[»]
2OHIX-ray2.30A/B/D/E/G/H/I/J1-404[»]
2OHJX-ray2.26A/B/D/E1-404[»]
ProteinModelPortaliQ50497.
SMRiQ50497. Positions 1-403.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ50497.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 399141Flavodoxin-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 206177Zinc metallo-hydrolaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.Curated
Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG00509. Archaea.
COG0426. LUCA.
HOGENOMiHOG000224528.
KOiK19817.
OMAiINCELAD.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
3.60.15.10. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR001226. Flavodoxin_CS.
IPR029039. Flavoprotein-like_dom.
IPR001279. Metallo-B-lactamas.
IPR016440. Rubredoxin-O_OxRdtase.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
PIRSFiPIRSF005243. ROO. 1 hit.
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56281. SSF56281. 1 hit.
PROSITEiPS00201. FLAVODOXIN. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAAKRISD GVYWTGVLDW DLRNYHGYTL QGTTYNAYLV CGDEGVALID
60 70 80 90 100
NSYPGTFDEL MARVEDALQQ VGMERVDYII QNHVEKDHSG VLVELHRRFP
110 120 130 140 150
EAPIYCTEVA VKGLLKHYPS LREAEFMTVK TGDVLDLGGK TLTFLETPLL
160 170 180 190 200
HWPDSMFTLL DEDGILFSND AFGQHLCCPQ RLDREIPEYI LMDAARKFYA
210 220 230 240 250
NLITPLSKLV LKKFDEVKEL GLLERIQMIA PSHGQIWTDP MKIIEAYTGW
260 270 280 290 300
ATGMVDERVT VIYDTMHGST RKMAHAIAEG AMSEGVDVRV YCLHEDDRSE
310 320 330 340 350
IVKDILESGA IALGAPTIYD EPYPSVGDLL MYLRGLKFNR TLTRKALVFG
360 370 380 390 400
SMGGNGGATG TMKELLAEAG FDVACEEEVY YVPTGDELDA CFEAGRKLAA

EIRR
Length:404
Mass (Da):45,205
Last modified:November 1, 1996 - v1
Checksum:i155AF7D9FE9D75FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17835 Genomic DNA. Translation: AAB88013.1.
CP001710 Genomic DNA. Translation: ADL59308.1.
RefSeqiWP_013296518.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL59308; ADL59308; MTBMA_c17400.
GeneIDi9705451.
KEGGimmg:MTBMA_c17400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17835 Genomic DNA. Translation: AAB88013.1.
CP001710 Genomic DNA. Translation: ADL59308.1.
RefSeqiWP_013296518.1. NC_014408.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OHHX-ray1.70A/B/D/E1-404[»]
2OHIX-ray2.30A/B/D/E/G/H/I/J1-404[»]
2OHJX-ray2.26A/B/D/E1-404[»]
ProteinModelPortaliQ50497.
SMRiQ50497. Positions 1-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi79929.MTBMA_c17400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL59308; ADL59308; MTBMA_c17400.
GeneIDi9705451.
KEGGimmg:MTBMA_c17400.

Phylogenomic databases

eggNOGiarCOG00509. Archaea.
COG0426. LUCA.
HOGENOMiHOG000224528.
KOiK19817.
OMAiINCELAD.

Enzyme and pathway databases

BioCyciMMAR79929:GH5J-1746-MONOMER.
BRENDAi1.5.3.22. 7427.

Miscellaneous databases

EvolutionaryTraceiQ50497.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
3.60.15.10. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR001226. Flavodoxin_CS.
IPR029039. Flavoprotein-like_dom.
IPR001279. Metallo-B-lactamas.
IPR016440. Rubredoxin-O_OxRdtase.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
PIRSFiPIRSF005243. ROO. 1 hit.
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56281. SSF56281. 1 hit.
PROSITEiPS00201. FLAVODOXIN. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPRA_METTM
AccessioniPrimary (citable) accession number: Q50497
Secondary accession number(s): D9PYL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.