Q50438 (PQQC_METFL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroloquinoline-quinone synthase
EC=1.3.3.11

Alternative name(s):
Coenzyme PQQ synthesis protein C
Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:

pqqC

Organism

Methylobacillus flagellatum

Taxonomic identifier

405 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus

Protein attributes

Sequence length	52 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP MF_00654
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›52	›52	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_0000219981
Experimental info
	Non-terminal residue	52	1

Sequences

	Sequence		Length	Mass (Da)
	Q50438 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3EE6EE2742DBBAE1	FASTA	52	6,365
	10 20 30 40 50 MNAPLTDNIP WTREEFEQKL RDKGRGYHIY HPFHVMMYEG KLTREQLQCW VA

References

[1]

"Identification and characterization of the pqqDGC gene cluster involved in pyrroloquinoline quinone production in an obligate methylotroph Methylobacillus flagellatum." Gomelsky M., Biville F., Gasser F., Tsygankov Y.D. FEMS Microbiol. Lett. 141:169-176(1996) [PubMed: 8768519] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L78064 Genomic DNA. Translation: AAB42381.1.
3D structure databases
ProteinModelPortal	Q50438.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00654. PQQ_syn_PqqC. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR004305. TENA/THI4/PQQ_synthPqqC_dom. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
SUPFAM	SSF48613. Heme_oxygenase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_METFL

Accession

Primary (citable) accession number: Q50438

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	November 1, 1996
Last modified:	September 21, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program