Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q50438 (PQQC_METFL)

Last modified January 20, 2009. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C
Gene names
Name: pqqC
OrganismMethylobacillus flagellatum
Taxonomic identifier405 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylobacillus

Protein attributes

Sequence length52 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity.

Catalytic activity

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654

Pathway

Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654

Sequence similarities

Belongs to the pqqC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›52›52Pyrroloquinoline-quinone synthase HAMAP MF_00654
PRO_0000219981

Experimental info

Non-terminal residue521

Sequences

Sequence LengthMass (Da)Tools
Q50438-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3EE6EE2742DBBAE1

FASTA526,365
        10         20         30         40         50 
MNAPLTDNIP WTREEFEQKL RDKGRGYHIY HPFHVMMYEG KLTREQLQCW VA 

« Hide

References

[1]"Identification and characterization of the pqqDGC gene cluster involved in pyrroloquinoline quinone production in an obligate methylotroph Methylobacillus flagellatum."
Gomelsky M., Biville F., Gasser F., Tsygankov Y.D.
FEMS Microbiol. Lett. 141:169-176(1996) [PubMed: 8768519] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

L78064 Genomic DNA. Translation: AAB42381.1.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA1.3.3.11. 165048.

Family and domain databases

HAMAPMF_00654.
[Tree]
InterProIPR016084. Haem_Oase-like_multi-hlx.
IPR004305. TENA/THI4/PQQ_synth_PqqC.
[Graphical view]
Gene3DG3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
PfamPF03070. TENA_THI-4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePQQC_METFL
AccessionPrimary (citable) accession number: Q50438
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: November 1, 1996
Last modified: January 20, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents