Q50438 (PQQC_METFL) Reviewed, UniProtKB/Swiss-Prot
Last modified
September 21, 2011.
Version 46.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Pyrroloquinoline-quinone synthase EC=1.3.3.11 Alternative name(s): Coenzyme PQQ synthesis protein C Pyrroloquinoline quinone biosynthesis protein C | ||
| Gene names |
| ||
| Organism | Methylobacillus flagellatum | ||
| Taxonomic identifier | 405 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Methylophilales › Methylophilaceae › Methylobacillus |
Protein attributes
| Sequence length | 52 AA. |
| Sequence status | Fragment. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP MF_00654 |
| Catalytic activity | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654 |
| Pathway | Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654 |
| Sequence similarities | Belongs to the pqqC family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | PQQ biosynthesis |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – ›52 | ›52 | Pyrroloquinoline-quinone synthase HAMAP MF_00654 | PRO_0000219981 | ||||
Experimental info | ||||||||
| Non-terminal residue | 52 | 1 | ||||||
Sequences
References
| [1] | "Identification and characterization of the pqqDGC gene cluster involved in pyrroloquinoline quinone production in an obligate methylotroph Methylobacillus flagellatum." Gomelsky M., Biville F., Gasser F., Tsygankov Y.D. FEMS Microbiol. Lett. 141:169-176(1996) [PubMed: 8768519] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L78064 Genomic DNA. Translation: AAB42381.1. |
3D structure databases | |
| ProteinModelPortal | Q50438. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| HAMAP | MF_00654. PQQ_syn_PqqC. [Tree] |
| InterPro | IPR016084. Haem_Oase-like_multi-hlx. IPR004305. TENA/THI4/PQQ_synthPqqC_dom. [Graphical view] |
| Gene3D | G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit. |
| Pfam | PF03070. TENA_THI-4. 1 hit. [Graphical view] |
| SUPFAM | SSF48613. Heme_oxygenase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PQQC_METFL | ||||||||
| Accession | Primary (citable) accession number: Q50438 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with