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Q503Z4

- Q503Z4_DANRE

UniProt

Q503Z4 - Q503Z4_DANRE

Protein
Submitted name:

Neu4

Gene

neu4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. exo-alpha-sialidase activity Source: ZFIN

    GO - Biological processi

    1. ganglioside metabolic process Source: ZFIN

    Enzyme and pathway databases

    ReactomeiREACT_221391. Glycosphingolipid metabolism.
    REACT_221720. Sialic acid metabolism.

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Neu4Imported
    Submitted name:
    Neu4 proteinImported
    Submitted name:
    Sialidase 4Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:neu4Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 15

    Organism-specific databases

    ZFINiZDB-GENE-050522-125. neu4.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ZFIN

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000074848.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG84455.
    GeneTreeiENSGT00390000011171.
    HOGENOMiHOG000233778.
    HOVERGENiHBG052608.
    InParanoidiQ503Z4.
    KOiK12357.
    OMAiMNPCPVL.
    OrthoDBiEOG7MSMNP.
    TreeFamiTF331063.

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR026946. Sialidase-4.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF8. PTHR10628:SF8. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q503Z4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSQYYPARS ILFQKEPSGV TYRVPALIYI PRSSCFLAFC EERLTPADAQ    50
    AHLLVMRKGT FYKNYVEWKD MEVLSTARLE GYRSMNPCPV YDEFTDTIFL 100
    FFIAVLGHTS ESYQLITGKN VTRLCYVSSC DQGDTWSNAT DLTRTLIGDT 150
    IKEWATFAVG PGHGTQLKSG RLIIPAYAYH IDCRNCFGKT CKTSPHSFCF 200
    YSDTHGNVWH FGQALSEPNS VECQMVSVDE EDGVNLLYCN ARSISGYRVQ 250
    AVSFDHGTFF QDGQLVHKLL EPRNGCHGSV IGFPAPIFQL ERFKSIYNSL 300
    ELSAAPRSPK NFLPPTWVVY SHPTCPNSRR DLGVYLSLLP RDPDSWSGPW 350
    IIYDGPSAYS DLAYVDLMSS DAAGVTVFAC LFESGTKTAY DEISFCIFTL 400
    YELIDHLPQD QEKTTLLKRK RIWERCFIC 429
    Length:429
    Mass (Da):48,517
    Last modified:June 7, 2005 - v1
    Checksum:iB32252C2305F2317
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU694447 Genomic DNA. No translation available.
    BC095117 mRNA. Translation: AAH95117.1.
    BC165570 mRNA. Translation: AAI65570.1.
    EF116275 mRNA. Translation: ABO45315.1.
    RefSeqiNP_001018384.1. NM_001020548.2.
    XP_005169770.1. XM_005169713.1.
    UniGeneiDr.89238.

    Genome annotation databases

    EnsembliENSDART00000080398; ENSDARP00000074848; ENSDARG00000057677.
    GeneIDi553569.
    KEGGidre:553569.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU694447 Genomic DNA. No translation available.
    BC095117 mRNA. Translation: AAH95117.1 .
    BC165570 mRNA. Translation: AAI65570.1 .
    EF116275 mRNA. Translation: ABO45315.1 .
    RefSeqi NP_001018384.1. NM_001020548.2.
    XP_005169770.1. XM_005169713.1.
    UniGenei Dr.89238.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000074848.

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000080398 ; ENSDARP00000074848 ; ENSDARG00000057677 .
    GeneIDi 553569.
    KEGGi dre:553569.

    Organism-specific databases

    CTDi 129807.
    ZFINi ZDB-GENE-050522-125. neu4.

    Phylogenomic databases

    eggNOGi NOG84455.
    GeneTreei ENSGT00390000011171.
    HOGENOMi HOG000233778.
    HOVERGENi HBG052608.
    InParanoidi Q503Z4.
    KOi K12357.
    OMAi MNPCPVL.
    OrthoDBi EOG7MSMNP.
    TreeFami TF331063.

    Enzyme and pathway databases

    Reactomei REACT_221391. Glycosphingolipid metabolism.
    REACT_221720. Sialic acid metabolism.

    Miscellaneous databases

    NextBioi 20880308.
    PROi Q503Z4.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR026946. Sialidase-4.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF8. PTHR10628:SF8. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EyeImported.
    2. "Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio)."
      Manzoni M., Colombi P., Papini N., Rubaga L., Tiso N., Preti A., Venerando B., Tettamanti G., Bresciani R., Argenton F., Borsani G., Monti E.
      Biochem. J. 408:395-406(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescueImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    5. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiQ503Z4_DANRE
    AccessioniPrimary (citable) accession number: Q503Z4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3