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Protein
Submitted name:

Neu4

Gene

neu4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: ZFIN

GO - Biological processi

  1. ganglioside metabolic process Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_324112. Glycosphingolipid metabolism.
REACT_348107. Sialic acid metabolism.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Neu4Imported
Submitted name:
Neu4 proteinImported
Submitted name:
Sialidase 4Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:neu4Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 15

Organism-specific databases

ZFINiZDB-GENE-050522-125. neu4.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: ZFIN
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ503Z4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000074848.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG84455.
GeneTreeiENSGT00390000011171.
HOGENOMiHOG000233778.
HOVERGENiHBG052608.
InParanoidiQ503Z4.
KOiK12357.
OMAiHIDCKEC.
OrthoDBiEOG7MSMNP.
PhylomeDBiQ503Z4.
TreeFamiTF331063.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026946. Sialidase-4.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF8. PTHR10628:SF8. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q503Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSQYYPARS ILFQKEPSGV TYRVPALIYI PRSSCFLAFC EERLTPADAQ
60 70 80 90 100
AHLLVMRKGT FYKNYVEWKD MEVLSTARLE GYRSMNPCPV YDEFTDTIFL
110 120 130 140 150
FFIAVLGHTS ESYQLITGKN VTRLCYVSSC DQGDTWSNAT DLTRTLIGDT
160 170 180 190 200
IKEWATFAVG PGHGTQLKSG RLIIPAYAYH IDCRNCFGKT CKTSPHSFCF
210 220 230 240 250
YSDTHGNVWH FGQALSEPNS VECQMVSVDE EDGVNLLYCN ARSISGYRVQ
260 270 280 290 300
AVSFDHGTFF QDGQLVHKLL EPRNGCHGSV IGFPAPIFQL ERFKSIYNSL
310 320 330 340 350
ELSAAPRSPK NFLPPTWVVY SHPTCPNSRR DLGVYLSLLP RDPDSWSGPW
360 370 380 390 400
IIYDGPSAYS DLAYVDLMSS DAAGVTVFAC LFESGTKTAY DEISFCIFTL
410 420
YELIDHLPQD QEKTTLLKRK RIWERCFIC
Length:429
Mass (Da):48,517
Last modified:June 6, 2005 - v1
Checksum:iB32252C2305F2317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU694447 Genomic DNA. No translation available.
BC095117 mRNA. Translation: AAH95117.1.
BC165570 mRNA. Translation: AAI65570.1.
EF116275 mRNA. Translation: ABO45315.1.
RefSeqiNP_001018384.1. NM_001020548.2.
UniGeneiDr.89238.

Genome annotation databases

EnsembliENSDART00000080398; ENSDARP00000074848; ENSDARG00000057677.
GeneIDi553569.
KEGGidre:553569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU694447 Genomic DNA. No translation available.
BC095117 mRNA. Translation: AAH95117.1.
BC165570 mRNA. Translation: AAI65570.1.
EF116275 mRNA. Translation: ABO45315.1.
RefSeqiNP_001018384.1. NM_001020548.2.
UniGeneiDr.89238.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000074848.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000080398; ENSDARP00000074848; ENSDARG00000057677.
GeneIDi553569.
KEGGidre:553569.

Organism-specific databases

CTDi129807.
ZFINiZDB-GENE-050522-125. neu4.

Phylogenomic databases

eggNOGiNOG84455.
GeneTreeiENSGT00390000011171.
HOGENOMiHOG000233778.
HOVERGENiHBG052608.
InParanoidiQ503Z4.
KOiK12357.
OMAiHIDCKEC.
OrthoDBiEOG7MSMNP.
PhylomeDBiQ503Z4.
TreeFamiTF331063.

Enzyme and pathway databases

ReactomeiREACT_324112. Glycosphingolipid metabolism.
REACT_348107. Sialic acid metabolism.

Miscellaneous databases

NextBioi20880308.
PROiQ503Z4.

Gene expression databases

BgeeiQ503Z4.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026946. Sialidase-4.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF8. PTHR10628:SF8. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EyeImported.
  2. "Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio)."
    Manzoni M., Colombi P., Papini N., Rubaga L., Tiso N., Preti A., Venerando B., Tettamanti G., Bresciani R., Argenton F., Borsani G., Monti E.
    Biochem. J. 408:395-406(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ503Z4_DANRE
AccessioniPrimary (citable) accession number: Q503Z4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 6, 2005
Last sequence update: June 6, 2005
Last modified: March 31, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.