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Q503Z4

- Q503Z4_DANRE

UniProt

Q503Z4 - Q503Z4_DANRE

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Protein
Submitted name:

Neu4

Gene

neu4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: ZFIN

GO - Biological processi

  1. ganglioside metabolic process Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_221391. Glycosphingolipid metabolism.
REACT_221720. Sialic acid metabolism.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Neu4Imported
Submitted name:
Neu4 proteinImported
Submitted name:
Sialidase 4Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:neu4Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 15

Organism-specific databases

ZFINiZDB-GENE-050522-125. neu4.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: ZFIN
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000074848.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG84455.
GeneTreeiENSGT00390000011171.
HOGENOMiHOG000233778.
HOVERGENiHBG052608.
KOiK12357.
OMAiMNPCPVL.
OrthoDBiEOG7MSMNP.
TreeFamiTF331063.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026946. Sialidase-4.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF8. PTHR10628:SF8. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q503Z4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSQYYPARS ILFQKEPSGV TYRVPALIYI PRSSCFLAFC EERLTPADAQ
60 70 80 90 100
AHLLVMRKGT FYKNYVEWKD MEVLSTARLE GYRSMNPCPV YDEFTDTIFL
110 120 130 140 150
FFIAVLGHTS ESYQLITGKN VTRLCYVSSC DQGDTWSNAT DLTRTLIGDT
160 170 180 190 200
IKEWATFAVG PGHGTQLKSG RLIIPAYAYH IDCRNCFGKT CKTSPHSFCF
210 220 230 240 250
YSDTHGNVWH FGQALSEPNS VECQMVSVDE EDGVNLLYCN ARSISGYRVQ
260 270 280 290 300
AVSFDHGTFF QDGQLVHKLL EPRNGCHGSV IGFPAPIFQL ERFKSIYNSL
310 320 330 340 350
ELSAAPRSPK NFLPPTWVVY SHPTCPNSRR DLGVYLSLLP RDPDSWSGPW
360 370 380 390 400
IIYDGPSAYS DLAYVDLMSS DAAGVTVFAC LFESGTKTAY DEISFCIFTL
410 420
YELIDHLPQD QEKTTLLKRK RIWERCFIC
Length:429
Mass (Da):48,517
Last modified:June 7, 2005 - v1
Checksum:iB32252C2305F2317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU694447 Genomic DNA. No translation available.
BC095117 mRNA. Translation: AAH95117.1.
BC165570 mRNA. Translation: AAI65570.1.
EF116275 mRNA. Translation: ABO45315.1.
RefSeqiNP_001018384.1. NM_001020548.2.
XP_005169770.1. XM_005169713.1.
UniGeneiDr.89238.

Genome annotation databases

EnsembliENSDART00000080398; ENSDARP00000074848; ENSDARG00000057677.
GeneIDi553569.
KEGGidre:553569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU694447 Genomic DNA. No translation available.
BC095117 mRNA. Translation: AAH95117.1 .
BC165570 mRNA. Translation: AAI65570.1 .
EF116275 mRNA. Translation: ABO45315.1 .
RefSeqi NP_001018384.1. NM_001020548.2.
XP_005169770.1. XM_005169713.1.
UniGenei Dr.89238.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000074848.

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000080398 ; ENSDARP00000074848 ; ENSDARG00000057677 .
GeneIDi 553569.
KEGGi dre:553569.

Organism-specific databases

CTDi 129807.
ZFINi ZDB-GENE-050522-125. neu4.

Phylogenomic databases

eggNOGi NOG84455.
GeneTreei ENSGT00390000011171.
HOGENOMi HOG000233778.
HOVERGENi HBG052608.
KOi K12357.
OMAi MNPCPVL.
OrthoDBi EOG7MSMNP.
TreeFami TF331063.

Enzyme and pathway databases

Reactomei REACT_221391. Glycosphingolipid metabolism.
REACT_221720. Sialic acid metabolism.

Miscellaneous databases

NextBioi 20880308.
PROi Q503Z4.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR026946. Sialidase-4.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
PTHR10628:SF8. PTHR10628:SF8. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EyeImported.
  2. "Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio)."
    Manzoni M., Colombi P., Papini N., Rubaga L., Tiso N., Preti A., Venerando B., Tettamanti G., Bresciani R., Argenton F., Borsani G., Monti E.
    Biochem. J. 408:395-406(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ503Z4_DANRE
AccessioniPrimary (citable) accession number: Q503Z4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3