Q503W7 (ATD1B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATPase family AAA domain-containing protein 1-B
EC=3.6.1.3

Gene names

Name:	atad1b
ORF Names:	si:bz1g13.1, zgc:110042

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner By similarity.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subcellular location	Peroxisome By similarity. Cell junction › synapse › postsynaptic cell membrane By similarity.
Sequence similarities	Belongs to the AAA ATPase family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Peroxisome Postsynaptic cell membrane Synapse
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	ATPase family AAA domain-containing protein 1-B		PRO_0000084795
Regions
	Nucleotide binding	137 – 144	8	ATP Potential
Experimental info
	Sequence conflict	95	1	H → Y in AAH95151. Ref.2
	Sequence conflict	266	1	V → A in AAH95151. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q503W7 [UniParc]. Last modified September 13, 2005. Version 2. Checksum: 70136A5CC5CF05EC	FASTA	362	41,094
	10 20 30 40 50 60 MVLKEIPTEN ITRPLGRNEV IGLLFRLTIF GAVTYFTIKW MVDAIDPTRK QKVEAQKQAE 70 80 90 100 110 120 KLMRQIGVQN VKLSEYEMSI AAHLVDPLTM QITWHDIAGL DEVITELKDT VILPIQKRHL 130 140 150 160 170 180 FEGSRLLQPP KGVLLYGPPG CGKTLIAKAT AKEAGFRFIN LQPSTLTDKW YGESQKLAAA 190 200 210 220 230 240 VFSLAIKLQP SIIFIDEIDS FLRNRSSSDH EATAMMKAQF MSLWDGLDTD YNCQVIIMGA 250 260 270 280 290 300 TNRPQDLDSA ILRRMPTRFH INQPNVRQRK DILKLILENE NVESAVELSE IAKQTDGFSG 310 320 330 340 350 360 SDLREMCRDA ALLCVRDFVH QESPEEDFIR PIRQEDLQRA IEKMKKSKSA GVHEAFMQVP LD

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-281. Strain: Tuebingen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC095151 mRNA. Translation: AAH95151.1. AL731788 Genomic DNA. Translation: CAI11460.1.
IPI	IPI00487088.
RefSeq	NP_001019592.1. NM_001024421.2.
UniGene	Dr.78224.
3D structure databases
ProteinModelPortal	Q503W7.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000073585.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000079130; ENSDARP00000073585; ENSDARG00000056609. ENSDART00000140927; ENSDARP00000122459; ENSDARG00000056609.
GeneID	368412.
KEGG	dre:368412.
Organism-specific databases
CTD	368412.
ZFIN	ZDB-GENE-030616-44. atad1b.
Phylogenomic databases
eggNOG	COG0464.
GeneTree	ENSGT00550000074823.
HOGENOM	HOG000225141.
HOVERGEN	HBG057074.
OMA	YQVGIAD.
OrthoDB	EOG412M5T.
Gene expression databases
Bgee	Q503W7.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. [Graphical view]
Pfam	PF00004. AAA. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00674. AAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20812908.

Entry information

Entry name

ATD1B_DANRE

Accession

Primary (citable) accession number: Q503W7
Secondary accession number(s): Q5SQM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	April 3, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program