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Q503W7

- ATD1B_DANRE

UniProt

Q503W7 - ATD1B_DANRE

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Protein
ATPase family AAA domain-containing protein 1-B
Gene
atad1b, si:bz1g13.1, zgc:110042
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi137 – 1448ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 1-B (EC:3.6.1.3)
Gene namesi
Name:atad1b
ORF Names:si:bz1g13.1, zgc:110042
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-030616-44. atad1b.

Subcellular locationi

Peroxisome By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. peroxisome Source: UniProtKB-SubCell
  3. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362ATPase family AAA domain-containing protein 1-B
PRO_0000084795Add
BLAST

Expressioni

Gene expression databases

BgeeiQ503W7.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073585.

Structurei

3D structure databases

ProteinModelPortaliQ503W7.

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00550000074823.
HOGENOMiHOG000225141.
HOVERGENiHBG057074.
OMAiQELILYA.
OrthoDBiEOG7SR4MJ.
PhylomeDBiQ503W7.
TreeFamiTF105016.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q503W7-1 [UniParc]FASTAAdd to Basket

« Hide

MVLKEIPTEN ITRPLGRNEV IGLLFRLTIF GAVTYFTIKW MVDAIDPTRK    50
QKVEAQKQAE KLMRQIGVQN VKLSEYEMSI AAHLVDPLTM QITWHDIAGL 100
DEVITELKDT VILPIQKRHL FEGSRLLQPP KGVLLYGPPG CGKTLIAKAT 150
AKEAGFRFIN LQPSTLTDKW YGESQKLAAA VFSLAIKLQP SIIFIDEIDS 200
FLRNRSSSDH EATAMMKAQF MSLWDGLDTD YNCQVIIMGA TNRPQDLDSA 250
ILRRMPTRFH INQPNVRQRK DILKLILENE NVESAVELSE IAKQTDGFSG 300
SDLREMCRDA ALLCVRDFVH QESPEEDFIR PIRQEDLQRA IEKMKKSKSA 350
GVHEAFMQVP LD 362
Length:362
Mass (Da):41,094
Last modified:September 13, 2005 - v2
Checksum:i70136A5CC5CF05EC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951H → Y in AAH95151. 1 Publication
Sequence conflicti266 – 2661V → A in AAH95151. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC095151 mRNA. Translation: AAH95151.1.
AL731788 Genomic DNA. Translation: CAI11460.1.
RefSeqiNP_001019592.1. NM_001024421.2.
UniGeneiDr.78224.

Genome annotation databases

EnsembliENSDART00000079130; ENSDARP00000073585; ENSDARG00000056609.
GeneIDi368412.
KEGGidre:368412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC095151 mRNA. Translation: AAH95151.1 .
AL731788 Genomic DNA. Translation: CAI11460.1 .
RefSeqi NP_001019592.1. NM_001024421.2.
UniGenei Dr.78224.

3D structure databases

ProteinModelPortali Q503W7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000073585.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000079130 ; ENSDARP00000073585 ; ENSDARG00000056609 .
GeneIDi 368412.
KEGGi dre:368412.

Organism-specific databases

CTDi 368412.
ZFINi ZDB-GENE-030616-44. atad1b.

Phylogenomic databases

eggNOGi COG0464.
GeneTreei ENSGT00550000074823.
HOGENOMi HOG000225141.
HOVERGENi HBG057074.
OMAi QELILYA.
OrthoDBi EOG7SR4MJ.
PhylomeDBi Q503W7.
TreeFami TF105016.

Miscellaneous databases

NextBioi 20812908.
PROi Q503W7.

Gene expression databases

Bgeei Q503W7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-281.
    Strain: Tuebingen.

Entry informationi

Entry nameiATD1B_DANRE
AccessioniPrimary (citable) accession number: Q503W7
Secondary accession number(s): Q5SQM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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