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Q503W7

- ATD1B_DANRE

UniProt

Q503W7 - ATD1B_DANRE

Protein

ATPase family AAA domain-containing protein 1-B

Gene

atad1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi137 – 1448ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATPase family AAA domain-containing protein 1-B (EC:3.6.1.3)
    Gene namesi
    Name:atad1b
    ORF Names:si:bz1g13.1, zgc:110042
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 12

    Organism-specific databases

    ZFINiZDB-GENE-030616-44. atad1b.

    Subcellular locationi

    Peroxisome By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. peroxisome Source: UniProtKB-SubCell
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362ATPase family AAA domain-containing protein 1-BPRO_0000084795Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ503W7.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000073585.

    Structurei

    3D structure databases

    ProteinModelPortaliQ503W7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Phylogenomic databases

    eggNOGiCOG0464.
    GeneTreeiENSGT00550000074823.
    HOGENOMiHOG000225141.
    HOVERGENiHBG057074.
    OMAiQELILYA.
    OrthoDBiEOG7SR4MJ.
    PhylomeDBiQ503W7.
    TreeFamiTF105016.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q503W7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLKEIPTEN ITRPLGRNEV IGLLFRLTIF GAVTYFTIKW MVDAIDPTRK    50
    QKVEAQKQAE KLMRQIGVQN VKLSEYEMSI AAHLVDPLTM QITWHDIAGL 100
    DEVITELKDT VILPIQKRHL FEGSRLLQPP KGVLLYGPPG CGKTLIAKAT 150
    AKEAGFRFIN LQPSTLTDKW YGESQKLAAA VFSLAIKLQP SIIFIDEIDS 200
    FLRNRSSSDH EATAMMKAQF MSLWDGLDTD YNCQVIIMGA TNRPQDLDSA 250
    ILRRMPTRFH INQPNVRQRK DILKLILENE NVESAVELSE IAKQTDGFSG 300
    SDLREMCRDA ALLCVRDFVH QESPEEDFIR PIRQEDLQRA IEKMKKSKSA 350
    GVHEAFMQVP LD 362
    Length:362
    Mass (Da):41,094
    Last modified:September 13, 2005 - v2
    Checksum:i70136A5CC5CF05EC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951H → Y in AAH95151. (PubMed:23594743)Curated
    Sequence conflicti266 – 2661V → A in AAH95151. (PubMed:23594743)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC095151 mRNA. Translation: AAH95151.1.
    AL731788 Genomic DNA. Translation: CAI11460.1.
    RefSeqiNP_001019592.1. NM_001024421.2.
    UniGeneiDr.78224.

    Genome annotation databases

    EnsembliENSDART00000079130; ENSDARP00000073585; ENSDARG00000056609.
    GeneIDi368412.
    KEGGidre:368412.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC095151 mRNA. Translation: AAH95151.1 .
    AL731788 Genomic DNA. Translation: CAI11460.1 .
    RefSeqi NP_001019592.1. NM_001024421.2.
    UniGenei Dr.78224.

    3D structure databases

    ProteinModelPortali Q503W7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000073585.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000079130 ; ENSDARP00000073585 ; ENSDARG00000056609 .
    GeneIDi 368412.
    KEGGi dre:368412.

    Organism-specific databases

    CTDi 368412.
    ZFINi ZDB-GENE-030616-44. atad1b.

    Phylogenomic databases

    eggNOGi COG0464.
    GeneTreei ENSGT00550000074823.
    HOGENOMi HOG000225141.
    HOVERGENi HBG057074.
    OMAi QELILYA.
    OrthoDBi EOG7SR4MJ.
    PhylomeDBi Q503W7.
    TreeFami TF105016.

    Miscellaneous databases

    NextBioi 20812908.
    PROi Q503W7.

    Gene expression databases

    Bgeei Q503W7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-281.
      Strain: Tuebingen.

    Entry informationi

    Entry nameiATD1B_DANRE
    AccessioniPrimary (citable) accession number: Q503W7
    Secondary accession number(s): Q5SQM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3