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Protein
Submitted name:

Apolipoprotein Ea

Gene

apoea

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transportSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiR-DRE-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-DRE-8957275. Post-translational protein phosphorylation.
R-DRE-8963901. Chylomicron remodeling.
R-DRE-8964026. Chylomicron clearance.

Names & Taxonomyi

Protein namesi
Submitted name:
Apolipoprotein EaImported
Submitted name:
Zgc:110064Imported
Gene namesi
Name:apoeaImported
Synonyms:zgc:110064Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-010724-18. apoea.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501013900519 – 269Sequence analysisAdd BLAST251

Expressioni

Gene expression databases

BgeeiENSDARG00000086370.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110656.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili98 – 132Sequence analysisAdd BLAST35
Coiled coili193 – 242Sequence analysisAdd BLAST50

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
GeneTreeiENSGT00730000111315.
HOGENOMiHOG000034005.
HOVERGENiHBG105614.
KOiK04524.
OMAiIHAVETK.
OrthoDBiEOG091G0KAN.
TreeFamiTF334458.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Complete.

Q503V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFVAVIVAL AVISGCQGRF LFQDEPRSRW EEAVDQFWNH VSELTTRAEE
60 70 80 90 100
MRDNIKATQL GRELDTLISD SMMELQMYRD DLHSKLAPYA QERAQKFNED
110 120 130 140 150
LQLLVTKLRT HMEEAKDRVT EYTEELRTMV EQNSDELKNK ANSYAKKLRK
160 170 180 190 200
RFNKDIQEIN KKMSTYLEEV QSRASQSVED VKDRLEPYFT SMHERAQQKL
210 220 230 240 250
VNLREALRSQ AEEIKERLDS RMQELRDQVE KTKENVHNTL QQKAEDVQKW
260
FEPYVSHIQK QMEPVWESL
Length:269
Mass (Da):32,035
Last modified:June 7, 2005 - v1
Checksum:i885DEE50F698F679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU855694 Genomic DNA. No translation available.
BC095169 mRNA. Translation: AAH95169.1.
RefSeqiNP_001018401.1. NM_001020565.1.
UniGeneiDr.77157.

Genome annotation databases

EnsembliENSDART00000172219; ENSDARP00000133853; ENSDARG00000102004.
GeneIDi553587.
KEGGidre:553587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU855694 Genomic DNA. No translation available.
BC095169 mRNA. Translation: AAH95169.1.
RefSeqiNP_001018401.1. NM_001020565.1.
UniGeneiDr.77157.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000172219; ENSDARP00000133853; ENSDARG00000102004.
GeneIDi553587.
KEGGidre:553587.

Organism-specific databases

CTDi553587.
ZFINiZDB-GENE-010724-18. apoea.

Phylogenomic databases

eggNOGiENOG410IVK0. Eukaryota.
ENOG4111MYC. LUCA.
GeneTreeiENSGT00730000111315.
HOGENOMiHOG000034005.
HOVERGENiHBG105614.
KOiK04524.
OMAiIHAVETK.
OrthoDBiEOG091G0KAN.
TreeFamiTF334458.

Enzyme and pathway databases

ReactomeiR-DRE-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-DRE-8957275. Post-translational protein phosphorylation.
R-DRE-8963901. Chylomicron remodeling.
R-DRE-8964026. Chylomicron clearance.

Gene expression databases

BgeeiENSDARG00000086370.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ503V2_DANRE
AccessioniPrimary (citable) accession number: Q503V2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: June 7, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.