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Protein

60S ribosome subunit biogenesis protein NIP7 homolog

Gene

nip7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosome subunit biogenesis protein NIP7 homolog
Gene namesi
Name:nip7
ORF Names:zgc:110384
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-050522-256 nip7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003555671 – 18060S ribosome subunit biogenesis protein NIP7 homologAdd BLAST180

Proteomic databases

PaxDbiQ503P2

Expressioni

Gene expression databases

BgeeiENSDARG00000059075
ExpressionAtlasiQ503P2 baseline and differential

Interactioni

Subunit structurei

Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076524

Structurei

3D structure databases

ProteinModelPortaliQ503P2
SMRiQ503P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 170PUAPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 92N-terminal domainBy similarityAdd BLAST92
Regioni93 – 180C-terminal domainBy similarityAdd BLAST88

Sequence similaritiesi

Belongs to the NIP7 family.Curated

Phylogenomic databases

eggNOGiKOG3492 Eukaryota
COG1374 LUCA
GeneTreeiENSGT00390000003591
HOGENOMiHOG000168475
HOVERGENiHBG052625
InParanoidiQ503P2
KOiK07565
OMAiVVKAHVG
OrthoDBiEOG091G0NVA
PhylomeDBiQ503P2
TreeFamiTF300081

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR005155 Rbsml_synth_fac_NIP7-like
IPR016686 Ribosomal_synth_fac_NIP7
PfamiView protein in Pfam
PF03657 UPF0113, 1 hit
PIRSFiPIRSF017190 Rbsml_synth_fac_NIP7, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q503P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLTDEETK TMFEKLSKYI GENIKLLIDR PDGTYCFRLH NDRVYYMSEK
60 70 80 90 100
ILKLATNVSR DKLVSVGTCF GKFTKTQKFR LHITALDFLA PYAKFKVWVK
110 120 130 140 150
PGSEQSFLYG NHIMKSGLGR ITENTDKYQG VLVYSMADVP LGFGVAARTT
160 170 180
QECRKVDPMA IVVFHQADIG EYIRSEDTLT
Length:180
Mass (Da):20,609
Last modified:June 7, 2005 - v1
Checksum:i885308B3401BBCEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095238 mRNA Translation: AAH95238.1
RefSeqiNP_001018426.1, NM_001020590.1
UniGeneiDr.16108

Genome annotation databases

EnsembliENSDART00000082087; ENSDARP00000076524; ENSDARG00000059075
GeneIDi553616
KEGGidre:553616

Similar proteinsi

Entry informationi

Entry nameiNIP7_DANRE
AccessioniPrimary (citable) accession number: Q503P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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