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Protein

60S ribosome subunit biogenesis protein NIP7 homolog

Gene

nip7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosome subunit biogenesis protein NIP7 homolog
Gene namesi
Name:nip7
ORF Names:zgc:110384
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-050522-256. nip7.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003555671 – 18060S ribosome subunit biogenesis protein NIP7 homologAdd BLAST180

Proteomic databases

PaxDbiQ503P2.
PRIDEiQ503P2.

Expressioni

Gene expression databases

BgeeiENSDARG00000059075.
ExpressionAtlasiQ503P2. baseline.

Interactioni

Subunit structurei

Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076524.

Structurei

3D structure databases

ProteinModelPortaliQ503P2.
SMRiQ503P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 170PUAPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 92N-terminal domainBy similarityAdd BLAST92
Regioni93 – 180C-terminal domainBy similarityAdd BLAST88

Sequence similaritiesi

Belongs to the NIP7 family.Curated

Phylogenomic databases

eggNOGiKOG3492. Eukaryota.
COG1374. LUCA.
GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
HOVERGENiHBG052625.
InParanoidiQ503P2.
KOiK07565.
OMAiYCFREHR.
OrthoDBiEOG091G0NVA.
PhylomeDBiQ503P2.
TreeFamiTF300081.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
PfamiView protein in Pfam
PF03657. UPF0113. 1 hit.
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q503P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLTDEETK TMFEKLSKYI GENIKLLIDR PDGTYCFRLH NDRVYYMSEK
60 70 80 90 100
ILKLATNVSR DKLVSVGTCF GKFTKTQKFR LHITALDFLA PYAKFKVWVK
110 120 130 140 150
PGSEQSFLYG NHIMKSGLGR ITENTDKYQG VLVYSMADVP LGFGVAARTT
160 170 180
QECRKVDPMA IVVFHQADIG EYIRSEDTLT
Length:180
Mass (Da):20,609
Last modified:June 7, 2005 - v1
Checksum:i885308B3401BBCEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095238 mRNA. Translation: AAH95238.1.
RefSeqiNP_001018426.1. NM_001020590.1.
UniGeneiDr.16108.

Genome annotation databases

EnsembliENSDART00000082087; ENSDARP00000076524; ENSDARG00000059075.
GeneIDi553616.
KEGGidre:553616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095238 mRNA. Translation: AAH95238.1.
RefSeqiNP_001018426.1. NM_001020590.1.
UniGeneiDr.16108.

3D structure databases

ProteinModelPortaliQ503P2.
SMRiQ503P2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076524.

Proteomic databases

PaxDbiQ503P2.
PRIDEiQ503P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000082087; ENSDARP00000076524; ENSDARG00000059075.
GeneIDi553616.
KEGGidre:553616.

Organism-specific databases

CTDi51388.
ZFINiZDB-GENE-050522-256. nip7.

Phylogenomic databases

eggNOGiKOG3492. Eukaryota.
COG1374. LUCA.
GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
HOVERGENiHBG052625.
InParanoidiQ503P2.
KOiK07565.
OMAiYCFREHR.
OrthoDBiEOG091G0NVA.
PhylomeDBiQ503P2.
TreeFamiTF300081.

Miscellaneous databases

PROiPR:Q503P2.

Gene expression databases

BgeeiENSDARG00000059075.
ExpressionAtlasiQ503P2. baseline.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
PfamiView protein in Pfam
PF03657. UPF0113. 1 hit.
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIP7_DANRE
AccessioniPrimary (citable) accession number: Q503P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 7, 2005
Last modified: February 15, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.