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Q503I9

- GLD2_DANRE

UniProt

Q503I9 - GLD2_DANRE

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Protein
Poly(A) RNA polymerase GLD2
Gene
papd4, zgc:110560
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. May not play a role in replication-dependent histone mRNA degradation By similarity.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi219 – 2191Magnesium or manganese; catalytic By similarity
Metal bindingi221 – 2211Magnesium or manganese; catalytic By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. polynucleotide adenylyltransferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. RNA polyadenylation Source: UniProtKB
  2. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) RNA polymerase GLD2 (EC:2.7.7.19)
Alternative name(s):
PAP-associated domain-containing protein 4
Gene namesi
Name:papd4
ORF Names:zgc:110560
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050522-536. papd4.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Poly(A) RNA polymerase GLD2
PRO_0000341552Add
BLAST

Proteomic databases

PRIDEiQ503I9.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096574.

Structurei

3D structure databases

ProteinModelPortaliQ503I9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini386 – 44055PAP-associated
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5260.
HOGENOMiHOG000088606.
HOVERGENiHBG097533.
InParanoidiQ503I9.
KOiK14079.
PhylomeDBiQ503I9.

Family and domain databases

InterProiIPR002934. Nucleotidyltransferase.
IPR002058. PAP_assoc.
[Graphical view]
PfamiPF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q503I9-1 [UniParc]FASTAAdd to Basket

« Hide

MLPRPYIFSH NDGPSSHLFQ HVLPHNVSQQ QRIEAHLNST NNFIGPPMNA    50
PRFIPTYQWT PVELSDVACS PNGPMGNNRK RRIQDNSDIN LKRQRFSCPS 100
PHNQSARNSN FTSQPVTRPV TGREVTCPTC SSATFIPGGC VPSLGETCHQ 150
NAFSPSSVKD KLSQQILNLF FACEQQSDDL EKKESCRAAL QTDIQKIFPC 200
AKVFLGGSSL NGFGSRSSDA DLCLVIEEGP VNHRKDAVYV LSLVRKLLYK 250
LSYIEKPQLI RAKVPIVKFR DRISGVEFDL NFNNTVGIRN TFLLRTYAFV 300
EKRVRPLVLV IKKWANHHCI NDASRGTLSS YTLVLMVLHY LQTLPEPVIP 350
CLQRDYPTCF DPKMDIHLVP SGPSDIPAFV SRNQSSLGDL FLGFLRYYAT 400
VFKWDKQVIS VRMARTLPKS NCKEWKDKFI CVEEPFNRTN TARAVHERMK 450
FEAIKAAFIE SHRLLQLRKD LNFILPKSKQ MARPQTAPR 489
Length:489
Mass (Da):55,562
Last modified:June 7, 2005 - v1
Checksum:iE8C2FA195F44B8E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC095312 mRNA. Translation: AAH95312.1.
RefSeqiNP_001018436.1. NM_001020600.1.
UniGeneiDr.75639.

Genome annotation databases

GeneIDi553626.
KEGGidre:553626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC095312 mRNA. Translation: AAH95312.1 .
RefSeqi NP_001018436.1. NM_001020600.1.
UniGenei Dr.75639.

3D structure databases

ProteinModelPortali Q503I9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000096574.

Proteomic databases

PRIDEi Q503I9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 553626.
KEGGi dre:553626.

Organism-specific databases

CTDi 167153.
ZFINi ZDB-GENE-050522-536. papd4.

Phylogenomic databases

eggNOGi COG5260.
HOGENOMi HOG000088606.
HOVERGENi HBG097533.
InParanoidi Q503I9.
KOi K14079.
PhylomeDBi Q503I9.

Miscellaneous databases

NextBioi 20880363.

Family and domain databases

InterProi IPR002934. Nucleotidyltransferase.
IPR002058. PAP_assoc.
[Graphical view ]
Pfami PF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiGLD2_DANRE
AccessioniPrimary (citable) accession number: Q503I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 7, 2005
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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