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Q503I9 (GLD2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) RNA polymerase GLD2

EC=2.7.7.19
Alternative name(s):
PAP-associated domain-containing protein 4
Gene names
Name:papd4
ORF Names:zgc:110560
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. May not play a role in replication-dependent histone mRNA degradation By similarity.

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.

Contains 1 PAP-associated domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Poly(A) RNA polymerase GLD2
PRO_0000341552

Regions

Domain386 – 44055PAP-associated

Sites

Metal binding2191Magnesium or manganese; catalytic By similarity
Metal binding2211Magnesium or manganese; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q503I9 [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: E8C2FA195F44B8E3

FASTA48955,562
        10         20         30         40         50         60 
MLPRPYIFSH NDGPSSHLFQ HVLPHNVSQQ QRIEAHLNST NNFIGPPMNA PRFIPTYQWT 

        70         80         90        100        110        120 
PVELSDVACS PNGPMGNNRK RRIQDNSDIN LKRQRFSCPS PHNQSARNSN FTSQPVTRPV 

       130        140        150        160        170        180 
TGREVTCPTC SSATFIPGGC VPSLGETCHQ NAFSPSSVKD KLSQQILNLF FACEQQSDDL 

       190        200        210        220        230        240 
EKKESCRAAL QTDIQKIFPC AKVFLGGSSL NGFGSRSSDA DLCLVIEEGP VNHRKDAVYV 

       250        260        270        280        290        300 
LSLVRKLLYK LSYIEKPQLI RAKVPIVKFR DRISGVEFDL NFNNTVGIRN TFLLRTYAFV 

       310        320        330        340        350        360 
EKRVRPLVLV IKKWANHHCI NDASRGTLSS YTLVLMVLHY LQTLPEPVIP CLQRDYPTCF 

       370        380        390        400        410        420 
DPKMDIHLVP SGPSDIPAFV SRNQSSLGDL FLGFLRYYAT VFKWDKQVIS VRMARTLPKS 

       430        440        450        460        470        480 
NCKEWKDKFI CVEEPFNRTN TARAVHERMK FEAIKAAFIE SHRLLQLRKD LNFILPKSKQ 


MARPQTAPR 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC095312 mRNA. Translation: AAH95312.1.
RefSeqNP_001018436.1. NM_001020600.1.
UniGeneDr.75639.

3D structure databases

ProteinModelPortalQ503I9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000096574.

Proteomic databases

PRIDEQ503I9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID553626.
KEGGdre:553626.

Organism-specific databases

CTD167153.
ZFINZDB-GENE-050522-536. papd4.

Phylogenomic databases

eggNOGCOG5260.
HOGENOMHOG000088606.
HOVERGENHBG097533.
InParanoidQ503I9.
KOK14079.
PhylomeDBQ503I9.

Family and domain databases

InterProIPR002934. Nucleotidyltransferase.
IPR002058. PAP_assoc.
[Graphical view]
PfamPF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20880363.

Entry information

Entry nameGLD2_DANRE
AccessionPrimary (citable) accession number: Q503I9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 7, 2005
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families