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Q503I9

- GLD2_DANRE

UniProt

Q503I9 - GLD2_DANRE

Protein

Poly(A) RNA polymerase GLD2

Gene

papd4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. May not play a role in replication-dependent histone mRNA degradation By similarity.By similarity

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi219 – 2191Magnesium or manganese; catalyticBy similarity
    Metal bindingi221 – 2211Magnesium or manganese; catalyticBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. polynucleotide adenylyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA polyadenylation Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) RNA polymerase GLD2 (EC:2.7.7.19)
    Alternative name(s):
    PAP-associated domain-containing protein 4
    Gene namesi
    Name:papd4
    ORF Names:zgc:110560
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-050522-536. papd4.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Poly(A) RNA polymerase GLD2PRO_0000341552Add
    BLAST

    Proteomic databases

    PRIDEiQ503I9.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000096574.

    Structurei

    3D structure databases

    ProteinModelPortaliQ503I9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini386 – 44055PAP-associatedAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PAP-associated domain.Curated

    Phylogenomic databases

    eggNOGiCOG5260.
    HOGENOMiHOG000088606.
    HOVERGENiHBG097533.
    InParanoidiQ503I9.
    KOiK14079.
    PhylomeDBiQ503I9.

    Family and domain databases

    InterProiIPR002934. Nucleotidyltransferase.
    IPR002058. PAP_assoc.
    [Graphical view]
    PfamiPF01909. NTP_transf_2. 1 hit.
    PF03828. PAP_assoc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q503I9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPRPYIFSH NDGPSSHLFQ HVLPHNVSQQ QRIEAHLNST NNFIGPPMNA    50
    PRFIPTYQWT PVELSDVACS PNGPMGNNRK RRIQDNSDIN LKRQRFSCPS 100
    PHNQSARNSN FTSQPVTRPV TGREVTCPTC SSATFIPGGC VPSLGETCHQ 150
    NAFSPSSVKD KLSQQILNLF FACEQQSDDL EKKESCRAAL QTDIQKIFPC 200
    AKVFLGGSSL NGFGSRSSDA DLCLVIEEGP VNHRKDAVYV LSLVRKLLYK 250
    LSYIEKPQLI RAKVPIVKFR DRISGVEFDL NFNNTVGIRN TFLLRTYAFV 300
    EKRVRPLVLV IKKWANHHCI NDASRGTLSS YTLVLMVLHY LQTLPEPVIP 350
    CLQRDYPTCF DPKMDIHLVP SGPSDIPAFV SRNQSSLGDL FLGFLRYYAT 400
    VFKWDKQVIS VRMARTLPKS NCKEWKDKFI CVEEPFNRTN TARAVHERMK 450
    FEAIKAAFIE SHRLLQLRKD LNFILPKSKQ MARPQTAPR 489
    Length:489
    Mass (Da):55,562
    Last modified:June 7, 2005 - v1
    Checksum:iE8C2FA195F44B8E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC095312 mRNA. Translation: AAH95312.1.
    RefSeqiNP_001018436.1. NM_001020600.1.
    UniGeneiDr.75639.

    Genome annotation databases

    GeneIDi553626.
    KEGGidre:553626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC095312 mRNA. Translation: AAH95312.1 .
    RefSeqi NP_001018436.1. NM_001020600.1.
    UniGenei Dr.75639.

    3D structure databases

    ProteinModelPortali Q503I9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000096574.

    Proteomic databases

    PRIDEi Q503I9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 553626.
    KEGGi dre:553626.

    Organism-specific databases

    CTDi 167153.
    ZFINi ZDB-GENE-050522-536. papd4.

    Phylogenomic databases

    eggNOGi COG5260.
    HOGENOMi HOG000088606.
    HOVERGENi HBG097533.
    InParanoidi Q503I9.
    KOi K14079.
    PhylomeDBi Q503I9.

    Miscellaneous databases

    NextBioi 20880363.

    Family and domain databases

    InterProi IPR002934. Nucleotidyltransferase.
    IPR002058. PAP_assoc.
    [Graphical view ]
    Pfami PF01909. NTP_transf_2. 1 hit.
    PF03828. PAP_assoc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiGLD2_DANRE
    AccessioniPrimary (citable) accession number: Q503I9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3