Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q503I9

- GLD2_DANRE

UniProt

Q503I9 - GLD2_DANRE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Poly(A) RNA polymerase GLD2

Gene

papd4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. May not play a role in replication-dependent histone mRNA degradation (By similarity).By similarity

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi219 – 2191Magnesium or manganese; catalyticBy similarity
Metal bindingi221 – 2211Magnesium or manganese; catalyticBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. polynucleotide adenylyltransferase activity Source: UniProtKB

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. RNA polyadenylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) RNA polymerase GLD2 (EC:2.7.7.19)
Alternative name(s):
PAP-associated domain-containing protein 4
Gene namesi
Name:papd4
ORF Names:zgc:110560
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050522-536. papd4.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Poly(A) RNA polymerase GLD2PRO_0000341552Add
BLAST

Proteomic databases

PRIDEiQ503I9.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096574.

Structurei

3D structure databases

ProteinModelPortaliQ503I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini386 – 44055PAP-associatedAdd
BLAST

Sequence similaritiesi

Contains 1 PAP-associated domain.Curated

Phylogenomic databases

eggNOGiCOG5260.
HOGENOMiHOG000088606.
HOVERGENiHBG097533.
InParanoidiQ503I9.
KOiK14079.
PhylomeDBiQ503I9.

Family and domain databases

InterProiIPR002934. Nucleotidyltransferase.
IPR002058. PAP_assoc.
[Graphical view]
PfamiPF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q503I9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPRPYIFSH NDGPSSHLFQ HVLPHNVSQQ QRIEAHLNST NNFIGPPMNA
60 70 80 90 100
PRFIPTYQWT PVELSDVACS PNGPMGNNRK RRIQDNSDIN LKRQRFSCPS
110 120 130 140 150
PHNQSARNSN FTSQPVTRPV TGREVTCPTC SSATFIPGGC VPSLGETCHQ
160 170 180 190 200
NAFSPSSVKD KLSQQILNLF FACEQQSDDL EKKESCRAAL QTDIQKIFPC
210 220 230 240 250
AKVFLGGSSL NGFGSRSSDA DLCLVIEEGP VNHRKDAVYV LSLVRKLLYK
260 270 280 290 300
LSYIEKPQLI RAKVPIVKFR DRISGVEFDL NFNNTVGIRN TFLLRTYAFV
310 320 330 340 350
EKRVRPLVLV IKKWANHHCI NDASRGTLSS YTLVLMVLHY LQTLPEPVIP
360 370 380 390 400
CLQRDYPTCF DPKMDIHLVP SGPSDIPAFV SRNQSSLGDL FLGFLRYYAT
410 420 430 440 450
VFKWDKQVIS VRMARTLPKS NCKEWKDKFI CVEEPFNRTN TARAVHERMK
460 470 480
FEAIKAAFIE SHRLLQLRKD LNFILPKSKQ MARPQTAPR
Length:489
Mass (Da):55,562
Last modified:June 7, 2005 - v1
Checksum:iE8C2FA195F44B8E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095312 mRNA. Translation: AAH95312.1.
RefSeqiNP_001018436.1. NM_001020600.1.
UniGeneiDr.75639.

Genome annotation databases

GeneIDi553626.
KEGGidre:553626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095312 mRNA. Translation: AAH95312.1 .
RefSeqi NP_001018436.1. NM_001020600.1.
UniGenei Dr.75639.

3D structure databases

ProteinModelPortali Q503I9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000096574.

Proteomic databases

PRIDEi Q503I9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 553626.
KEGGi dre:553626.

Organism-specific databases

CTDi 167153.
ZFINi ZDB-GENE-050522-536. papd4.

Phylogenomic databases

eggNOGi COG5260.
HOGENOMi HOG000088606.
HOVERGENi HBG097533.
InParanoidi Q503I9.
KOi K14079.
PhylomeDBi Q503I9.

Miscellaneous databases

NextBioi 20880363.

Family and domain databases

InterProi IPR002934. Nucleotidyltransferase.
IPR002058. PAP_assoc.
[Graphical view ]
Pfami PF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiGLD2_DANRE
AccessioniPrimary (citable) accession number: Q503I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 7, 2005
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3