Q503G5 (Q503G5_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GMP reductase RuleBase RU003929
EC=1.7.1.7 RuleBase RU003929

Gene names

Name:

gmpr ZFIN ZDB-GENE-050522-48 Ensembl ENSDARP00000050129

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. RuleBase RU003929
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. RuleBase RU003929
Sequence similarities	Belongs to the IMPDH/GMPR family. RuleBase RU003927

Ontologies

Keywords
Ligand	Metal-binding RuleBase RU003929 NADP RuleBase RU003929 Potassium RuleBase RU003929
Molecular function	Oxidoreductase RuleBase RU003927
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	GMP reductase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q503G5 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: 9FD9F99740E58732	FASTA	345	37,565
	10 20 30 40 50 60 MPRVDADLKL DFKDVLFRPK RSSLKSRSEV DLQRTFTFRN SKQTYNGIPI IAANMDTTGT 70 80 90 100 110 120 FEIAQVLSKH TLFTAIQKHY SLEEWKTFAA NHPECLEHVA ASSGSGAADL EKLCSILEAI 130 140 150 160 170 180 PLIQYICLDV ANGYSEHFVE FVKRVRERFP KHTIMAGNVV TGEMVEELIL SGADIIKVGI 190 200 210 220 230 240 GPGSVCTTRI KTGVGYPQLS AVIECADSAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM 250 260 270 280 290 300 LGGMLAGHDQ CAGEVIEKDG KKFKLFYGMS SDTAMKKYVG GVAEYRASEG RTVQVPYKGD 310 320 330 340 VENTIRDILG GLRSTCTYVG AAKLKELSRR TTFIRVTQQS SHMFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Singapore local strain EMBL AAH95337.1. Tissue: Embryo EMBL AAH95337.1.
[2]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000050129.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000050129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX936306 Genomic DNA. No translation available. CR382336 Genomic DNA. No translation available. BC095337 mRNA. Translation: AAH95337.1.
IPI	IPI00505103.
RefSeq	NP_001018448.1. NM_001020612.1.
UniGene	Dr.45532.
3D structure databases
SMR	Q503G5. Positions 2-338.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000050129.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000050130; ENSDARP00000050129; ENSDARG00000016160.
GeneID	553639.
KEGG	dre:553639.
Organism-specific databases
CTD	2766.
ZFIN	ZDB-GENE-050522-48. gmpr.
Phylogenomic databases
eggNOG	COG0516.
GeneTree	ENSGT00530000062923.
HOGENOM	HOG000165756.
HOVERGEN	HBG051744.
InParanoid	Q503G5.
KO	K00364.
OMA	AYKEYFG.
OrthoDB	EOG4FXR7V.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR005993. GMP_reduct1. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF000235. GMP_reductase. 1 hit.
TIGRFAMs	TIGR01305. GMP_reduct_1. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20880373.

Entry information

Entry name

Q503G5_DANRE

Accession

Primary (citable) accession number: Q503G5

Entry history

Integrated into UniProtKB/TrEMBL:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)