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Protein
Submitted name:

Thyroid peroxidase

Gene

TPO

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, PeroxidaseImported

Protein family/group databases

PeroxiBasei3318. HsTPO01.

Names & Taxonomyi

Protein namesi
Submitted name:
Thyroid peroxidaseImported
Gene namesi
Name:TPOImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei849 – 871HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36694.

Protein family/group databases

Allergomei9554. Hom s TPO.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500424750819 – 933Sequence analysisAdd BLAST915

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ502Y3.
PeptideAtlasiQ502Y3.
PRIDEiQ502Y3.

Expressioni

Gene expression databases

GenevisibleiQ502Y3. HS.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini740 – 796Sushi (CCP/SCR)InterPro annotationAdd BLAST57
Domaini796 – 839EGF-likeInterPro annotationAdd BLAST44

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2408. Eukaryota.
ENOG410XPZ3. LUCA.
HOVERGENiHBG000071.
KOiK00431.

Family and domain databases

CDDicd00033. CCP. 1 hit.
Gene3Di1.10.640.10. 1 hit.
InterProiView protein in InterPro
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR000436. Sushi_SCR_CCP_dom.
IPR029589. TPO.
PANTHERiPTHR11475:SF89. PTHR11475:SF89. 1 hit.
PfamiView protein in Pfam
PF03098. An_peroxidase. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00084. Sushi. 1 hit.
PRINTSiPR00457. ANPEROXIDASE.
SMARTiView protein in SMART
SM00032. CCP. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SUPFAMiSSF48113. SSF48113. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
PS50923. SUSHI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q502Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV
60 70 80 90 100
DTAMYATMQR NLKKRGILSA AQLLSFSKLP EPTSGVIARA AEIMETSIQA
110 120 130 140 150
MKRKVNLKTQ QSQHPTDALS EDLLSIIANM SGCLPYMLPP KCPNTCLANK
160 170 180 190 200
YRPITGACNN RDHPRWGASN TALARWLPPV YEDGFSQPRG WNPGFLYNGF
210 220 230 240 250
PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD IAFTPQSTSK
260 270 280 290 300
AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD
310 320 330 340 350
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL
360 370 380 390 400
RVHARLRDSG RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV
410 420 430 440 450
PSLTALHTLW LREHNRLAAA LKALNAHWSA DAVYQEARKV VGALHQIITL
460 470 480 490 500
RDYIPRILGP EAFQQYVGPY EGYDSTANPT VSNVFSTAAF RFGHATIHPL
510 520 530 540 550
VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR GLLARPAKLQ
560 570 580 590 600
VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL
610 620 630 640 650
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG
660 670 680 690 700
PLFACLIGKQ MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG
710 720 730 740 750
LTRVPMDAFQ VGKFPEDFES CDSITGMNLE AWRETFPQDD KCGFPESVEN
760 770 780 790 800
GDFVHCEESG RRVLVYSCRH GYELQGREQL TCTQEGWDFQ PPLCKDVNEC
810 820 830 840 850
ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD SGRLPRVTWI
860 870 880 890 900
SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ
910 920 930
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL
Length:933
Mass (Da):102,937
Last modified:June 7, 2005 - v1
Checksum:iC0148BC7787238E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095448 mRNA. Translation: AAH95448.1.
RefSeqiNP_000538.3. NM_000547.5.
NP_001193673.1. NM_001206744.1.
NP_783650.1. NM_175719.3.
NP_783653.1. NM_175722.3.
UniGeneiHs.467554.

Genome annotation databases

GeneIDi7173.
KEGGihsa:7173.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ502Y3_HUMAN
AccessioniPrimary (citable) accession number: Q502Y3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: July 5, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation