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Protein
Submitted name:

Thyroid peroxidase

Gene

TPO

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, PeroxidaseImported

Protein family/group databases

PeroxiBasei3318 HsTPO01

Names & Taxonomyi

Protein namesi
Submitted name:
Thyroid peroxidaseImported
Gene namesi
Name:TPOImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei849 – 871HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36694

Protein family/group databases

Allergomei9554 Hom s TPO

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500424750819 – 933Sequence analysisAdd BLAST915

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiQ502Y3
PRIDEiQ502Y3

Expressioni

Gene expression databases

GenevisibleiQ502Y3 HS

Structurei

3D structure databases

SMRiQ502Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini740 – 796SushiInterPro annotationAdd BLAST57
Domaini796 – 839EGF-likeInterPro annotationAdd BLAST44

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, SignalSequence analysis, SushiPROSITE-ProRule annotationSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
HOVERGENiHBG000071
KOiK00431

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR029589 TPO
PANTHERiPTHR11475:SF60 PTHR11475:SF60, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF07645 EGF_CA, 1 hit
PF00084 Sushi, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SUPFAMiSSF48113 SSF48113, 1 hit
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
PS50292 PEROXIDASE_3, 1 hit
PS50923 SUSHI, 1 hit

Sequencei

Sequence statusi: Complete.

Q502Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV
60 70 80 90 100
DTAMYATMQR NLKKRGILSA AQLLSFSKLP EPTSGVIARA AEIMETSIQA
110 120 130 140 150
MKRKVNLKTQ QSQHPTDALS EDLLSIIANM SGCLPYMLPP KCPNTCLANK
160 170 180 190 200
YRPITGACNN RDHPRWGASN TALARWLPPV YEDGFSQPRG WNPGFLYNGF
210 220 230 240 250
PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD IAFTPQSTSK
260 270 280 290 300
AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD
310 320 330 340 350
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL
360 370 380 390 400
RVHARLRDSG RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV
410 420 430 440 450
PSLTALHTLW LREHNRLAAA LKALNAHWSA DAVYQEARKV VGALHQIITL
460 470 480 490 500
RDYIPRILGP EAFQQYVGPY EGYDSTANPT VSNVFSTAAF RFGHATIHPL
510 520 530 540 550
VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR GLLARPAKLQ
560 570 580 590 600
VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL
610 620 630 640 650
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG
660 670 680 690 700
PLFACLIGKQ MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG
710 720 730 740 750
LTRVPMDAFQ VGKFPEDFES CDSITGMNLE AWRETFPQDD KCGFPESVEN
760 770 780 790 800
GDFVHCEESG RRVLVYSCRH GYELQGREQL TCTQEGWDFQ PPLCKDVNEC
810 820 830 840 850
ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD SGRLPRVTWI
860 870 880 890 900
SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ
910 920 930
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL
Length:933
Mass (Da):102,937
Last modified:June 7, 2005 - v1
Checksum:iC0148BC7787238E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095448 mRNA Translation: AAH95448.1
RefSeqiNP_000538.3, NM_000547.5
NP_001193673.1, NM_001206744.1
NP_783650.1, NM_175719.3
NP_783653.1, NM_175722.3
UniGeneiHs.467554

Genome annotation databases

GeneIDi7173
KEGGihsa:7173

Similar proteinsi

Entry informationi

Entry nameiQ502Y3_HUMAN
AccessioniPrimary (citable) accession number: Q502Y3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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