Q502M1 (Q502M1_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Phosphoinositide-3-kinase, class 3 EMBL AAH95645.1

Gene names

Name:

pik3c3 ZFIN ZDB-GENE-050410-13

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAH95645.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	726 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PI3K/PI4K domain. SAAS SAAS018936 Contains 1 PIK helical domain. SAAS SAAS018936

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS008973 Nucleotide-binding
Molecular function	Kinase SAAS SAAS018936 EMBL AAH95645.1 Transferase
Gene Ontology (GO)
Biological_process	phosphatidylinositol-3-phosphate biosynthetic process Inferred from electronic annotation. Source: GOC phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro
Molecular_function	1-phosphatidylinositol-3-kinase activity Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q502M1 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: 6BFE620DDD88C4B4	FASTA	726	82,697
	10 20 30 40 50 60 MDTDKFNYVY SCDLDINVQL KIGSLEGKRE QKSYKALLED PMLRFSGLYQ ESCSDLYVTC 70 80 90 100 110 120 QAFAEGKPLA LPVRTSYKAF STRWNWNEWL RLPVKYPDLP QSAQVTLTVW DVYGPGRATP 130 140 150 160 170 180 VGGTTVTLFG KYGMFRQGMH DLKVWPGVEG DGTEPTSTPG RTSSSLAEDQ MGRLAKLTKA 190 200 210 220 230 240 HRQGHMVKVD WLDRLTFREI EMINESEKRS SNFMYLMVEF PRVKSGEREY SIVYYEKDAD 250 260 270 280 290 300 ESSPLPTSSD IVKVPDPQMC MENLVESKHH RLARSLRSGP SDHDLKPNAA TRDQLNIIVS 310 320 330 340 350 360 YPPTKQLSSE EQDLVWKFRY YLTTQEKALT KFLKCVNWDL PQEAKQALEL LGKWRPMDVE 370 380 390 400 410 420 DSLELLSSQF TNPTVRRYAV ARLQQADDED LLMYLLQLVQ ALKYENFNDI QGGLEPANKR 430 440 450 460 470 480 DNQGGLTESS TTGDLDSSQL ASAIAVMPSS QKGKEGTDGE NLEQDLCTFL ISRACKNSTL 490 500 510 520 530 540 ANYLYWYVIV ECEDQDTQQR DPKTHDMYLN VMRRFSQALL KGDKSVRVMR SLLASQQTFV 550 560 570 580 590 600 DRLVQLMKAV QRESGNRKKK TERSQSLLAD NEKVNLSEIE PIPLPLEPQI RIKGIIPETA 610 620 630 640 650 660 TLFKSALMPA KLIFKTEDGE QYPVIFKHGD DLRQDQLILQ IISLMDKLLR KENLDLKLTP 670 680 690 700 710 720 YKVLATSTKH GFMQFVQSVP VAEVLATEGN IQSFFRKYAP NDKGPYGISS EVMDTYVKSC DTPISF

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium EMBL AAH95645.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC095645 mRNA. Translation: AAH95645.1.
IPI	IPI00506373.
RefSeq	NP_001017550.2. NM_001017550.2.
UniGene	Dr.78335.
3D structure databases
ProteinModelPortal	Q502M1.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000092039.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	548346.
KEGG	dre:548346.
Organism-specific databases
CTD	5289.
ZFIN	ZDB-GENE-050410-13. pik3c3.
Phylogenomic databases
eggNOG	COG5032.
HOGENOM	HOG000174003.
HOVERGEN	HBG082145.
KO	K00914.
OrthoDB	EOG46T30T.
Family and domain databases
Gene3D	1.25.40.70. 2 hits.
InterPro	IPR016024. ARM-type_fold. IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR002420. PI3K_C2_dom. IPR008290. PI3K_Vps34. IPR015433. PI_Kinase. IPR001263. PInositide-3_kin_accessory_dom. [Graphical view]
PANTHER	PTHR10048. PTHR10048. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. PF00792. PI3K_C2. 1 hit. PF00613. PI3Ka. 1 hit. [Graphical view]
PIRSF	PIRSF000587. PI3K_Vps34. 1 hit.
SMART	SM00239. C2. 1 hit. SM00142. PI3K_C2. 1 hit. SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF49562. C2_CaLB. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00915. PI3_4_KINASE_1. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. PS51547. PI3K_C2. 1 hit. PS51545. PIK_HELICAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20879397.

Entry information

Entry name

Q502M1_DANRE

Accession

Primary (citable) accession number: Q502M1

Entry history

Integrated into UniProtKB/TrEMBL:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)