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Q502L2

- PGAM5_DANRE

UniProt

Q502L2 - PGAM5_DANRE

Protein

Serine/threonine-protein phosphatase PGAM5, mitochondrial

Gene

pgam5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics By similarity. May be a central mediator for programmed necrosis By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. programmed cell death Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Necrosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC:3.1.3.16)
    Alternative name(s):
    Phosphoglycerate mutase family member 5
    Gene namesi
    Name:pgam5
    ORF Names:si:dkey-69p22.1, zgc:92057
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 5

    Organism-specific databases

    ZFINiZDB-GENE-030131-683. pgam5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Serine/threonine-protein phosphatase PGAM5, mitochondrialPRO_0000288785Add
    BLAST

    Post-translational modificationi

    Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity By similarity.By similarity

    Expressioni

    Gene expression databases

    BgeeiQ502L2.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000051620.

    Structurei

    3D structure databases

    ProteinModelPortaliQ502L2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71348.
    GeneTreeiENSGT00390000004796.
    HOGENOMiHOG000261217.
    HOVERGENiHBG105576.
    InParanoidiQ502L2.
    KOiK15637.
    OMAiWLRMSLN.
    OrthoDBiEOG7966H1.
    PhylomeDBiQ502L2.
    TreeFamiTF314977.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q502L2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFRRALSLA CGFAGGSAVL VCAAVVADKN GYFGEGRRVT ETLAAVNAAH    50
    PPAWPTANGW DYNWDKREPS SMVNGKRKES TGENGSQDAE NNKPRATRHI 100
    FLIRHSQYNL KGDGDKERFL TPLGREQAEF TGQRLASFGL KYDTLIHSSM 150
    TRATETANII SKYLPGVELV SCDLLREGAP IEPVPPVTHW KPEAVQYHED 200
    GARIEAAFRR YIHRADAKQK EDSYEIIVCH ANVIRYFVCR ALQFPPEGWL 250
    RLGLNNGSIT WLTVRPSGRV SLRALGDSGF MPPDKLTRT 289
    Length:289
    Mass (Da):32,173
    Last modified:May 29, 2007 - v2
    Checksum:i798F3A77AEFF0078
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821G → S in AAH95654. 1 PublicationCurated
    Sequence conflicti89 – 891A → G in AAH85627. 1 PublicationCurated
    Sequence conflicti92 – 921N → T in AAH95654. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR388061 Genomic DNA. Translation: CAM16277.1.
    BC085627 mRNA. Translation: AAH85627.1.
    BC095654 mRNA. Translation: AAH95654.1.
    RefSeqiNP_001007324.2. NM_001007323.2.
    UniGeneiDr.104263.

    Genome annotation databases

    EnsembliENSDART00000051621; ENSDARP00000051620; ENSDARG00000035608.
    GeneIDi492357.
    KEGGidre:492357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR388061 Genomic DNA. Translation: CAM16277.1 .
    BC085627 mRNA. Translation: AAH85627.1 .
    BC095654 mRNA. Translation: AAH95654.1 .
    RefSeqi NP_001007324.2. NM_001007323.2.
    UniGenei Dr.104263.

    3D structure databases

    ProteinModelPortali Q502L2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000051620.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000051621 ; ENSDARP00000051620 ; ENSDARG00000035608 .
    GeneIDi 492357.
    KEGGi dre:492357.

    Organism-specific databases

    CTDi 192111.
    ZFINi ZDB-GENE-030131-683. pgam5.

    Phylogenomic databases

    eggNOGi NOG71348.
    GeneTreei ENSGT00390000004796.
    HOGENOMi HOG000261217.
    HOVERGENi HBG105576.
    InParanoidi Q502L2.
    KOi K15637.
    OMAi WLRMSLN.
    OrthoDBi EOG7966H1.
    PhylomeDBi Q502L2.
    TreeFami TF314977.

    Miscellaneous databases

    NextBioi 20864923.
    PROi Q502L2.

    Gene expression databases

    Bgeei Q502L2.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiPGAM5_DANRE
    AccessioniPrimary (citable) accession number: Q502L2
    Secondary accession number(s): A2CEB1, Q5U3B2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3