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Protein

Serine/threonine-protein phosphatase PGAM5, mitochondrial

Gene

pgam5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics (By similarity). May be a central mediator for programmed necrosis (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNecrosis

Enzyme and pathway databases

ReactomeiR-DRE-8934903 Receptor Mediated Mitophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5
Gene namesi
Name:pgam5
ORF Names:si:dkey-69p22.1, zgc:92057
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-030131-683 pgam5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 27HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002887851 – 289Serine/threonine-protein phosphatase PGAM5, mitochondrialAdd BLAST289

Post-translational modificationi

Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity (By similarity).By similarity

Proteomic databases

PaxDbiQ502L2

Expressioni

Gene expression databases

BgeeiENSDARG00000035608

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000051620

Structurei

3D structure databases

ProteinModelPortaliQ502L2
SMRiQ502L2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4609 Eukaryota
ENOG410XXCQ LUCA
GeneTreeiENSGT00390000004796
HOGENOMiHOG000261217
HOVERGENiHBG105576
InParanoidiQ502L2
KOiK15637
OMAiWLTIRPS
OrthoDBiEOG091G0DEJ
PhylomeDBiQ502L2
TreeFamiTF314977

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit

Sequencei

Sequence statusi: Complete.

Q502L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRRALSLA CGFAGGSAVL VCAAVVADKN GYFGEGRRVT ETLAAVNAAH
60 70 80 90 100
PPAWPTANGW DYNWDKREPS SMVNGKRKES TGENGSQDAE NNKPRATRHI
110 120 130 140 150
FLIRHSQYNL KGDGDKERFL TPLGREQAEF TGQRLASFGL KYDTLIHSSM
160 170 180 190 200
TRATETANII SKYLPGVELV SCDLLREGAP IEPVPPVTHW KPEAVQYHED
210 220 230 240 250
GARIEAAFRR YIHRADAKQK EDSYEIIVCH ANVIRYFVCR ALQFPPEGWL
260 270 280
RLGLNNGSIT WLTVRPSGRV SLRALGDSGF MPPDKLTRT
Length:289
Mass (Da):32,173
Last modified:May 29, 2007 - v2
Checksum:i798F3A77AEFF0078
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82G → S in AAH95654 (Ref. 2) Curated1
Sequence conflicti89A → G in AAH85627 (Ref. 2) Curated1
Sequence conflicti92N → T in AAH95654 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR388061 Genomic DNA Translation: CAM16277.1
BC085627 mRNA Translation: AAH85627.1
BC095654 mRNA Translation: AAH95654.1
RefSeqiNP_001007324.2, NM_001007323.2
UniGeneiDr.104263

Genome annotation databases

EnsembliENSDART00000051621; ENSDARP00000051620; ENSDARG00000035608
GeneIDi492357
KEGGidre:492357

Similar proteinsi

Entry informationi

Entry nameiPGAM5_DANRE
AccessioniPrimary (citable) accession number: Q502L2
Secondary accession number(s): A2CEB1, Q5U3B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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