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Q50299

- KAD_MYCPN

UniProt

Q50299 - KAD_MYCPN

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Protein
Adenylate kinase
Gene
adk, MPN_185, MP646
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism By similarity.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351AMP By similarity
Binding sitei40 – 401AMP By similarity
Binding sitei98 – 981AMP By similarity
Binding sitei129 – 1291ATP By similarity
Metal bindingi132 – 1321Zinc; structural By similarity
Metal bindingi135 – 1351Zinc; structural By similarity
Metal bindingi152 – 1521Zinc; structural By similarity
Metal bindingi155 – 1551Zinc; structural By similarity
Binding sitei162 – 1621AMP By similarity
Binding sitei173 – 1731AMP By similarity
Binding sitei211 – 2111ATP; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 196ATP By similarity
Nucleotide bindingi61 – 633AMP By similarity
Nucleotide bindingi91 – 944AMP By similarity
Nucleotide bindingi138 – 1392ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. adenylate kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. AMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-192-MONOMER.
UniPathwayiUPA00588; UER00649.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase (EC:2.7.4.3)
Short name:
AK
Alternative name(s):
ATP-AMP transphosphorylase
ATP:AMP phosphotransferase
Adenylate monophosphate kinase
Gene namesi
Name:adk
Ordered Locus Names:MPN_185
ORF Names:MP646
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Adenylate kinaseUniRule annotation
PRO_0000158804Add
BLAST

Proteomic databases

PaxDbiQ50299.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ50299. 1 interaction.
STRINGi272634.MPN185.

Structurei

3D structure databases

ProteinModelPortaliQ50299.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 6330NMPbind By similarity
Add
BLAST
Regioni128 – 16538LID By similarity
Add
BLAST

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the adenylate kinase family.

Phylogenomic databases

eggNOGiCOG0563.
KOiK00939.
OMAiDYVINIK.
OrthoDBiEOG679TH4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk.
InterProiIPR006259. Adenyl_kin_sub.
IPR000850. Adenylat/UMP-CMP_kin.
IPR007862. Adenylate_kinase_lid-dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PfamiPF05191. ADK_lid. 1 hit.
[Graphical view]
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF57774. SSF57774. 1 hit.
TIGRFAMsiTIGR01351. adk. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50299-1 [UniParc]FASTAAdd to Basket

« Hide

MVMENKFLFL GAPGVGKGTL AKQVANTTGL FHLSTGDIFR SVMQEQGALS    50
QTLAHYMNQG LYVPDELTNQ TFWHFVTTHQ NELHKGFILD GYPRTLNQLE 100
FLQSKLQLDQ VFHLKLSDPQ VLVARILNRL VCPSCGSVYN KQSKPPLKAN 150
QCDRCHATLQ ARNDDTEAVI LKRLTLYEDT VKPLIEAFTK QGILTVIEAQ 200
LPLEQQVNLV QQLVH 215
Length:215
Mass (Da):24,255
Last modified:November 1, 1997 - v1
Checksum:i3F4258BEFA24E8E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34795 Genomic DNA. Translation: AAC43696.1.
U00089 Genomic DNA. Translation: AAB96294.1.
PIRiS62823.
RefSeqiNP_109873.1. NC_000912.1.
WP_010874542.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96294; AAB96294; MPN_185.
GeneIDi876756.
KEGGimpn:MPN185.
PATRICi20021693. VBIMycPne110_0203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34795 Genomic DNA. Translation: AAC43696.1 .
U00089 Genomic DNA. Translation: AAB96294.1 .
PIRi S62823.
RefSeqi NP_109873.1. NC_000912.1.
WP_010874542.1. NC_000912.1.

3D structure databases

ProteinModelPortali Q50299.
ModBasei Search...

Protein-protein interaction databases

IntActi Q50299. 1 interaction.
STRINGi 272634.MPN185.

Proteomic databases

PaxDbi Q50299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96294 ; AAB96294 ; MPN_185 .
GeneIDi 876756.
KEGGi mpn:MPN185.
PATRICi 20021693. VBIMycPne110_0203.

Phylogenomic databases

eggNOGi COG0563.
KOi K00939.
OMAi DYVINIK.
OrthoDBi EOG679TH4.

Enzyme and pathway databases

UniPathwayi UPA00588 ; UER00649 .
BioCyci MPNE272634:GJ6Z-192-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00235. Adenylate_kinase_Adk.
InterProi IPR006259. Adenyl_kin_sub.
IPR000850. Adenylat/UMP-CMP_kin.
IPR007862. Adenylate_kinase_lid-dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR23359. PTHR23359. 1 hit.
Pfami PF05191. ADK_lid. 1 hit.
[Graphical view ]
PRINTSi PR00094. ADENYLTKNASE.
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF57774. SSF57774. 1 hit.
TIGRFAMsi TIGR01351. adk. 1 hit.
PROSITEi PS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a cluster of ribosomal protein genes."
    Hilbert H., Himmelreich R., Plagens H., Herrmann R.
    Nucleic Acids Res. 24:628-639(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29342 / M129.
  2. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiKAD_MYCPN
AccessioniPrimary (citable) accession number: Q50299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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