Q50299 (KAD_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adk
Ordered Locus Names:	MPN_185
ORF Names:	MP646

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP-Rule MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP-Rule MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP-Rule MF_00235
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm HAMAP-Rule MF_00235.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP-Rule MF_00235
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	AMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Adenylate kinase HAMAP-Rule MF_00235		PRO_0000158804
Regions
	Nucleotide binding	11 – 19	9	ATP By similarity
	Nucleotide binding	35 – 63	29	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q50299 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 3F4258BEFA24E8E8	FASTA	215	24,255
	10 20 30 40 50 60 MVMENKFLFL GAPGVGKGTL AKQVANTTGL FHLSTGDIFR SVMQEQGALS QTLAHYMNQG 70 80 90 100 110 120 LYVPDELTNQ TFWHFVTTHQ NELHKGFILD GYPRTLNQLE FLQSKLQLDQ VFHLKLSDPQ 130 140 150 160 170 180 VLVARILNRL VCPSCGSVYN KQSKPPLKAN QCDRCHATLQ ARNDDTEAVI LKRLTLYEDT 190 200 210 VKPLIEAFTK QGILTVIEAQ LPLEQQVNLV QQLVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a cluster of ribosomal protein genes." Hilbert H., Himmelreich R., Plagens H., Herrmann R. Nucleic Acids Res. 24:628-639(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 29342 / M129.
[2]	"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U34795 Genomic DNA. Translation: AAC43696.1. U00089 Genomic DNA. Translation: AAB96294.1.
PIR	S62823.
RefSeq	NP_109873.1. NC_000912.1.
3D structure databases
ProteinModelPortal	Q50299.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q50299. 1 interaction.
STRING	272634.MPN185.
Proteomic databases
PaxDb	Q50299.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB96294; AAB96294; MPN_185.
GeneID	876756.
KEGG	mpn:MPN185.
PATRIC	20021693. VBIMycPne110_0203.
Phylogenomic databases
eggNOG	COG0563.
KO	K00939.
OMA	FNLPGGI.
ProtClustDB	CLSK335171.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-564. MPNE272634:GJ6Z-192-MONOMER.
UniPathway	UPA00588; UER00649.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk.
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
PANTHER	PTHR23359. PTHR23359. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
SUPFAM	SSF57774. Adenylate_kinase_Znf_lid. 1 hit.
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD_MYCPN

Accession

Primary (citable) accession number: Q50299

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program