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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52NucleophileUniRule annotation1
Binding sitei110SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-313-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Synonyms:hisT
Ordered Locus Names:MPN_196
ORF Names:MP635
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000574131 – 243tRNA pseudouridine synthase AAdd BLAST243

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ50291
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

KOiK06173
OMAiKGVHANN

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 1 hit
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit

Sequencei

Sequence statusi: Complete.

Q50291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRYLAIVAY NGAPFRGWAK QPGYHTVQGQ IEQNLALIYQ TPINIYGSGR
60 70 80 90 100
TDKGVHAINQ TFHVDLPDKL PLKQLIAKLN QLNYPDIFVK ALVPVAPRFH
110 120 130 140 150
ARFAVKTKVY EYLINTRAFN PAQYHTVWQY NHPLDLAQLE ADTTLFLGRK
160 170 180 190 200
DFWSFSTASQ KDTQRTISKI IVQQDHTGTV KLTFFGNGFL RNQIRMMVAS
210 220 230 240
LVALNNRTLM RETVQQLFDQ PQKGGCKVKA PACGLYLKTV LYE
Length:243
Mass (Da):27,717
Last modified:November 1, 1996 - v1
Checksum:iA5DE0B36E226FF12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34795 Genomic DNA Translation: AAC43685.1
U00089 Genomic DNA Translation: AAB96283.1
PIRiS62812
RefSeqiNP_109884.1, NC_000912.1
WP_010874553.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB96283; AAB96283; MPN_196
GeneIDi876925
KEGGimpn:MPN196
PATRICifig|272634.6.peg.214

Similar proteinsi

Entry informationi

Entry nameiTRUA_MYCPN
AccessioniPrimary (citable) accession number: Q50291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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