Q50290 (Y198_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized adenine-specific methylase MPN_198
EC=2.1.1.72

Alternative name(s):
M.MpnIP

Gene names

Ordered Locus Names:	MPN_198
ORF Names:	GT9_orf319V, MP633

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.
Sequence similarities	Belongs to the N(4)/N(6)-methyltransferase family.

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA methylation on adenine Inferred from electronic annotation. Source: GOC
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro site-specific DNA-methyltransferase (adenine-specific) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Uncharacterized adenine-specific methylase MPN_198		PRO_0000088018

Sequences

	Sequence		Length	Mass (Da)
	Q50290 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C665CA40A958A78B	FASTA	319	36,870
	10 20 30 40 50 60 MHYFNRAKKA KNNEFYTLFE DIAAEVACYP NAFKGKVVLC NCNDGYQSNF WQFFQSQFHA 70 80 90 100 110 120 LGLKKLVAIA FNPLGNSYQL NFDGKEIKEL PLAGNGSFDS AEAIVLLKQS DIVVTNPPFS 130 140 150 160 170 180 LFQDFVCLLA EHGKQFLVLG HNGAVGYNQI FKLFKEEQLW YGHTVNSSML FQVQSNFKLY 190 200 210 220 230 240 DPKSVNFVKK DGQLFQKVPG ISWFTNLKKN QQPAWLKTKS RYQGNEHKYP KFDWYDAIFV 250 260 270 280 290 300 SKVKEIPLDW FGYMGVPLTF LNCFNPKQFE LIDCLANPYA TLDTLKTNAY VRSHHGDVRN 310 VKGKRRYVRV VIKQRQNVI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a cluster of ribosomal protein genes." Hilbert H., Himmelreich R., Plagens H., Herrmann R. Nucleic Acids Res. 24:628-639(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 29342 / M129.
[2]	"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U34795 Genomic DNA. Translation: AAC43683.1. U00089 Genomic DNA. Translation: AAB96281.1.
PIR	S62810.
RefSeq	NP_109886.1. NC_000912.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	272634.MPN198.
Protein family/group databases
REBASE	6710. M.MpnI.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB96281; AAB96281; MPN_198.
GeneID	876831.
KEGG	mpn:MPN198.
PATRIC	20021719. VBIMycPne110_0216.
Phylogenomic databases
eggNOG	NOG10100.
KO	K00571.
OMA	PNNCLWL.
ProtClustDB	CLSK2411656.
Enzyme and pathway databases
BioCyc	MPNE272634:GJ6Z-205-MONOMER.
Family and domain databases
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR025247. EcoRI_methylase. [Graphical view]
Pfam	PF13651. EcoRI_methylase. 2 hits. [Graphical view]
PROSITE	PS00092. N6_MTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y198_MYCPN

Accession

Primary (citable) accession number: Q50290

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program