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Protein

Uncharacterized adenine-specific methylase MPN_198

Gene

MPN_198

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-205-MONOMER.

Protein family/group databases

REBASEi6710. M.MpnI.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized adenine-specific methylase MPN_198 (EC:2.1.1.72)
Alternative name(s):
M.MpnIP
Gene namesi
Ordered Locus Names:MPN_198
ORF Names:GT9_orf319V, MP633
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Uncharacterized adenine-specific methylase MPN_198PRO_0000088018Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272634.MPN198.

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

eggNOGiNOG10100.
KOiK00571.
OMAiPNNCLWL.
OrthoDBiEOG60CWHX.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR025247. EcoRI_methylase.
[Graphical view]
PfamiPF13651. EcoRI_methylase. 2 hits.
[Graphical view]
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50290-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHYFNRAKKA KNNEFYTLFE DIAAEVACYP NAFKGKVVLC NCNDGYQSNF
60 70 80 90 100
WQFFQSQFHA LGLKKLVAIA FNPLGNSYQL NFDGKEIKEL PLAGNGSFDS
110 120 130 140 150
AEAIVLLKQS DIVVTNPPFS LFQDFVCLLA EHGKQFLVLG HNGAVGYNQI
160 170 180 190 200
FKLFKEEQLW YGHTVNSSML FQVQSNFKLY DPKSVNFVKK DGQLFQKVPG
210 220 230 240 250
ISWFTNLKKN QQPAWLKTKS RYQGNEHKYP KFDWYDAIFV SKVKEIPLDW
260 270 280 290 300
FGYMGVPLTF LNCFNPKQFE LIDCLANPYA TLDTLKTNAY VRSHHGDVRN
310
VKGKRRYVRV VIKQRQNVI
Length:319
Mass (Da):36,870
Last modified:November 1, 1996 - v1
Checksum:iC665CA40A958A78B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34795 Genomic DNA. Translation: AAC43683.1.
U00089 Genomic DNA. Translation: AAB96281.1.
PIRiS62810.
RefSeqiNP_109886.1. NC_000912.1.
WP_010874555.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96281; AAB96281; MPN_198.
GeneIDi876831.
KEGGimpn:MPN198.
PATRICi20021719. VBIMycPne110_0216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34795 Genomic DNA. Translation: AAC43683.1.
U00089 Genomic DNA. Translation: AAB96281.1.
PIRiS62810.
RefSeqiNP_109886.1. NC_000912.1.
WP_010874555.1. NC_000912.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272634.MPN198.

Protein family/group databases

REBASEi6710. M.MpnI.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB96281; AAB96281; MPN_198.
GeneIDi876831.
KEGGimpn:MPN198.
PATRICi20021719. VBIMycPne110_0216.

Phylogenomic databases

eggNOGiNOG10100.
KOiK00571.
OMAiPNNCLWL.
OrthoDBiEOG60CWHX.

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-205-MONOMER.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR025247. EcoRI_methylase.
[Graphical view]
PfamiPF13651. EcoRI_methylase. 2 hits.
[Graphical view]
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a cluster of ribosomal protein genes."
    Hilbert H., Himmelreich R., Plagens H., Herrmann R.
    Nucleic Acids Res. 24:628-639(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29342 / M129.
  2. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiY198_MYCPN
AccessioniPrimary (citable) accession number: Q50290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.