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Protein

V-set domain-containing T-cell activation inhibitor 1

Gene

Vtcn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
V-set domain-containing T-cell activation inhibitor 1
Gene namesi
Name:Vtcn1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1311204. Vtcn1.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

  • Note: Expressed at the cell surface. A soluble form has also been detected (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000033924025 – 257V-set domain-containing T-cell activation inhibitor 1Sequence analysisAdd BLAST233
PropeptideiPRO_0000339241258 – 282Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 130PROSITE-ProRule annotation
Disulfide bondi168 ↔ 225PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1
Lipidationi257GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ501W4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015279.
GenevisibleiQ501W4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020566.

Structurei

3D structure databases

ProteinModelPortaliQ501W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-type 1Sequence analysisAdd BLAST110
Domaini153 – 241Ig-like V-type 2Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. BTN/MOG family.By similarity
Contains 2 Ig-like V-type (immunoglobulin-like) domains.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IKB5. Eukaryota.
ENOG4111T2B. LUCA.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000139645.
HOVERGENiHBG097943.
InParanoidiQ501W4.
KOiK06747.
OMAiVDQGANF.
OrthoDBiEOG091G0IEZ.
PhylomeDBiQ501W4.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q501W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLGQIIFW SIINVIIILA GAIVLIIGFG ISGKHFITVT TFTSAGNIGE
60 70 80 90 100
DGTLSCTFEP DIKLNGIVIQ WLKEGIKGLV HEFKEGKDDL SQQHEMFRGR
110 120 130 140 150
TAVFADQVVV GNASLRLKNV QLTDAGTYTC YIHTSKGKGN ANLEYKTGAF
160 170 180 190 200
SMPEINVDYN ASSESLRCEA PRWFPQPTVA WASQVDQGAN FSEVSNTSFE
210 220 230 240 250
LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TDSEVKRRSQ
260 270 280
LELLNSGPSP CVSSVSAAGW ALLSLSCCLM LR
Length:282
Mass (Da):30,664
Last modified:June 7, 2005 - v1
Checksum:iA487A8DABF27E41C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095842 mRNA. Translation: AAH95842.1.
RefSeqiNP_001019415.1. NM_001024244.1.
UniGeneiRn.160956.

Genome annotation databases

EnsembliENSRNOT00000020566; ENSRNOP00000020566; ENSRNOG00000015279.
GeneIDi295322.
KEGGirno:295322.
UCSCiRGD:1311204. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095842 mRNA. Translation: AAH95842.1.
RefSeqiNP_001019415.1. NM_001024244.1.
UniGeneiRn.160956.

3D structure databases

ProteinModelPortaliQ501W4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020566.

Proteomic databases

PaxDbiQ501W4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020566; ENSRNOP00000020566; ENSRNOG00000015279.
GeneIDi295322.
KEGGirno:295322.
UCSCiRGD:1311204. rat.

Organism-specific databases

CTDi79679.
RGDi1311204. Vtcn1.

Phylogenomic databases

eggNOGiENOG410IKB5. Eukaryota.
ENOG4111T2B. LUCA.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000139645.
HOVERGENiHBG097943.
InParanoidiQ501W4.
KOiK06747.
OMAiVDQGANF.
OrthoDBiEOG091G0IEZ.
PhylomeDBiQ501W4.
TreeFamiTF331083.

Miscellaneous databases

PROiQ501W4.

Gene expression databases

BgeeiENSRNOG00000015279.
GenevisibleiQ501W4. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVTCN1_RAT
AccessioniPrimary (citable) accession number: Q501W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.