UniProtKB - Q501R9 (NBR1_RAT)
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Protein
Next to BRCA1 gene 1 protein
Gene
Nbr1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 213 – 259 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 47 |
GO - Molecular functioni
- mitogen-activated protein kinase binding Source: RGD
- ubiquitin binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- macroautophagy Source: UniProtKB
- negative regulation of osteoblast differentiation Source: RGD
- protein oligomerization Source: UniProtKB
- regulation of bone mineralization Source: RGD
- regulation of stress-activated MAPK cascade Source: RGD
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Next to BRCA1 gene 1 proteinAlternative name(s): Neighbor of BRCA1 gene 1 protein |
Gene namesi | Name:Nbr1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69195. Nbr1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096749 | 1 – 983 | Next to BRCA1 gene 1 proteinAdd BLAST | 983 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 117 | PhosphoserineBy similarity | 1 | |
Modified residuei | 592 | PhosphoserineCombined sources | 1 | |
Modified residuei | 598 | PhosphoserineCombined sources | 1 | |
Modified residuei | 855 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q501R9. |
PRIDEi | Q501R9. |
PTM databases
CarbonylDBi | Q501R9. |
iPTMneti | Q501R9. |
PhosphoSitePlusi | Q501R9. |
Interactioni
Subunit structurei
Homooligomer and heterooligomer. Interacts with RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2 (By similarity). Binds to ubiquitin and ubiquitinated proteins (By similarity). Interacts with SQSTM1, titin/TTN and TRIM55.By similarity1 Publication
GO - Molecular functioni
- mitogen-activated protein kinase binding Source: RGD
- ubiquitin binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 257580. 5 interactors. |
CORUMi | Q501R9. |
STRINGi | 10116.ENSRNOP00000028149. |
Structurei
3D structure databases
ProteinModelPortali | Q501R9. |
SMRi | Q501R9. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 86 | PB1PROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 930 – 974 | UBAPROSITE-ProRule annotationAdd BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 544 – 638 | ATG8 family proteins-bindingBy similarityAdd BLAST | 95 | |
Regioni | 745 – 756 | ATG8 family proteins-bindingBy similarityAdd BLAST | 12 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 709 – 738 | Glu-richAdd BLAST | 30 |
Domaini
The PB1 domain mediates interaction with SQSTM1.By similarity
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 213 – 259 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 47 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4351. Eukaryota. KOG4582. Eukaryota. ENOG4111TKN. LUCA. |
HOGENOMi | HOG000220861. |
HOVERGENi | HBG052578. |
InParanoidi | Q501R9. |
KOi | K17987. |
PhylomeDBi | Q501R9. |
Family and domain databases
CDDi | cd14947. NBR1_like. 1 hit. cd06396. PB1_NBR1. 1 hit. |
Gene3Di | 2.60.40.10. 1 hit. |
InterProi | View protein in InterPro IPR013783. Ig-like_fold. IPR032350. N_BRCA1_central. IPR000270. PB1_dom. IPR034852. PB1_NBR1. IPR015940. UBA. IPR009060. UBA-like_sf. IPR000433. Znf_ZZ. |
Pfami | View protein in Pfam PF16158. N_BRCA1_IG. 1 hit. PF00564. PB1. 1 hit. PF00569. ZZ. 1 hit. |
SMARTi | View protein in SMART SM00666. PB1. 1 hit. SM00291. ZnF_ZZ. 1 hit. |
SUPFAMi | SSF46934. SSF46934. 1 hit. |
PROSITEi | View protein in PROSITE PS51745. PB1. 1 hit. PS50030. UBA. 1 hit. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q501R9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEISINS QGEYEEALKM ANIKQGNQLQ MQVHEGCHVV DEVLPQTVVE
110 120 130 140 150
KQATARTGKK PLAHYSSLVR VLGSDMKTTE EPTAEARSPV PCDTDKPQDK
160 170 180 190 200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPPFS SSPSEVSMPI
210 220 230 240 250
SEEETLFLPE NQFSWHIACS HCQKRIVGVR YQCSLCPSYN ICEDCEAGPY
260 270 280 290 300
SHDTNHILLK FRRPVVISSE PFFYSKYPTP RLPAALEQVR LQKQVDKNFV
310 320 330 340 350
KAEKQRLRAE KKQRKAEVKE LKKQLKLHRK IHLWNSIHGL QSPKSPLGRP
360 370 380 390 400
ESLLQSNTLM LPLQPCAPVM PTLSAAFVDE NLPDGTHLQP GTKFIKHWRM
410 420 430 440 450
KNTGNVKWSA DTKLKFMWGN LTLASTEKKD VLVPCLKAGH IGVVSVEFIA
460 470 480 490 500
PTLEGTYTLH WRLSHKGQQF GPRVWCSIIV DPFPSSESPV NLERDGISSS
510 520 530 540 550
KADDFTCEQE EAFLLAEEEI PLGEVTKQTE GTGSSAPQKT QHAASERELY
560 570 580 590 600
IPSVDLLTAQ DLLSFELLDI NIVQELERVP HNTPVDVTPR MSPLPHDSPL
610 620 630 640 650
IEKPGLGRIQ EESEGAGLKA SPDSTVLTKR KAETPASVEE TEEDLSGTQF
660 670 680 690 700
VCETVIRSLT LDAAPDHNPP CRQRSPQREL QLYSTEEQQP LMLPGFCRKD
710 720 730 740 750
SSLKFALPEE GPHGDEREEI VHIAEEEAIE EEDVQDEEVQ SQSSASSEDY
760 770 780 790 800
IIILPECFDT SRPLGDSMYS SALSQPGLER GAEGEPGIES GQEPAEARER
810 820 830 840 850
LPERESQPKE QSISDILTTS QHLDTVPLVP EVAGLPAALS RSAPCGQYEA
860 870 880 890 900
PRVDSPVTIQ EVLPVPDHVR GEPRGSTGLA NSRQKSCDHS RHHNGSSIAG
910 920 930 940 950
GLVKGALSVA ASAYKALFSG PPVTAQPVIS EDQTAALMAH LFEMGFCDRQ
960 970 980
LNLRLLRKHN HNILQVVTEL LQVNNNDWYS HRY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC095903 mRNA. Translation: AAH95903.1. AF227190 mRNA. Translation: AAF74120.1. AF227191 mRNA. Translation: AAF74121.1. |
RefSeqi | NP_001019936.1. NM_001024765.1. |
UniGenei | Rn.94975. |
Genome annotation databases
GeneIDi | 303554. |
KEGGi | rno:303554. |
UCSCi | RGD:69195. rat. |
Similar proteinsi
Entry informationi
Entry namei | NBR1_RAT | |
Accessioni | Q501R9Primary (citable) accession number: Q501R9 Secondary accession number(s): Q9JHG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | February 28, 2018 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |