Next to BRCA1 gene 1 protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• mitogen-activated protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • 20616007
• ubiquitin binding Source: UniProtKB
• zinc ion binding Source: InterPro

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• macroautophagy Source: UniProtKB
• negative regulation of osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • 20616007
• protein oligomerization Source: UniProtKB
• regulation of bone mineralization Source: RGDInferred from sequence orthologyⁱ
  • 20616007
• regulation of stress-activated MAPK cascade Source: RGDInferred from sequence orthologyⁱ
  • 20616007

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• mitogen-activated protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • 20616007
• ubiquitin binding Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Zinc finger

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD 
        60         70         80         90        100
EENEEISINS QGEYEEALKM ANIKQGNQLQ MQVHEGCHVV DEVLPQTVVE 
       110        120        130        140        150
KQATARTGKK PLAHYSSLVR VLGSDMKTTE EPTAEARSPV PCDTDKPQDK 
       160        170        180        190        200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPPFS SSPSEVSMPI 
       210        220        230        240        250
SEEETLFLPE NQFSWHIACS HCQKRIVGVR YQCSLCPSYN ICEDCEAGPY 
       260        270        280        290        300
SHDTNHILLK FRRPVVISSE PFFYSKYPTP RLPAALEQVR LQKQVDKNFV 
       310        320        330        340        350
KAEKQRLRAE KKQRKAEVKE LKKQLKLHRK IHLWNSIHGL QSPKSPLGRP 
       360        370        380        390        400
ESLLQSNTLM LPLQPCAPVM PTLSAAFVDE NLPDGTHLQP GTKFIKHWRM 
       410        420        430        440        450
KNTGNVKWSA DTKLKFMWGN LTLASTEKKD VLVPCLKAGH IGVVSVEFIA 
       460        470        480        490        500
PTLEGTYTLH WRLSHKGQQF GPRVWCSIIV DPFPSSESPV NLERDGISSS 
       510        520        530        540        550
KADDFTCEQE EAFLLAEEEI PLGEVTKQTE GTGSSAPQKT QHAASERELY 
       560        570        580        590        600
IPSVDLLTAQ DLLSFELLDI NIVQELERVP HNTPVDVTPR MSPLPHDSPL 
       610        620        630        640        650
IEKPGLGRIQ EESEGAGLKA SPDSTVLTKR KAETPASVEE TEEDLSGTQF 
       660        670        680        690        700
VCETVIRSLT LDAAPDHNPP CRQRSPQREL QLYSTEEQQP LMLPGFCRKD 
       710        720        730        740        750
SSLKFALPEE GPHGDEREEI VHIAEEEAIE EEDVQDEEVQ SQSSASSEDY 
       760        770        780        790        800
IIILPECFDT SRPLGDSMYS SALSQPGLER GAEGEPGIES GQEPAEARER 
       810        820        830        840        850
LPERESQPKE QSISDILTTS QHLDTVPLVP EVAGLPAALS RSAPCGQYEA 
       860        870        880        890        900
PRVDSPVTIQ EVLPVPDHVR GEPRGSTGLA NSRQKSCDHS RHHNGSSIAG 
       910        920        930        940        950
GLVKGALSVA ASAYKALFSG PPVTAQPVIS EDQTAALMAH LFEMGFCDRQ 
       960        970        980 
LNLRLLRKHN HNILQVVTEL LQVNNNDWYS HRY                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ