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Protein

Next to BRCA1 gene 1 protein

Gene

Nbr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri213 – 25947ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Next to BRCA1 gene 1 protein
Alternative name(s):
Neighbor of BRCA1 gene 1 protein
Gene namesi
Name:Nbr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69195. Nbr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 983983Next to BRCA1 gene 1 proteinPRO_0000096749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei592 – 5921PhosphoserineCombined sources
Modified residuei598 – 5981PhosphoserineCombined sources
Modified residuei855 – 8551PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ501R9.
PRIDEiQ501R9.

PTM databases

iPTMnetiQ501R9.
PhosphoSiteiQ501R9.

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2 (By similarity). Binds to ubiquitin and ubiquitinated proteins (By similarity). Interacts with SQSTM1, titin/TTN and TRIM55.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi257580. 5 interactions.
STRINGi10116.ENSRNOP00000028149.

Structurei

3D structure databases

ProteinModelPortaliQ501R9.
SMRiQ501R9. Positions 1-86, 930-974.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8683PB1PROSITE-ProRule annotationAdd
BLAST
Domaini930 – 97445UBAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni544 – 63895ATG8 family proteins-bindingBy similarityAdd
BLAST
Regioni745 – 75612ATG8 family proteins-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi709 – 73830Glu-richAdd
BLAST

Domaini

The PB1 domain mediates interaction with SQSTM1.By similarity

Sequence similaritiesi

Contains 1 PB1 domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri213 – 25947ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4351. Eukaryota.
KOG4582. Eukaryota.
ENOG4111TKN. LUCA.
HOGENOMiHOG000220861.
HOVERGENiHBG052578.
InParanoidiQ501R9.
KOiK17987.
PhylomeDBiQ501R9.

Family and domain databases

InterProiIPR032350. N_BRCA1_central.
IPR000270. PB1_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF16158. N_BRCA1_IG. 1 hit.
PF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q501R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEISINS QGEYEEALKM ANIKQGNQLQ MQVHEGCHVV DEVLPQTVVE
110 120 130 140 150
KQATARTGKK PLAHYSSLVR VLGSDMKTTE EPTAEARSPV PCDTDKPQDK
160 170 180 190 200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPPFS SSPSEVSMPI
210 220 230 240 250
SEEETLFLPE NQFSWHIACS HCQKRIVGVR YQCSLCPSYN ICEDCEAGPY
260 270 280 290 300
SHDTNHILLK FRRPVVISSE PFFYSKYPTP RLPAALEQVR LQKQVDKNFV
310 320 330 340 350
KAEKQRLRAE KKQRKAEVKE LKKQLKLHRK IHLWNSIHGL QSPKSPLGRP
360 370 380 390 400
ESLLQSNTLM LPLQPCAPVM PTLSAAFVDE NLPDGTHLQP GTKFIKHWRM
410 420 430 440 450
KNTGNVKWSA DTKLKFMWGN LTLASTEKKD VLVPCLKAGH IGVVSVEFIA
460 470 480 490 500
PTLEGTYTLH WRLSHKGQQF GPRVWCSIIV DPFPSSESPV NLERDGISSS
510 520 530 540 550
KADDFTCEQE EAFLLAEEEI PLGEVTKQTE GTGSSAPQKT QHAASERELY
560 570 580 590 600
IPSVDLLTAQ DLLSFELLDI NIVQELERVP HNTPVDVTPR MSPLPHDSPL
610 620 630 640 650
IEKPGLGRIQ EESEGAGLKA SPDSTVLTKR KAETPASVEE TEEDLSGTQF
660 670 680 690 700
VCETVIRSLT LDAAPDHNPP CRQRSPQREL QLYSTEEQQP LMLPGFCRKD
710 720 730 740 750
SSLKFALPEE GPHGDEREEI VHIAEEEAIE EEDVQDEEVQ SQSSASSEDY
760 770 780 790 800
IIILPECFDT SRPLGDSMYS SALSQPGLER GAEGEPGIES GQEPAEARER
810 820 830 840 850
LPERESQPKE QSISDILTTS QHLDTVPLVP EVAGLPAALS RSAPCGQYEA
860 870 880 890 900
PRVDSPVTIQ EVLPVPDHVR GEPRGSTGLA NSRQKSCDHS RHHNGSSIAG
910 920 930 940 950
GLVKGALSVA ASAYKALFSG PPVTAQPVIS EDQTAALMAH LFEMGFCDRQ
960 970 980
LNLRLLRKHN HNILQVVTEL LQVNNNDWYS HRY
Length:983
Mass (Da):109,829
Last modified:June 7, 2005 - v1
Checksum:i4A80880D9EDDE729
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095903 mRNA. Translation: AAH95903.1.
AF227190 mRNA. Translation: AAF74120.1.
AF227191 mRNA. Translation: AAF74121.1.
RefSeqiNP_001019936.1. NM_001024765.1.
UniGeneiRn.94975.

Genome annotation databases

GeneIDi303554.
KEGGirno:303554.
UCSCiRGD:69195. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095903 mRNA. Translation: AAH95903.1.
AF227190 mRNA. Translation: AAF74120.1.
AF227191 mRNA. Translation: AAF74121.1.
RefSeqiNP_001019936.1. NM_001024765.1.
UniGeneiRn.94975.

3D structure databases

ProteinModelPortaliQ501R9.
SMRiQ501R9. Positions 1-86, 930-974.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi257580. 5 interactions.
STRINGi10116.ENSRNOP00000028149.

PTM databases

iPTMnetiQ501R9.
PhosphoSiteiQ501R9.

Proteomic databases

PaxDbiQ501R9.
PRIDEiQ501R9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi303554.
KEGGirno:303554.
UCSCiRGD:69195. rat.

Organism-specific databases

CTDi4077.
RGDi69195. Nbr1.

Phylogenomic databases

eggNOGiKOG4351. Eukaryota.
KOG4582. Eukaryota.
ENOG4111TKN. LUCA.
HOGENOMiHOG000220861.
HOVERGENiHBG052578.
InParanoidiQ501R9.
KOiK17987.
PhylomeDBiQ501R9.

Miscellaneous databases

NextBioi651584.
PROiQ501R9.

Family and domain databases

InterProiIPR032350. N_BRCA1_central.
IPR000270. PB1_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF16158. N_BRCA1_IG. 1 hit.
PF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes."
    Dimitrov S., Brennerova M., Forejt J.
    Gene 262:89-98(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-43.
    Strain: SHR.
    Tissue: Testis.
  3. Cited for: INTERACTION WITH SQSTM1; TTN AND TRIM55, SUBCELLULAR LOCATION.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-592; SER-598 AND SER-855, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNBR1_RAT
AccessioniPrimary (citable) accession number: Q501R9
Secondary accession number(s): Q9JHG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: June 7, 2005
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.