Nbr1

Functionⁱ

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	213 – 259	ZZ-typePROSITE-ProRule annotationAdd BLAST		47

GO - Molecular functionⁱ

ubiquitin binding Source: UniProtKB
zinc ion binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

macroautophagy Source: UniProtKB
protein oligomerization Source: UniProtKB

Complete GO annotation...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Next to BRCA1 gene 1 protein Alternative name(s): Neighbor of BRCA1 gene 1 protein
Gene namesⁱ	Name:Nbr1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	69195. Nbr1.

RGDⁱ

69195. Nbr1.

Subcellular locationⁱ

Cytoplasm
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q14596 (NBR1_HUMAN)
Cytoplasmic vesicle › autophagosome
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q14596 (NBR1_HUMAN)
Lysosome
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q14596 (NBR1_HUMAN)
Cytoplasm › myofibril › sarcomere › M line
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "The kinase domain of titin controls muscle gene expression and protein turnover."
  Lange S., Xiang F., Yakovenko A., Vihola A., Hackman P., Rostkova E., Kristensen J., Brandmeier B., Franzen G., Hedberg B., Gunnarsson L.G., Hughes S.M., Marchand S., Sejersen T., Richard I., Edstroem L., Ehler E., Udd B., Gautel M.
  Science 308:1599-1603(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: INTERACTION WITH SQSTM1; TTN AND TRIM55, SUBCELLULAR LOCATION.

Note:

In cardiac muscles localizes to the sarcomeric M line (PubMed:15802564). Is targeted to lysosomes for degradation (By similarity).By similarity1 Publication

GO - Cellular componentⁱ

autophagosome Source: GO_Central
cytosol Source: UniProtKB
late endosome Source: UniProtKB
lysosome Source: UniProtKB-SubCell
M band Source: UniProtKB-SubCell
pre-autophagosomal structure Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Lysosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096749	1 – 983	Next to BRCA1 gene 1 proteinAdd BLAST		983

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	117	PhosphoserineBy similarity	1
Modified residueⁱ	592	PhosphoserineCombined sources	1
Modified residueⁱ	598	PhosphoserineCombined sources	1
Modified residueⁱ	855	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q501R9.
PRIDEⁱ	Q501R9.

PTM databases

iPTMnetⁱ	Q501R9.
PhosphoSitePlusⁱ	Q501R9.

Interactionⁱ

Subunit structureⁱ

Homooligomer and heterooligomer. Interacts with RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2 (By similarity). Binds to ubiquitin and ubiquitinated proteins (By similarity). Interacts with SQSTM1, titin/TTN and TRIM55.By similarity1 Publication

GO - Molecular functionⁱ

ubiquitin binding Source: UniProtKB

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	257580. 5 interactors.
STRINGⁱ	10116.ENSRNOP00000028149.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q501R9.
SMRⁱ	Q501R9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 86	PB1PROSITE-ProRule annotationAdd BLAST		83
Domainⁱ	930 – 974	UBAPROSITE-ProRule annotationAdd BLAST		45

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	544 – 638	ATG8 family proteins-bindingBy similarityAdd BLAST		95
Regionⁱ	745 – 756	ATG8 family proteins-bindingBy similarityAdd BLAST		12

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	709 – 738	Glu-richAdd BLAST		30

Domainⁱ

The PB1 domain mediates interaction with SQSTM1.By similarity

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	213 – 259	ZZ-typePROSITE-ProRule annotationAdd BLAST		47

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4351. Eukaryota. KOG4582. Eukaryota. ENOG4111TKN. LUCA.
HOGENOMⁱ	HOG000220861.
HOVERGENⁱ	HBG052578.
InParanoidⁱ	Q501R9.
KEGG Orthology (KO) More...KOⁱ	K17987.
PhylomeDBⁱ	Q501R9.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14947. NBR1_like. 1 hit. cd06396. PB1_NBR1. 1 hit.
InterProⁱ	View protein in InterPro IPR032350. N_BRCA1_central. IPR033513. NBR1. IPR000270. PB1_dom. IPR034852. PB1_NBR1. IPR015940. UBA. IPR009060. UBA-like. IPR000433. Znf_ZZ.
PANTHERⁱ	PTHR20930:SF6. PTHR20930:SF6. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16158. N_BRCA1_IG. 1 hit. PF00564. PB1. 1 hit. PF00569. ZZ. 1 hit.
SMARTⁱ	View protein in SMART SM00666. PB1. 1 hit. SM00291. ZnF_ZZ. 1 hit.
SUPFAMⁱ	SSF46934. SSF46934. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51745. PB1. 1 hit. PS50030. UBA. 1 hit. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q501R9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD 
        60         70         80         90        100
EENEEISINS QGEYEEALKM ANIKQGNQLQ MQVHEGCHVV DEVLPQTVVE 
       110        120        130        140        150
KQATARTGKK PLAHYSSLVR VLGSDMKTTE EPTAEARSPV PCDTDKPQDK 
       160        170        180        190        200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPPFS SSPSEVSMPI 
       210        220        230        240        250
SEEETLFLPE NQFSWHIACS HCQKRIVGVR YQCSLCPSYN ICEDCEAGPY 
       260        270        280        290        300
SHDTNHILLK FRRPVVISSE PFFYSKYPTP RLPAALEQVR LQKQVDKNFV 
       310        320        330        340        350
KAEKQRLRAE KKQRKAEVKE LKKQLKLHRK IHLWNSIHGL QSPKSPLGRP 
       360        370        380        390        400
ESLLQSNTLM LPLQPCAPVM PTLSAAFVDE NLPDGTHLQP GTKFIKHWRM 
       410        420        430        440        450
KNTGNVKWSA DTKLKFMWGN LTLASTEKKD VLVPCLKAGH IGVVSVEFIA 
       460        470        480        490        500
PTLEGTYTLH WRLSHKGQQF GPRVWCSIIV DPFPSSESPV NLERDGISSS 
       510        520        530        540        550
KADDFTCEQE EAFLLAEEEI PLGEVTKQTE GTGSSAPQKT QHAASERELY 
       560        570        580        590        600
IPSVDLLTAQ DLLSFELLDI NIVQELERVP HNTPVDVTPR MSPLPHDSPL 
       610        620        630        640        650
IEKPGLGRIQ EESEGAGLKA SPDSTVLTKR KAETPASVEE TEEDLSGTQF 
       660        670        680        690        700
VCETVIRSLT LDAAPDHNPP CRQRSPQREL QLYSTEEQQP LMLPGFCRKD 
       710        720        730        740        750
SSLKFALPEE GPHGDEREEI VHIAEEEAIE EEDVQDEEVQ SQSSASSEDY 
       760        770        780        790        800
IIILPECFDT SRPLGDSMYS SALSQPGLER GAEGEPGIES GQEPAEARER 
       810        820        830        840        850
LPERESQPKE QSISDILTTS QHLDTVPLVP EVAGLPAALS RSAPCGQYEA 
       860        870        880        890        900
PRVDSPVTIQ EVLPVPDHVR GEPRGSTGLA NSRQKSCDHS RHHNGSSIAG 
       910        920        930        940        950
GLVKGALSVA ASAYKALFSG PPVTAQPVIS EDQTAALMAH LFEMGFCDRQ 
       960        970        980 
LNLRLLRKHN HNILQVVTEL LQVNNNDWYS HRY

Length:983

Mass (Da):109,829

Last modified:June 7, 2005 - v1

Checksum:ⁱ4A80880D9EDDE729

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC095903 mRNA. Translation: AAH95903.1. AF227190 mRNA. Translation: AAF74120.1. AF227191 mRNA. Translation: AAF74121.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001019936.1. NM_001024765.1.
UniGeneⁱ	Rn.94975.

Genome annotation databases

GeneIDⁱ	303554.
KEGGⁱ	rno:303554.
UCSC genome browser More...UCSCⁱ	RGD:69195. rat.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC095903 mRNA. Translation: AAH95903.1. AF227190 mRNA. Translation: AAF74120.1. AF227191 mRNA. Translation: AAF74121.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001019936.1. NM_001024765.1.
UniGeneⁱ	Rn.94975.

3D structure databases

ProteinModelPortalⁱ	Q501R9.
SMRⁱ	Q501R9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	257580. 5 interactors.
STRINGⁱ	10116.ENSRNOP00000028149.

PTM databases

iPTMnetⁱ	Q501R9.
PhosphoSitePlusⁱ	Q501R9.

Proteomic databases

PaxDbⁱ	Q501R9.
PRIDEⁱ	Q501R9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	303554.
KEGGⁱ	rno:303554.
UCSC genome browser More...UCSCⁱ	RGD:69195. rat.

Organism-specific databases

CTDⁱ	4077.
Rat genome database More...RGDⁱ	69195. Nbr1.

Phylogenomic databases

eggNOGⁱ	KOG4351. Eukaryota. KOG4582. Eukaryota. ENOG4111TKN. LUCA.
HOGENOMⁱ	HOG000220861.
HOVERGENⁱ	HBG052578.
InParanoidⁱ	Q501R9.
KEGG Orthology (KO) More...KOⁱ	K17987.
PhylomeDBⁱ	Q501R9.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q501R9.

PROⁱ

PR:Q501R9.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14947. NBR1_like. 1 hit. cd06396. PB1_NBR1. 1 hit.
InterProⁱ	View protein in InterPro IPR032350. N_BRCA1_central. IPR033513. NBR1. IPR000270. PB1_dom. IPR034852. PB1_NBR1. IPR015940. UBA. IPR009060. UBA-like. IPR000433. Znf_ZZ.
PANTHERⁱ	PTHR20930:SF6. PTHR20930:SF6. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16158. N_BRCA1_IG. 1 hit. PF00564. PB1. 1 hit. PF00569. ZZ. 1 hit.
SMARTⁱ	View protein in SMART SM00666. PB1. 1 hit. SM00291. ZnF_ZZ. 1 hit.
SUPFAMⁱ	SSF46934. SSF46934. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51745. PB1. 1 hit. PS50030. UBA. 1 hit. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NBR1_RAT
Accessionⁱ	Q501R9Primary (citable) accession number: Q501R9 Secondary accession number(s): Q9JHG4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
	Last sequence update:	June 7, 2005
	Last modified:	June 7, 2017
	This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q501R9 (NBR1_RAT)

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Next to BRCA1 gene 1 protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Zinc finger

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ