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Q501R2

- Q501R2_XENTR

UniProt

Q501R2 - Q501R2_XENTR

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Protein
Submitted name:

Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)

Gene

ptgs2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. peroxidase activity Source: InterPro
  3. prostaglandin-endoperoxide synthase activity Source: InterPro

GO - Biological processi

  1. cyclooxygenase pathway Source: InterPro
  2. inflammatory response Source: InterPro
  3. regulation of blood pressure Source: InterPro
  4. response to oxidative stress Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_195853. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_209519. Synthesis of 15-eicosatetraenoic acid derivatives.

Protein family/group databases

PeroxiBasei4266. XtPGHS02.

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ptgs2Imported
Synonyms:MGC97821Imported
ORF Names:TGas066j02.1-001Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-482133. ptgs2.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037831.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG39991.
GeneTreeiENSGT00390000010743.
HOGENOMiHOG000013149.
HOVERGENiHBG000366.
KOiK11987.
OMAiRRNIANN.
OrthoDBiEOG7RFTHC.
TreeFamiTF329675.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q501R2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVLPAAVFL SLLVFSQAAN PCCSNPCQNR GVCMTVGHDR YECDCTRTGF
60 70 80 90 100
YGENCTKPEF LSWLRLKLKP APNTVHYILT HFKGLWNIVN NISFLRDAIM
110 120 130 140 150
RYVLTSRSHL IDSPPTYNSH YGYKSWEAFS NLSYYTRTLP PVERDCPTPM
160 170 180 190 200
GVKGMKELPS AKLVVEKFLM RRKFIPDPQG SNVMFAFFAQ HFTHQFFRTD
210 220 230 240 250
MAKGAAFTKA LGHGVDLNHI YGESLERQHK LRLMKGGKLK YQMISGEMYP
260 270 280 290 300
PTVKTTGVDM VYPPHIPDHL QFAVGQEVFG LVPGLMMYST IWLREHNRVC
310 320 330 340 350
DILSNEHPEW DDERIFQTAR LILIGETIKI VIEDYVQHLS GYHFKLKFDP
360 370 380 390 400
ELLFNQKFQY QNRISAEFNT LYHWHPLLPD TFAISEKEYS YPQFLYNNSV
410 420 430 440 450
MLNHGLTEMV ESFSRQTAGR VAGGRNFPAA ITRVAVASIE HSREMRYQSL
460 470 480 490 500
NEYRKRFMLK PFESFEELTG EKEMSAELEK LYGDIDAMEF YPGLLVEQPR
510 520 530 540 550
PGAIFGETMV EIGAPFSLKG LMGNPICSPE YWKPSTFGGS VGFDIVNSAS
560 570 580 590 600
LQKLICNNVR DCPYTAFHVL KSKPSEKDFI NASSDSTLEN VKPSLILKEH

ASEL
Length:604
Mass (Da):69,100
Last modified:June 7, 2005 - v1
Checksum:i6333B374EA926B0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01026272 Genomic DNA. No translation available.
BC095912 mRNA. Translation: AAH95912.1.
CR942339 mRNA. Translation: CAJ83938.1.
RefSeqiNP_001025697.1. NM_001030526.1.
UniGeneiStr.15770.

Genome annotation databases

EnsembliENSXETT00000037831; ENSXETP00000037831; ENSXETG00000017378.
GeneIDi595089.
KEGGixtr:595089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01026272 Genomic DNA. No translation available.
BC095912 mRNA. Translation: AAH95912.1 .
CR942339 mRNA. Translation: CAJ83938.1 .
RefSeqi NP_001025697.1. NM_001030526.1.
UniGenei Str.15770.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000037831.

Protein family/group databases

PeroxiBasei 4266. XtPGHS02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000037831 ; ENSXETP00000037831 ; ENSXETG00000017378 .
GeneIDi 595089.
KEGGi xtr:595089.

Organism-specific databases

CTDi 5743.
Xenbasei XB-GENE-482133. ptgs2.

Phylogenomic databases

eggNOGi NOG39991.
GeneTreei ENSGT00390000010743.
HOGENOMi HOG000013149.
HOVERGENi HBG000366.
KOi K11987.
OMAi RRNIANN.
OrthoDBi EOG7RFTHC.
TreeFami TF329675.

Enzyme and pathway databases

Reactomei REACT_195853. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_209519. Synthesis of 15-eicosatetraenoic acid derivatives.

Family and domain databases

Gene3Di 1.10.640.10. 1 hit.
InterProi IPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view ]
PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
Pfami PF03098. An_peroxidase. 2 hits.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ501R2_XENTR
AccessioniPrimary (citable) accession number: Q501R2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3