Q501F9 (P2C67_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable protein phosphatase 2C 67
Short name=AtPP2C67
EC=3.1.3.16

Gene names

Ordered Locus Names:	At5g02760
ORF Names:	F9G14.70

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity.
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.
Sequence caution	The sequence CAB86030.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Probable protein phosphatase 2C 67		PRO_0000367988
Regions
	Domain	72 – 316	245	PP2C-like
Sites
	Metal binding	77	1	Manganese 1 By similarity
	Metal binding	77	1	Manganese 2 By similarity
	Metal binding	78	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	276	1	Manganese 2 By similarity
	Metal binding	335	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q501F9 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: 9F21EC0115FD62FD	FASTA	370	41,334
	10 20 30 40 50 60 MVKPCWRIGA GMERSKINPT KVDGLTWYKD LGLHTFGEFS MAMIQANSVM EDQCQIESGP 70 80 90 100 110 120 LTFNNPTVQG TFVGVYDGHG GPEASRFIAD NIFPKLKKFA SEGREISEQV ISKAFAETDK 130 140 150 160 170 180 DFLKTVTKQW PTNPQMASVG SCCLAGVICN GLVYIANTGD SRAVLGRSER GGVRAVQLSV 190 200 210 220 230 240 EHNANLESAR QELWSLHPND PTILVMKHRL WRVKGVIQVT RSIGDAYLKR AEFNREPLLP 250 260 270 280 290 300 KFRLPEHFTK PILSADPSVT ITRLSPQDEF IILASDGLWE HLSNQEAVDI VHNSPRQGIA 310 320 330 340 350 360 RRLLKAALKE AAKKREMRYS DLTEIHPGVR RHFHDDITVI VVYLNPHPVK TNSWASPLSI 370 RGGYPMHSTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana." Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F. Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Arabidopsis ORF clones." Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis." Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y. BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL162973 Genomic DNA. Translation: CAB86030.1. Sequence problems. CP002688 Genomic DNA. Translation: AED90514.1. BT022008 mRNA. Translation: AAY25420.1. BT023482 mRNA. Translation: AAY57321.1.
IPI	IPI00547923.
PIR	T48297.
RefSeq	NP_195896.2. NM_120354.3.
UniGene	At.23648. At.69718.
3D structure databases
ProteinModelPortal	Q501F9.
SMR	Q501F9. Positions 44-349.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT5G02760.1-P.
Proteomic databases
PaxDb	Q501F9.
PRIDE	Q501F9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT5G02760.1; AT5G02760.1; AT5G02760.
GeneID	831234.
KEGG	ath:AT5G02760.
Organism-specific databases
TAIR	At5g02760.
Phylogenomic databases
eggNOG	COG0631.
HOGENOM	HOG000238703.
InParanoid	Q501F9.
OMA	MVKPCWR.
PhylomeDB	Q501F9.
ProtClustDB	CLSN2918014.
Gene expression databases
Genevestigator	Q501F9.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. IPR000222. PP2C_Mn2_Asp60_BS. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
PROSITE	PS01032. PP2C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P2C67_ARATH

Accession

Primary (citable) accession number: Q501F9
Secondary accession number(s): Q9LZ09

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program