Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q50192

- SYL_MYCLE

UniProt

Q50192 - SYL_MYCLE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei744 – 7441ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:ML0032
ORF Names:MLB1770.20, MLCB628.03
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0032.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 972972Leucine--tRNA ligasePRO_0000152046Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0032.

Structurei

3D structure databases

ProteinModelPortaliQ50192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi78 – 8912"HIGH" regionAdd
BLAST
Motifi741 – 7455"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50192-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELPTTVPG YNSAVAQTDS DAMRYRYTAE LAGRIESTWQ DNWARLQTFN
60 70 80 90 100
VPNPVGSLAP PDGSVVPADK LFVQDMFPYP SGDGLHVGHP LGYIATDVYA
110 120 130 140 150
RYFRMTGHNV LHAMGFDAFG LPAEQYAMQT GTHPRILTEA NVVNFRHQLG
160 170 180 190 200
RLGLGHDSRR TFSTTDVEFY KWTQWIFLQI YNAWFDVAAN KARPIAELIA
210 220 230 240 250
EFDSGERRLV DGRDWATLSA GERADVIDNC RLVYRADSMV NWCPGLGTVL
260 270 280 290 300
ANEEVTADGR SDRGNFPVFR KRLRQWMMRI TAYADRLLDD LDLLDWPEQV
310 320 330 340 350
KTMQRNWIGR SSGATVLFSA ILSRSDAATT EVDVEVFTTR PDTMFGVTYL
360 370 380 390 400
VLAPEHNLVD ELVATVWPDR TDPRWTYGAA TPGAAVAAYR RAIVAKSDLD
410 420 430 440 450
RQESKEKTGV FLGRYATNPA TGKPVPIFVA DYVLVGYGTG AVMAVPGHDP
460 470 480 490 500
RDWDFAHKFH LPIVEVIAGS DISEAAYVGD GVLVNSGYLD GMDVATAQEA
510 520 530 540 550
ITARLESEGR GHARIEFKLR DWLFARQRYW GEPFPIIYDS DGRPHALDEA
560 570 580 590 600
ALPVELPDVP YYSPVLFDPD DADSEPSPPL AKATEWVHVE LDLGDGLKPY
610 620 630 640 650
SRDTNVMPQW AGSSWYELRY TDPHNSERLC AKENEAYWMG PRPTEHGIDD
660 670 680 690 700
PGGVDLYVGG AEHAVLHLLY ARFWHKVLYD LGHVSSREPY RRLINQGYIQ
710 720 730 740 750
AFAYTDAHGS YVPANQVFQR GDGFFCPGPD GEIEVFQEFG KIGKSLKNSV
760 770 780 790 800
SPDEICDEYG ADTLRVYEMS MGPLEASRPW ATKDVVGAYR FLQRVWRLVV
810 820 830 840 850
DERTGETRVV DTAGELDTYT LRTLHRTIAG VSQDYAALRN NTATAKLIEY
860 870 880 890 900
TNHLTKEHRG SVPRVAVEPL VLMLAPLAPH LAEELWLRLG HTTSLANGPF
910 920 930 940 950
PQADPAYLVD DTVEYPVQVN GKIRGRIVVA ADADYDTLKT VALADDKVQQ
960 970
FLAGATPRKV IVVAGRLISL VI
Length:972
Mass (Da):108,408
Last modified:January 1, 1998 - v2
Checksum:i65286839DA51AFAE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti659 – 66810GGAEHAVLHL → AEPNMRCYIC in CAA94727. (PubMed:11234002)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14967 Genomic DNA. Translation: CAA75192.1.
Z70722 Genomic DNA. Translation: CAA94727.1.
AL583917 Genomic DNA. Translation: CAC29540.1.
PIRiT10023.
RefSeqiNP_301156.1. NC_002677.1.
WP_010907481.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29540; CAC29540; CAC29540.
GeneIDi908194.
KEGGimle:ML0032.
PATRICi18050166. VBIMycLep78757_0040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14967 Genomic DNA. Translation: CAA75192.1 .
Z70722 Genomic DNA. Translation: CAA94727.1 .
AL583917 Genomic DNA. Translation: CAC29540.1 .
PIRi T10023.
RefSeqi NP_301156.1. NC_002677.1.
WP_010907481.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q50192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0032.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29540 ; CAC29540 ; CAC29540 .
GeneIDi 908194.
KEGGi mle:ML0032.
PATRICi 18050166. VBIMycLep78757_0040.

Organism-specific databases

Lepromai ML0032.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiSYL_MYCLE
AccessioniPrimary (citable) accession number: Q50192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3