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Q50192

- SYL_MYCLE

UniProt

Q50192 - SYL_MYCLE

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei744 – 7441ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:ML0032
    ORF Names:MLB1770.20, MLCB628.03
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0032.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 972972Leucine--tRNA ligasePRO_0000152046Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0032.

    Structurei

    3D structure databases

    ProteinModelPortaliQ50192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi78 – 8912"HIGH" regionAdd
    BLAST
    Motifi741 – 7455"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q50192-1 [UniParc]FASTAAdd to Basket

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    MTELPTTVPG YNSAVAQTDS DAMRYRYTAE LAGRIESTWQ DNWARLQTFN    50
    VPNPVGSLAP PDGSVVPADK LFVQDMFPYP SGDGLHVGHP LGYIATDVYA 100
    RYFRMTGHNV LHAMGFDAFG LPAEQYAMQT GTHPRILTEA NVVNFRHQLG 150
    RLGLGHDSRR TFSTTDVEFY KWTQWIFLQI YNAWFDVAAN KARPIAELIA 200
    EFDSGERRLV DGRDWATLSA GERADVIDNC RLVYRADSMV NWCPGLGTVL 250
    ANEEVTADGR SDRGNFPVFR KRLRQWMMRI TAYADRLLDD LDLLDWPEQV 300
    KTMQRNWIGR SSGATVLFSA ILSRSDAATT EVDVEVFTTR PDTMFGVTYL 350
    VLAPEHNLVD ELVATVWPDR TDPRWTYGAA TPGAAVAAYR RAIVAKSDLD 400
    RQESKEKTGV FLGRYATNPA TGKPVPIFVA DYVLVGYGTG AVMAVPGHDP 450
    RDWDFAHKFH LPIVEVIAGS DISEAAYVGD GVLVNSGYLD GMDVATAQEA 500
    ITARLESEGR GHARIEFKLR DWLFARQRYW GEPFPIIYDS DGRPHALDEA 550
    ALPVELPDVP YYSPVLFDPD DADSEPSPPL AKATEWVHVE LDLGDGLKPY 600
    SRDTNVMPQW AGSSWYELRY TDPHNSERLC AKENEAYWMG PRPTEHGIDD 650
    PGGVDLYVGG AEHAVLHLLY ARFWHKVLYD LGHVSSREPY RRLINQGYIQ 700
    AFAYTDAHGS YVPANQVFQR GDGFFCPGPD GEIEVFQEFG KIGKSLKNSV 750
    SPDEICDEYG ADTLRVYEMS MGPLEASRPW ATKDVVGAYR FLQRVWRLVV 800
    DERTGETRVV DTAGELDTYT LRTLHRTIAG VSQDYAALRN NTATAKLIEY 850
    TNHLTKEHRG SVPRVAVEPL VLMLAPLAPH LAEELWLRLG HTTSLANGPF 900
    PQADPAYLVD DTVEYPVQVN GKIRGRIVVA ADADYDTLKT VALADDKVQQ 950
    FLAGATPRKV IVVAGRLISL VI 972
    Length:972
    Mass (Da):108,408
    Last modified:January 1, 1998 - v2
    Checksum:i65286839DA51AFAE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti659 – 66810GGAEHAVLHL → AEPNMRCYIC in CAA94727. (PubMed:11234002)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14967 Genomic DNA. Translation: CAA75192.1.
    Z70722 Genomic DNA. Translation: CAA94727.1.
    AL583917 Genomic DNA. Translation: CAC29540.1.
    PIRiT10023.
    RefSeqiNP_301156.1. NC_002677.1.
    WP_010907481.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29540; CAC29540; CAC29540.
    GeneIDi908194.
    KEGGimle:ML0032.
    PATRICi18050166. VBIMycLep78757_0040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14967 Genomic DNA. Translation: CAA75192.1 .
    Z70722 Genomic DNA. Translation: CAA94727.1 .
    AL583917 Genomic DNA. Translation: CAC29540.1 .
    PIRi T10023.
    RefSeqi NP_301156.1. NC_002677.1.
    WP_010907481.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q50192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29540 ; CAC29540 ; CAC29540 .
    GeneIDi 908194.
    KEGGi mle:ML0032.
    PATRICi 18050166. VBIMycLep78757_0040.

    Organism-specific databases

    Lepromai ML0032.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiSYL_MYCLE
    AccessioniPrimary (citable) accession number: Q50192
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3