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Q50192

- SYL_MYCLE

UniProt

Q50192 - SYL_MYCLE

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Protein

Leucine--tRNA ligase

Gene
leuS, ML0032, MLB1770.20, MLCB628.03
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei744 – 7441ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:ML0032
ORF Names:MLB1770.20, MLCB628.03
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0032.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 972972Leucine--tRNA ligaseUniRule annotationPRO_0000152046Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0032.

Structurei

3D structure databases

ProteinModelPortaliQ50192.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi78 – 8912"HIGH" regionUniRule annotationAdd
BLAST
Motifi741 – 7455"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50192-1 [UniParc]FASTAAdd to Basket

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MTELPTTVPG YNSAVAQTDS DAMRYRYTAE LAGRIESTWQ DNWARLQTFN    50
VPNPVGSLAP PDGSVVPADK LFVQDMFPYP SGDGLHVGHP LGYIATDVYA 100
RYFRMTGHNV LHAMGFDAFG LPAEQYAMQT GTHPRILTEA NVVNFRHQLG 150
RLGLGHDSRR TFSTTDVEFY KWTQWIFLQI YNAWFDVAAN KARPIAELIA 200
EFDSGERRLV DGRDWATLSA GERADVIDNC RLVYRADSMV NWCPGLGTVL 250
ANEEVTADGR SDRGNFPVFR KRLRQWMMRI TAYADRLLDD LDLLDWPEQV 300
KTMQRNWIGR SSGATVLFSA ILSRSDAATT EVDVEVFTTR PDTMFGVTYL 350
VLAPEHNLVD ELVATVWPDR TDPRWTYGAA TPGAAVAAYR RAIVAKSDLD 400
RQESKEKTGV FLGRYATNPA TGKPVPIFVA DYVLVGYGTG AVMAVPGHDP 450
RDWDFAHKFH LPIVEVIAGS DISEAAYVGD GVLVNSGYLD GMDVATAQEA 500
ITARLESEGR GHARIEFKLR DWLFARQRYW GEPFPIIYDS DGRPHALDEA 550
ALPVELPDVP YYSPVLFDPD DADSEPSPPL AKATEWVHVE LDLGDGLKPY 600
SRDTNVMPQW AGSSWYELRY TDPHNSERLC AKENEAYWMG PRPTEHGIDD 650
PGGVDLYVGG AEHAVLHLLY ARFWHKVLYD LGHVSSREPY RRLINQGYIQ 700
AFAYTDAHGS YVPANQVFQR GDGFFCPGPD GEIEVFQEFG KIGKSLKNSV 750
SPDEICDEYG ADTLRVYEMS MGPLEASRPW ATKDVVGAYR FLQRVWRLVV 800
DERTGETRVV DTAGELDTYT LRTLHRTIAG VSQDYAALRN NTATAKLIEY 850
TNHLTKEHRG SVPRVAVEPL VLMLAPLAPH LAEELWLRLG HTTSLANGPF 900
PQADPAYLVD DTVEYPVQVN GKIRGRIVVA ADADYDTLKT VALADDKVQQ 950
FLAGATPRKV IVVAGRLISL VI 972
Length:972
Mass (Da):108,408
Last modified:January 1, 1998 - v2
Checksum:i65286839DA51AFAE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti659 – 66810GGAEHAVLHL → AEPNMRCYIC in CAA94727. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14967 Genomic DNA. Translation: CAA75192.1.
Z70722 Genomic DNA. Translation: CAA94727.1.
AL583917 Genomic DNA. Translation: CAC29540.1.
PIRiT10023.
RefSeqiNP_301156.1. NC_002677.1.
WP_010907481.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29540; CAC29540; CAC29540.
GeneIDi908194.
KEGGimle:ML0032.
PATRICi18050166. VBIMycLep78757_0040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14967 Genomic DNA. Translation: CAA75192.1 .
Z70722 Genomic DNA. Translation: CAA94727.1 .
AL583917 Genomic DNA. Translation: CAC29540.1 .
PIRi T10023.
RefSeqi NP_301156.1. NC_002677.1.
WP_010907481.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q50192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0032.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29540 ; CAC29540 ; CAC29540 .
GeneIDi 908194.
KEGGi mle:ML0032.
PATRICi 18050166. VBIMycLep78757_0040.

Organism-specific databases

Lepromai ML0032.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiSYL_MYCLE
AccessioniPrimary (citable) accession number: Q50192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi