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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:ML1383
ORF Names:o410
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1383.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Dephospho-CoA kinasePRO_0000172963Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1383.

Structurei

3D structure databases

ProteinModelPortaliQ50178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 201199DPCKAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 410215UPF0157Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the CoaE family.Curated
In the C-terminal section; belongs to the UPF0157 (GrpB) family.Curated

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
COG2320. LUCA.
HOGENOMiHOG000020768.
KOiK00859.
OMAiTNVHIRV.
OrthoDBiPOG091H02KX.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR007344. GrpB/CoaE.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
PF04229. GrpB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCIGITGGI GAGKSLLSST FSQCGGIVVD GDVLAREVVQ PGTKGLSSLV
60 70 80 90 100
DAFGQDILLP GGALDRRALA VKAFRDDAAR NVLNGIVHPL VANRRAEIIA
110 120 130 140 150
AISEDAVVVE DIPLLVESGM AHLFPLVVVV HADVELRVRR LVEQRGVAET
160 170 180 190 200
DARARIAAQA SDEERRAVAD VWLDNSSTPE VLVQRARDLW YHRILPFAYN
210 220 230 240 250
LSQRQAVYAP AGLVTSDPIW LGQAKRIVAR LKTTCGHKAL RVDHIGSTAV
260 270 280 290 300
PHYPGFPDFQ AKDIIDIQIT VESLAMADEL ADPLLSAGYP RLEHVTGDAA
310 320 330 340 350
KTNARSTVDR YEHSSDPNLW HKRFHASADP GRPTYVHIRV AGWPNQQFGL
360 370 380 390 400
LFVDWLKANP GVRADYLDVK RTADRLAAGD MGRYADAKEP WLLDAYRRAW
410
EWADSTGWRL
Length:410
Mass (Da):44,976
Last modified:November 1, 1996 - v1
Checksum:i923F0408658A6A73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86366.1.
AL583921 Genomic DNA. Translation: CAC31764.1.
PIRiS77661.
RefSeqiNP_301984.1. NC_002677.1.
WP_010908305.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31764; CAC31764; CAC31764.
GeneIDi910513.
KEGGimle:ML1383.
PATRICi18055266. VBIMycLep78757_2566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86366.1.
AL583921 Genomic DNA. Translation: CAC31764.1.
PIRiS77661.
RefSeqiNP_301984.1. NC_002677.1.
WP_010908305.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ50178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1383.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31764; CAC31764; CAC31764.
GeneIDi910513.
KEGGimle:ML1383.
PATRICi18055266. VBIMycLep78757_2566.

Organism-specific databases

LepromaiML1383.

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
COG2320. LUCA.
HOGENOMiHOG000020768.
KOiK00859.
OMAiTNVHIRV.
OrthoDBiPOG091H02KX.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR007344. GrpB/CoaE.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
PF04229. GrpB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOAE_MYCLE
AccessioniPrimary (citable) accession number: Q50178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.