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Protein

Diaminopimelate decarboxylase

Gene

lysA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.UniRule annotation

Catalytic activityi

Meso-2,6-diaminoheptanedioate = L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes L-lysine from DL-2,6-diaminopimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Diaminopimelate decarboxylase (lysA)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from DL-2,6-diaminopimelate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei283Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei328SubstrateUniRule annotation1
Binding sitei369SubstrateUniRule annotation1
Binding sitei373SubstrateUniRule annotation1
Active sitei400Proton donorSequence analysis1
Binding sitei401SubstrateUniRule annotation1
Binding sitei430Pyridoxal phosphateUniRule annotation1
Binding sitei430SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processAmino-acid biosynthesis, Lysine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1228-MONOMER
UniPathwayiUPA00034; UER00027

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)
Short name:
DAP decarboxylaseUniRule annotation
Short name:
DAPDCUniRule annotation
Gene namesi
Name:lysAUniRule annotation
Ordered Locus Names:ML1128
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi

Organism-specific databases

LepromaiML1128

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499281 – 472Diaminopimelate decarboxylaseAdd BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ50140

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1128

Structurei

3D structure databases

ProteinModelPortaliQ50140
SMRiQ50140
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni325 – 328Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CU5 Bacteria
COG0019 LUCA
HOGENOMiHOG000045071
KOiK01586
OMAiVVGYICE
OrthoDBiPOG091H013X

Family and domain databases

CDDicd06828 PLPDE_III_DapDC, 1 hit
Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_02120 LysA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002986 DAP_deCOOHase_LysA
IPR022643 De-COase2_C
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43727:SF2 PTHR43727:SF2, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01181 DAPDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01048 lysA, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q50140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVHTAGPRH AEKTRHTATP QRVQPSDDLL RLASNVWPRN ITRDETGVAC
60 70 80 90 100
IAGNKLTDLA GEYGTPLFVI DEDDFRFRCR EIAAAFGGGE NVHYAAKAFL
110 120 130 140 150
CTEIARWIDE EGLSLDVCSG GELAVALHAS FPPERISLHG NNKSVAELKD
160 170 180 190 200
AVKAGVGYIV LDSTTEIERL DAIAGEAGIV QDVLVRLTVG VEAHTHEFIA
210 220 230 240 250
TAHEDQKFGL SVASGAAMAA VRRVFATDNL RLVGLHSHIG SQIFDVAGFE
260 270 280 290 300
LAAHRVIGLL CDIVGEFDPE KTAQLSIVDL GGGLGISYLP DDDPPPIFEL
310 320 330 340 350
AAKLGAIVSN ESAAVGLPVP KLMVEPGRAI AGPGTITLYE VGTIKDVDVS
360 370 380 390 400
ATAHRRYVSI DGGMSDNIRT ALYDAQYDVR LVSRTSDAPA APASIVGKHC
410 420 430 440 450
ESGDIVVRDT WVPDDLKPGD LVGVAATGAY CYSLSSRYNM LGRPAVVAVC
460 470
AGQARLILRR ETVDDLLSLE VR
Length:472
Mass (Da):50,278
Last modified:April 27, 2001 - v2
Checksum:iDB234E82D8274B39
GO

Sequence cautioni

The sequence AAA63102 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15186 Genomic DNA Translation: AAA63102.1 Different initiation.
AL583920 Genomic DNA Translation: CAC31509.1
PIRiB87050
RefSeqiNP_301822.1, NC_002677.1
WP_010908146.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31509; CAC31509; CAC31509
GeneIDi910222
KEGGimle:ML1128
PATRICifig|272631.5.peg.2050

Entry informationi

Entry nameiDCDA_MYCLE
AccessioniPrimary (citable) accession number: Q50140
Secondary accession number(s): Q9CC78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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