Q50130 (ECHA6_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable enoyl-CoA hydratase echA6
EC=4.2.1.17

Gene names

Name:	echA6
Ordered Locus Names:	ML2118
ORF Names:	u650af

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could possibly oxidize fatty acids using specific components By similarity.
Catalytic activity	(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
Sequence similarities	Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	enoyl-CoA hydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	Probable enoyl-CoA hydratase echA6		PRO_0000109334

Sequences

	Sequence		Length	Mass (Da)
	Q50130 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 08D7A556ED006C0C	FASTA	247	26,654
	10 20 30 40 50 60 MIGITQAEGV MTIELQRPER RNALNSQLIE KLREAVQKAS SADSEVSTRV IVLTGQGTVF 70 80 90 100 110 120 CAGADLSGDA FAADYPDRLI ELHRVMDAVP MPVIGAINGP AIGAGLQLAM QCDLRVVAPD 130 140 150 160 170 180 AYFQFPTSKY GLALDNWSIR RLSSLVGHGR ARAMLLTAEK LTADIALQTG MANRIGALAD 190 200 210 220 230 240 AQAWAAEVTG LAPLAIQHAK RVLNDDGSIE EAWPEHKKLF DKAWTSQDVI EAQVARVEKR PPKFQGA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U15184 Genomic DNA. Translation: AAA63046.1. AL583924 Genomic DNA. Translation: CAC31073.1.
PIR	A87174.
RefSeq	NP_302400.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q50130.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000028073; EBMYCP00000027679; EBMYCG00000028068.
GeneID	908912.
GenomeReviews	Gene locus ML2118 in contig AL450380_GR.
KEGG	mle:ML2118.
NMPDR	fig|272631.1.peg.1272.
PATRIC	18058147. VBIMycLep78757_3996.
Organism-specific databases
Leproma	ML2118.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015506.
HOGENOM	HBG748731.
OMA	WPEHKEL.
ProtClustDB	PRK07854.
Enzyme and pathway databases
BioCyc	MLEP272631:ML2118-MONOMER.
Family and domain databases
InterPro	IPR001753. Crotonase_core. IPR018376. Enoyl-CoA_hyd/isom_CS. [Graphical view]
KO	K01692.
Pfam	PF00378. ECH. 1 hit. [Graphical view]
PROSITE	PS00166. ENOYL_COA_HYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ECHA6_MYCLE

Accession

Primary (citable) accession number: Q50130

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program