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Protein

Divalent metal cation transporter MntH

Gene

mntH

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

H+-stimulated, divalent metal cation uptake system.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Divalent metal cation transporter MntHUniRule annotation
Gene namesi
Name:mntHUniRule annotation
Synonyms:bcg
Ordered Locus Names:ML2098
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2098.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalUniRule annotationAdd BLAST21
Transmembranei58 – 78HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 156HelicalUniRule annotationAdd BLAST23
Transmembranei169 – 189HelicalUniRule annotationAdd BLAST21
Transmembranei208 – 228HelicalUniRule annotationAdd BLAST21
Transmembranei256 – 276HelicalUniRule annotationAdd BLAST21
Transmembranei298 – 318HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21
Transmembranei363 – 383HelicalUniRule annotationAdd BLAST21
Transmembranei402 – 422HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126261 – 426Divalent metal cation transporter MntHAdd BLAST426

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2098.

Structurei

3D structure databases

ProteinModelPortaliQ50103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NRAMP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1914. LUCA.
HOGENOMiHOG000152205.
KOiK03322.
OMAiERYSATK.
OrthoDBiPOG091H056B.

Family and domain databases

HAMAPiMF_00221. NRAMP. 1 hit.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.

Sequencei

Sequence statusi: Complete.

Q50103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVNLTCLSE GNGSRGKALA ESTQAELKTS WYLLGPAFVA AIAYVDPGNV
60 70 80 90 100
AANVSSGAQF GYLQLWVVVV ANVLAGLVQY LSAKLGLVTG QSLPQAISKQ
110 120 130 140 150
MSHPFRLGFW LQAELVAMAT DVAEIVGGAI AFHILFRVSL LLGGVITGTV
160 170 180 190 200
SLLLLMVKDR RGQLLFERVI TGLLFVIVVG FTSSFFVATP SPEDMVNGLL
210 220 230 240 250
PRFQGTESVL LAAAIIGATV MPHAVYLHSG LALDRHGHPH AGRSRRRLLR
260 270 280 290 300
VTRLDVILAM TIAGIVNTAM LLVAAINLQH HQVTAYIEGT YTAIQDTLGA
310 320 330 340 350
TIAMLFAIGL LASSLASASV GAYAGALIMQ GLLQRSIPML IRRLITLCPA
360 370 380 390 400
IAILALGFDP TRALVLSQIV LSFGIPFAVL PLVKLTNNRG LMGNDTNHPA
410 420
TTVLGWAVAI LVSLLNVVLI YLTVTS
Length:426
Mass (Da):45,137
Last modified:August 29, 2001 - v2
Checksum:iBA28C88FC60D043C
GO

Sequence cautioni

The sequence AAA63075 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15184 Genomic DNA. Translation: AAA63075.1. Different initiation.
AL583924 Genomic DNA. Translation: CAC31053.1.
PIRiE87171.
RefSeqiNP_302396.1. NC_002677.1.
WP_010908716.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31053; CAC31053; CAC31053.
GeneIDi908932.
KEGGimle:ML2098.
PATRICi18058049. VBIMycLep78757_3948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15184 Genomic DNA. Translation: AAA63075.1. Different initiation.
AL583924 Genomic DNA. Translation: CAC31053.1.
PIRiE87171.
RefSeqiNP_302396.1. NC_002677.1.
WP_010908716.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ50103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31053; CAC31053; CAC31053.
GeneIDi908932.
KEGGimle:ML2098.
PATRICi18058049. VBIMycLep78757_3948.

Organism-specific databases

LepromaiML2098.

Phylogenomic databases

eggNOGiCOG1914. LUCA.
HOGENOMiHOG000152205.
KOiK03322.
OMAiERYSATK.
OrthoDBiPOG091H056B.

Family and domain databases

HAMAPiMF_00221. NRAMP. 1 hit.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
ProtoNetiSearch...

Entry informationi

Entry nameiMNTH_MYCLE
AccessioniPrimary (citable) accession number: Q50103
Secondary accession number(s): Q9CBE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.