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Protein

Phosphate import ATP-binding protein PstB

Gene

pstB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + phosphate(Out) = ADP + phosphate + phosphate(In).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Phosphate transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate import ATP-binding protein PstBUniRule annotation (EC:3.6.3.27UniRule annotation)
Alternative name(s):
ABC phosphate transporterUniRule annotation
Phosphate-transporting ATPaseUniRule annotation
Gene namesi
Name:pstBUniRule annotation
Synonyms:phoT
Ordered Locus Names:ML2189
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2189.

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Phosphate import ATP-binding protein PstBPRO_0000092842Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML2189.

Structurei

3D structure databases

ProteinModelPortaliQ50046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 247243ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1117. LUCA.
KOiK02036.
OMAiMTVEPRS.
OrthoDBiPOG091H01HF.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015850. ABC_transpr_PstB.
IPR027417. P-loop_NTPase.
IPR005670. Phosp_transpt1.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00972. 3a0107s01c2. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51238. PSTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRLDLKGV NIYYGSFQAV LDVSLAVLPR SVTAFIGASG CGKTTVLRTL
60 70 80 90 100
NRMHEVVPGA RVEGTVLLDD EDIYAPGIDP VGVRRAIGMV FQRPNPFPAM
110 120 130 140 150
SIRDNVVAGL KLQGVRNRKV LDDTAEYFLR GTNLWDEVKD RLDKPGGGLS
160 170 180 190 200
GGQQQRLCIA RAIAVQPDVL LMDEPCSSLD PISTMAIEEL IGELKQEYTI
210 220 230 240 250
VIVTHNMQQA ARVSDQTAFF NLEAVGRPGR LVEIDDTEKI FSNPTEKATE

DYISGRFG
Length:258
Mass (Da):28,280
Last modified:November 1, 1996 - v1
Checksum:i719712FE5741D237
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15182 Genomic DNA. Translation: AAA62990.1.
AL583924 Genomic DNA. Translation: CAC31144.1.
PIRiH87182.
RefSeqiNP_302434.1. NC_002677.1.
WP_010908754.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31144; CAC31144; CAC31144.
GeneIDi908843.
KEGGimle:ML2189.
PATRICi18058465. VBIMycLep78757_4151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15182 Genomic DNA. Translation: AAA62990.1.
AL583924 Genomic DNA. Translation: CAC31144.1.
PIRiH87182.
RefSeqiNP_302434.1. NC_002677.1.
WP_010908754.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ50046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2189.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31144; CAC31144; CAC31144.
GeneIDi908843.
KEGGimle:ML2189.
PATRICi18058465. VBIMycLep78757_4151.

Organism-specific databases

LepromaiML2189.

Phylogenomic databases

eggNOGiCOG1117. LUCA.
KOiK02036.
OMAiMTVEPRS.
OrthoDBiPOG091H01HF.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015850. ABC_transpr_PstB.
IPR027417. P-loop_NTPase.
IPR005670. Phosp_transpt1.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00972. 3a0107s01c2. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51238. PSTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSTB_MYCLE
AccessioniPrimary (citable) accession number: Q50046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.