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Protein

Probable M18 family aminopeptidase 2

Gene

apeB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791ZincSequence analysis
Metal bindingi156 – 1561ZincSequence analysis
Metal bindingi399 – 3991ZincSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM18.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable M18 family aminopeptidase 2 (EC:3.4.11.-)
Gene namesi
Name:apeB
Synonyms:pepC, pepX
Ordered Locus Names:ML2213
ORF Names:MLCB5.29
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Probable M18 family aminopeptidase 2PRO_0000173463Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ50022.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M18 family.Curated

Phylogenomic databases

eggNOGiENOG4105DFM. Bacteria.
COG1362. LUCA.
HOGENOMiHOG000253244.
OrthoDBiEOG664CHR.

Family and domain databases

Gene3Di2.30.250.10. 1 hit.
HAMAPiMF_00467. Aminopeptidase_M18_2.
InterProiIPR022984. M18_aminopeptidase_2.
IPR001948. Peptidase_M18.
IPR023358. Peptidase_M18_dom2.
[Graphical view]
PfamiPF02127. Peptidase_M18. 1 hit.
[Graphical view]
PRINTSiPR00932. AMINO1PTASE.

Sequencei

Sequence statusi: Complete.

Q50022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASAADLCE FINASPSPFH VCATVAGRLL DAGYAELSEV ERWPDHPGRY
60 70 80 90 100
FIVRAGSLVA WSAGQGVKAH APFRIVGAHT DSPNLRVKQH PDLLVAGWRV
110 120 130 140 150
VALQPYGGAW LNSWLDRDLG VSGRLSVRSA GKGSEITDRL VRIDDPILRV
160 170 180 190 200
PQLAIHLAED RKSLTLDPQR HVNAVWGVGD KAGSLLEYVA ERTGVAVADV
210 220 230 240 250
LAVDLMTHDL VPSMVIGADA NLLSAPRLDN QVSCYAGMEA LLASVPHDCL
260 270 280 290 300
PVLALFDHEE VGSTSDRGAR SNLLSTVLER IVLAAGGGRD DYLRRLPASL
310 320 330 340 350
LVSADMAHAT HPNYPECHEP SHLIEVNAGP VLKVHPNLRY ATDGRTAAAF
360 370 380 390 400
EVACQQAGVR LQRYEHRADR PCGSTIGPLA SARTGIPTVD VGAAQLAMHS
410 420
ARELMGAHDV AVYSAALQAF FSADLF
Length:426
Mass (Da):45,594
Last modified:October 24, 2001 - v2
Checksum:i582ADDD29C3A0A53
GO

Sequence cautioni

The sequence AAA62998.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB08404.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC31168.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15182 Genomic DNA. Translation: AAA62998.1. Different initiation.
Z95151 Genomic DNA. Translation: CAB08404.1. Different initiation.
AL583924 Genomic DNA. Translation: CAC31168.1. Different initiation.
PIRiH87185.
RefSeqiWP_010908772.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31168; CAC31168; CAC31168.
PATRICi18058539. VBIMycLep78757_4188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15182 Genomic DNA. Translation: AAA62998.1. Different initiation.
Z95151 Genomic DNA. Translation: CAB08404.1. Different initiation.
AL583924 Genomic DNA. Translation: CAC31168.1. Different initiation.
PIRiH87185.
RefSeqiWP_010908772.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ50022.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM18.002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31168; CAC31168; CAC31168.
PATRICi18058539. VBIMycLep78757_4188.

Organism-specific databases

LepromaiML2213.

Phylogenomic databases

eggNOGiENOG4105DFM. Bacteria.
COG1362. LUCA.
HOGENOMiHOG000253244.
OrthoDBiEOG664CHR.

Family and domain databases

Gene3Di2.30.250.10. 1 hit.
HAMAPiMF_00467. Aminopeptidase_M18_2.
InterProiIPR022984. M18_aminopeptidase_2.
IPR001948. Peptidase_M18.
IPR023358. Peptidase_M18_dom2.
[Graphical view]
PfamiPF02127. Peptidase_M18. 1 hit.
[Graphical view]
PRINTSiPR00932. AMINO1PTASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiAPEB_MYCLE
AccessioniPrimary (citable) accession number: Q50022
Secondary accession number(s): O08111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: October 24, 2001
Last modified: November 11, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.