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Q50008

- PPOX_MYCLE

UniProt

Q50008 - PPOX_MYCLE

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Protein

Protoporphyrinogen oxidase

Gene

hemY

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.By similarity

Catalytic activityi

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactori

Binds 1 FAD per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421FAD; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei393 – 3931FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156FADBy similarity
Nucleotide bindingi36 – 372FADBy similarity
Nucleotide bindingi58 – 614FADBy similarity
Nucleotide bindingi429 – 4313FADBy similarity

GO - Molecular functioni

  1. oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00251; UER00324.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoporphyrinogen oxidase (EC:1.3.3.4)
Short name:
PPO
Gene namesi
Name:hemY
Ordered Locus Names:ML1044
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1044.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Protoporphyrinogen oxidasePRO_0000135264Add
BLAST

Interactioni

Subunit structurei

Monomer. Homodimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi272631.ML1044.

Structurei

3D structure databases

ProteinModelPortaliQ50008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protoporphyrinogen oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1232.
HOGENOMiHOG000269479.
KOiK00231.
OMAiGVGIPVC.
OrthoDBiEOG6RFZTN.

Family and domain databases

Gene3Di3.90.660.20. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

Sequencei

Sequence statusi: Complete.

Q50008-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSRSYCVVG GGISGLTAAY RLRVATGDDV AITLFDPGDR LGGVLRTECV
60 70 80 90 100
GGQPMDLGAE AFLLRRPEVP ALLAELGLSE RQRATTDARP LIYSQQRLHS
110 120 130 140 150
LPPDTVAGIP SSATSVAGLV DDATVARIGA EAVRPLSWEP GSDPAMAELV
160 170 180 190 200
ADRFGEQAVA RLVDPLLGGV YAGSAATIGL RAGAPSVAAA LDCGATSLME
210 220 230 240 250
AVRQGLPPVA AGPVFGALDG GYQVLIDELV RRSRLQWVAA TVVGLDRGTC
260 270 280 290 300
GWTLVDDTGA CWSADGVILA VPAPRLVRLL QQIAPRTVAA ASRIVSASSA
310 320 330 340 350
VVALSVPRDT TFPQNSGVLV ASGERLRAKA VTLSSRKWGL QGDTQLVRLS
360 370 380 390 400
FGKFGDQVAS TASDDELLAW AVSDLAAVFD VTVDPVDVCV QRWIDAMPQY
410 420 430 440 450
GPGHADLVAE VRAGLPPTLV VAGSHMDGIG VPACISAAGR AIEALQAEVA

R
Length:451
Mass (Da):46,580
Last modified:November 1, 1996 - v1
Checksum:iDF76EE1655CA2056
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15181 Genomic DNA. Translation: AAA62958.1.
AL583920 Genomic DNA. Translation: CAC31425.1.
PIRiF87039.
RefSeqiNP_301770.1. NC_002677.1.
WP_010908094.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31425; CAC31425; CAC31425.
GeneIDi910131.
KEGGimle:ML1044.
PATRICi18053862. VBIMycLep78757_1876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15181 Genomic DNA. Translation: AAA62958.1 .
AL583920 Genomic DNA. Translation: CAC31425.1 .
PIRi F87039.
RefSeqi NP_301770.1. NC_002677.1.
WP_010908094.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q50008.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31425 ; CAC31425 ; CAC31425 .
GeneIDi 910131.
KEGGi mle:ML1044.
PATRICi 18053862. VBIMycLep78757_1876.

Organism-specific databases

Lepromai ML1044.

Phylogenomic databases

eggNOGi COG1232.
HOGENOMi HOG000269479.
KOi K00231.
OMAi GVGIPVC.
OrthoDBi EOG6RFZTN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00324 .

Family and domain databases

Gene3Di 3.90.660.20. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPPOX_MYCLE
AccessioniPrimary (citable) accession number: Q50008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3