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Q50008

- PPOX_MYCLE

UniProt

Q50008 - PPOX_MYCLE

Protein

Protoporphyrinogen oxidase

Gene

hemY

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.By similarity

    Catalytic activityi

    Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei242 – 2421FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei393 – 3931FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156FADBy similarity
    Nucleotide bindingi36 – 372FADBy similarity
    Nucleotide bindingi58 – 614FADBy similarity
    Nucleotide bindingi429 – 4313FADBy similarity

    GO - Molecular functioni

    1. oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00324.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoporphyrinogen oxidase (EC:1.3.3.4)
    Short name:
    PPO
    Gene namesi
    Name:hemY
    Ordered Locus Names:ML1044
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1044.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 451451Protoporphyrinogen oxidasePRO_0000135264Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. Homodimer By similarity.By similarity

    Protein-protein interaction databases

    STRINGi272631.ML1044.

    Structurei

    3D structure databases

    ProteinModelPortaliQ50008.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protoporphyrinogen oxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG1232.
    HOGENOMiHOG000269479.
    KOiK00231.
    OMAiGVGIPVC.
    OrthoDBiEOG6RFZTN.

    Family and domain databases

    Gene3Di3.90.660.20. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q50008-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSRSYCVVG GGISGLTAAY RLRVATGDDV AITLFDPGDR LGGVLRTECV    50
    GGQPMDLGAE AFLLRRPEVP ALLAELGLSE RQRATTDARP LIYSQQRLHS 100
    LPPDTVAGIP SSATSVAGLV DDATVARIGA EAVRPLSWEP GSDPAMAELV 150
    ADRFGEQAVA RLVDPLLGGV YAGSAATIGL RAGAPSVAAA LDCGATSLME 200
    AVRQGLPPVA AGPVFGALDG GYQVLIDELV RRSRLQWVAA TVVGLDRGTC 250
    GWTLVDDTGA CWSADGVILA VPAPRLVRLL QQIAPRTVAA ASRIVSASSA 300
    VVALSVPRDT TFPQNSGVLV ASGERLRAKA VTLSSRKWGL QGDTQLVRLS 350
    FGKFGDQVAS TASDDELLAW AVSDLAAVFD VTVDPVDVCV QRWIDAMPQY 400
    GPGHADLVAE VRAGLPPTLV VAGSHMDGIG VPACISAAGR AIEALQAEVA 450
    R 451
    Length:451
    Mass (Da):46,580
    Last modified:November 1, 1996 - v1
    Checksum:iDF76EE1655CA2056
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15181 Genomic DNA. Translation: AAA62958.1.
    AL583920 Genomic DNA. Translation: CAC31425.1.
    PIRiF87039.
    RefSeqiNP_301770.1. NC_002677.1.
    WP_010908094.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31425; CAC31425; CAC31425.
    GeneIDi910131.
    KEGGimle:ML1044.
    PATRICi18053862. VBIMycLep78757_1876.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15181 Genomic DNA. Translation: AAA62958.1 .
    AL583920 Genomic DNA. Translation: CAC31425.1 .
    PIRi F87039.
    RefSeqi NP_301770.1. NC_002677.1.
    WP_010908094.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q50008.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1044.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31425 ; CAC31425 ; CAC31425 .
    GeneIDi 910131.
    KEGGi mle:ML1044.
    PATRICi 18053862. VBIMycLep78757_1876.

    Organism-specific databases

    Lepromai ML1044.

    Phylogenomic databases

    eggNOGi COG1232.
    HOGENOMi HOG000269479.
    KOi K00231.
    OMAi GVGIPVC.
    OrthoDBi EOG6RFZTN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00324 .

    Family and domain databases

    Gene3Di 3.90.660.20. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiPPOX_MYCLE
    AccessioniPrimary (citable) accession number: Q50008
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3