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Q50008 (PPOX_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protoporphyrinogen oxidase

Short name=PPO
EC=1.3.3.4
Gene names
Name:hemY
Ordered Locus Names:ML1044
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX By similarity.

Catalytic activity

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactor

Binds 1 FAD per subunit By similarity.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.

Subunit structure

Monomer. Homodimer By similarity.

Subcellular location

Cytoplasm By similarity. Membrane By similarity.

Sequence similarities

Belongs to the protoporphyrinogen oxidase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
Membrane
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxygen-dependent protoporphyrinogen oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Protoporphyrinogen oxidase
PRO_0000135264

Regions

Nucleotide binding10 – 156FAD By similarity
Nucleotide binding36 – 372FAD By similarity
Nucleotide binding58 – 614FAD By similarity
Nucleotide binding429 – 4313FAD By similarity

Sites

Binding site2421FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site3931FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q50008 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: DF76EE1655CA2056

FASTA45146,580
        10         20         30         40         50         60 
MTSRSYCVVG GGISGLTAAY RLRVATGDDV AITLFDPGDR LGGVLRTECV GGQPMDLGAE 

        70         80         90        100        110        120 
AFLLRRPEVP ALLAELGLSE RQRATTDARP LIYSQQRLHS LPPDTVAGIP SSATSVAGLV 

       130        140        150        160        170        180 
DDATVARIGA EAVRPLSWEP GSDPAMAELV ADRFGEQAVA RLVDPLLGGV YAGSAATIGL 

       190        200        210        220        230        240 
RAGAPSVAAA LDCGATSLME AVRQGLPPVA AGPVFGALDG GYQVLIDELV RRSRLQWVAA 

       250        260        270        280        290        300 
TVVGLDRGTC GWTLVDDTGA CWSADGVILA VPAPRLVRLL QQIAPRTVAA ASRIVSASSA 

       310        320        330        340        350        360 
VVALSVPRDT TFPQNSGVLV ASGERLRAKA VTLSSRKWGL QGDTQLVRLS FGKFGDQVAS 

       370        380        390        400        410        420 
TASDDELLAW AVSDLAAVFD VTVDPVDVCV QRWIDAMPQY GPGHADLVAE VRAGLPPTLV 

       430        440        450 
VAGSHMDGIG VPACISAAGR AIEALQAEVA R 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15181 Genomic DNA. Translation: AAA62958.1.
AL583920 Genomic DNA. Translation: CAC31425.1.
PIRF87039.
RefSeqNP_301770.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ50008.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1044.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31425; CAC31425; CAC31425.
GeneID910131.
KEGGmle:ML1044.
PATRIC18053862. VBIMycLep78757_1876.

Organism-specific databases

LepromaML1044.
CMRSearch...

Phylogenomic databases

eggNOGCOG1232.
HOGENOMHOG000269479.
KOK00231.
OMAGVGIPVC.
OrthoDBEOG6RFZTN.

Enzyme and pathway databases

UniPathwayUPA00251; UER00324.

Family and domain databases

Gene3D3.90.660.20. 1 hit.
InterProIPR002937. Amino_oxidase.
IPR004572. Protoporphyrinogen_oxidase.
IPR027418. Protoporphyrinogen_oxidase_C.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00562. proto_IX_ox. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPOX_MYCLE
AccessionPrimary (citable) accession number: Q50008
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways