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Q4ZZG6

- HIS3_PSEU2

UniProt

Q4ZZG6 - HIS3_PSEU2

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Protein

Phosphoribosyl-AMP cyclohydrolase

Gene
hisI, Psyr_0386
Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP By similarity.

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi77 – 771Magnesium By similarity
Metal bindingi78 – 781Zinc; shared with dimeric partner By similarity
Metal bindingi79 – 791Magnesium By similarity
Metal bindingi81 – 811Magnesium By similarity
Metal bindingi95 – 951Zinc; shared with dimeric partner By similarity
Metal bindingi102 – 1021Zinc; shared with dimeric partner By similarity

GO - Molecular functioni

  1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciPSYR205918:GJ94-387-MONOMER.
UniPathwayiUPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-AMP cyclohydrolase (EC:3.5.4.19)
Short name:
PRA-CH
Gene namesi
Name:hisI
Ordered Locus Names:Psyr_0386
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
ProteomesiUP000000426: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130Phosphoribosyl-AMP cyclohydrolaseUniRule annotationPRO_0000229838Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi205918.Psyr_0386.

Structurei

3D structure databases

ProteinModelPortaliQ4ZZG6.
SMRiQ4ZZG6. Positions 7-120.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-CH family.

Phylogenomic databases

eggNOGiCOG0139.
HOGENOMiHOG000277504.
KOiK01496.
OMAiICAYANE.
OrthoDBiEOG6PGKB6.

Family and domain databases

HAMAPiMF_01021. HisI.
InterProiIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q4ZZG6-1 [UniParc]FASTAAdd to Basket

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MKDWLDEIHW NSDGLVPAIA QDHKTGRVLM MAWMNREALS LTAAENRAIY    50
WSRSRGKLWR KGEESGHVQK LHELRLDCDA DVIILMVEQI GGIACHTGRE 100
SCFYRVYEKS GWKTVDPVLK DPDAIYPAGH 130
Length:130
Mass (Da):14,892
Last modified:June 7, 2005 - v1
Checksum:i15BE6CF461B371D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY35456.1.
RefSeqiWP_003403068.1. NC_007005.1.
YP_233494.1. NC_007005.1.

Genome annotation databases

EnsemblBacteriaiAAY35456; AAY35456; Psyr_0386.
GeneIDi3365862.
KEGGipsb:Psyr_0386.
PATRICi19981187. VBIPseSyr42314_0399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY35456.1 .
RefSeqi WP_003403068.1. NC_007005.1.
YP_233494.1. NC_007005.1.

3D structure databases

ProteinModelPortali Q4ZZG6.
SMRi Q4ZZG6. Positions 7-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205918.Psyr_0386.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY35456 ; AAY35456 ; Psyr_0386 .
GeneIDi 3365862.
KEGGi psb:Psyr_0386.
PATRICi 19981187. VBIPseSyr42314_0399.

Phylogenomic databases

eggNOGi COG0139.
HOGENOMi HOG000277504.
KOi K01496.
OMAi ICAYANE.
OrthoDBi EOG6PGKB6.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00008 .
BioCyci PSYR205918:GJ94-387-MONOMER.

Family and domain databases

HAMAPi MF_01021. HisI.
InterProi IPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view ]
Pfami PF01502. PRA-CH. 1 hit.
[Graphical view ]
ProDomi PD002610. PRA_CycHdrlase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B728a.

Entry informationi

Entry nameiHIS3_PSEU2
AccessioniPrimary (citable) accession number: Q4ZZG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 7, 2005
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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