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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciPSYR205918:GJ94-598-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Psyr_0595
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
ProteomesiUP000000426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Nicotinate phosphoribosyltransferasePRO_1000025008Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205918.Psyr_0595.

Structurei

3D structure databases

ProteinModelPortaliQ4ZYV7.
SMRiQ4ZYV7. Positions 1-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4ZYV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESAFSNRI VQSLLDTDFY KLTMMQAVLH NYPNVDVEWE FRCRNGEDLR
60 70 80 90 100
PYLDEIKHQI ELLCELSLSP EHLAFLERIT FIKPDFLRFL GLFRFNTRYV
110 120 130 140 150
KTTIENDELC IRLHGPWLHV ILFEVPLLAI VSEVRNRHRY PDTLLSQARD
160 170 180 190 200
RLYDKFEWLT THATTDELAE LKVADFGTRR RFSYRVQEEM LGVLKNDFPG
210 220 230 240 250
QFVGTSNVHL ARQLDLKPLG TMAHEWIMAH QQLGPRLIDS QIAALDCWVR
260 270 280 290 300
EYRGLLGIAL TDCITTDAFL NDFDLYFAKL FDGLRHDSGD PVKWAEKCIS
310 320 330 340 350
HYQKLGIDPM SKTLVFSDGL NLPKALDIFR ALRGRINVSF GIGTNLTADI
360 370 380 390 400
PGIAPMNMVL KMTACAGQAV AKISDEPGKT QCKDPNFVAY LRHVFKVPDL

PSPEKPA
Length:407
Mass (Da):46,678
Last modified:June 7, 2005 - v1
Checksum:i721ACA2AF017D55C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000075 Genomic DNA. Translation: AAY35665.1.
RefSeqiYP_233703.1. NC_007005.1.

Genome annotation databases

EnsemblBacteriaiAAY35665; AAY35665; Psyr_0595.
GeneIDi3366073.
KEGGipsb:Psyr_0595.
PATRICi19981629. VBIPseSyr42314_0618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000075 Genomic DNA. Translation: AAY35665.1.
RefSeqiYP_233703.1. NC_007005.1.

3D structure databases

ProteinModelPortaliQ4ZYV7.
SMRiQ4ZYV7. Positions 1-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205918.Psyr_0595.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY35665; AAY35665; Psyr_0595.
GeneIDi3366073.
KEGGipsb:Psyr_0595.
PATRICi19981629. VBIPseSyr42314_0618.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
BioCyciPSYR205918:GJ94-598-MONOMER.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B728a.

Entry informationi

Entry nameiPNCB_PSEU2
AccessioniPrimary (citable) accession number: Q4ZYV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 7, 2005
Last modified: February 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.