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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciPSYR205918:G1G4J-925-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesi
Name:lldDUniRule annotation
Ordered Locus Names:Psyr_0908
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
Proteomesi
  • UP000000426 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002063431 – 380L-lactate dehydrogenaseAdd BLAST380

Proteomic databases

PRIDEiQ4ZY06

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi205918.Psyr_0908

Structurei

3D structure databases

ProteinModelPortaliQ4ZY06
SMRiQ4ZY06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 380FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST380

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMF Bacteria
COG1304 LUCA
HOGENOMiHOG000217464
KOiK00101
OMAiMQLYIYK
OrthoDBiPOG091H00L7

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01559 L_lact_dehydr, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
IPR020920 LldD
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4ZY06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISSASDYR AAAKRKLPRF LFDYIDGGAY AEHTLRANGS DLADISLRQR
60 70 80 90 100
VLKNVDNVSL ETRLFGESLA MPIILSPVGL SGMYARRGEV QVARAAANKR
110 120 130 140 150
IPFCLSTVSV CSIEEVASQS DQAIWFQLYV LKDRGFMKNA LERAKAAGVT
160 170 180 190 200
TLVFTVDMPT PGARYRDAHS GMSGPYAAPR RILQAMTKPD WALNVGLLGR
210 220 230 240 250
PHDLGNISRY LGKATTLEDY VGWLANNFDP SISWKDLEWI REFWQGPMII
260 270 280 290 300
KGILDPQDAR DALSFGADGI VVSNHGGRQL DGVLSTAKAL PPIVQAVGSD
310 320 330 340 350
LTVLADSGIR SGLDVVRMLA LGAKGVLLGR SMAYALGADG QRGVENMLDI
360 370 380
FAREMHVAMT LTGVTSIEQI DASILVKAVA
Length:380
Mass (Da):41,125
Last modified:June 7, 2005 - v1
Checksum:iCBCB3F1C76A7F6E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000075 Genomic DNA Translation: AAY35966.1
RefSeqiWP_011266707.1, NC_007005.1
YP_234004.1, NC_007005.1

Genome annotation databases

EnsemblBacteriaiAAY35966; AAY35966; Psyr_0908
GeneIDi3366400
KEGGipsb:Psyr_0908
PATRICifig|205918.7.peg.938

Similar proteinsi

Entry informationi

Entry nameiLLDD_PSEU2
AccessioniPrimary (citable) accession number: Q4ZY06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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