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Q4ZY06

- LLDD_PSEU2

UniProt

Q4ZY06 - LLDD_PSEU2

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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactori

FMN.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241SubstrateUniRule annotation
Binding sitei106 – 1061FMNUniRule annotation
Binding sitei127 – 1271FMNUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Binding sitei155 – 1551FMNUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Binding sitei251 – 2511FMNUniRule annotation
Active sitei275 – 2751Proton acceptorUniRule annotation
Binding sitei278 – 2781SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi306 – 33025FMNUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. lactate dehydrogenase activity Source: InterPro

GO - Biological processi

  1. lactate oxidation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciPSYR205918:GJ94-925-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesi
Name:lldDUniRule annotation
Ordered Locus Names:Psyr_0908
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
ProteomesiUP000000426: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380L-lactate dehydrogenasePRO_0000206343Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi205918.Psyr_0908.

Structurei

3D structure databases

ProteinModelPortaliQ4ZY06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 380380FMN hydroxy acid dehydrogenaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation
Contains 1 FMN hydroxy acid dehydrogenase domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1304.
HOGENOMiHOG000217464.
KOiK00101.
OMAiDCTLLGR.
OrthoDBiEOG6HMXBG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01559. L_lact_dehydr.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ZY06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIISSASDYR AAAKRKLPRF LFDYIDGGAY AEHTLRANGS DLADISLRQR
60 70 80 90 100
VLKNVDNVSL ETRLFGESLA MPIILSPVGL SGMYARRGEV QVARAAANKR
110 120 130 140 150
IPFCLSTVSV CSIEEVASQS DQAIWFQLYV LKDRGFMKNA LERAKAAGVT
160 170 180 190 200
TLVFTVDMPT PGARYRDAHS GMSGPYAAPR RILQAMTKPD WALNVGLLGR
210 220 230 240 250
PHDLGNISRY LGKATTLEDY VGWLANNFDP SISWKDLEWI REFWQGPMII
260 270 280 290 300
KGILDPQDAR DALSFGADGI VVSNHGGRQL DGVLSTAKAL PPIVQAVGSD
310 320 330 340 350
LTVLADSGIR SGLDVVRMLA LGAKGVLLGR SMAYALGADG QRGVENMLDI
360 370 380
FAREMHVAMT LTGVTSIEQI DASILVKAVA
Length:380
Mass (Da):41,125
Last modified:June 7, 2005 - v1
Checksum:iCBCB3F1C76A7F6E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY35966.1.
RefSeqiWP_011266707.1. NC_007005.1.
YP_234004.1. NC_007005.1.

Genome annotation databases

EnsemblBacteriaiAAY35966; AAY35966; Psyr_0908.
GeneIDi3366400.
KEGGipsb:Psyr_0908.
PATRICi19982295. VBIPseSyr42314_0938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY35966.1 .
RefSeqi WP_011266707.1. NC_007005.1.
YP_234004.1. NC_007005.1.

3D structure databases

ProteinModelPortali Q4ZY06.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205918.Psyr_0908.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY35966 ; AAY35966 ; Psyr_0908 .
GeneIDi 3366400.
KEGGi psb:Psyr_0908.
PATRICi 19982295. VBIPseSyr42314_0938.

Phylogenomic databases

eggNOGi COG1304.
HOGENOMi HOG000217464.
KOi K00101.
OMAi DCTLLGR.
OrthoDBi EOG6HMXBG.

Enzyme and pathway databases

BioCyci PSYR205918:GJ94-925-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01559. L_lact_dehydr.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B728a.

Entry informationi

Entry nameiLLDD_PSEU2
AccessioniPrimary (citable) accession number: Q4ZY06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3