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Q4ZXH2 (GCSP_PSEU2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Psyr_1096
OrganismPseudomonas syringae pv. syringae (strain B728a) [Complete proteome] [HAMAP]
Taxonomic identifier205918 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227121

Amino acid modifications

Modified residue7061N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4ZXH2 [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: 4E1B3FA1A2B4FCD6

FASTA954103,677
        10         20         30         40         50         60 
MTDRIELTTA NEFIARHIGP RAADELAMLQ TLGFDSIEAL SESVIPESIK GTSVLNLPAG 

        70         80         90        100        110        120 
QSEADALASI KAIASKNQLF KTYIGQGYYN THTPAPILRN LLENPAWYTA YTPYQPEISQ 

       130        140        150        160        170        180 
GRLESLLNFQ TLISDLTGLP IANASLLDEA TAAAEAMTFC KRLSKNKASQ QFFASSHCHP 

       190        200        210        220        230        240 
QTLDVLRTRA EPLGITVVVA DEHELGDVSD YFGALLQYPA SNGDVFDYRE LVERFHAANA 

       250        260        270        280        290        300 
LVAVAADLLA LTLLTPPGEF GADVAIGSAQ RFGVPLGFGG PHAAYFSTRD AFKRDMPGRL 

       310        320        330        340        350        360 
VGVSVDRHGK QALRLAMQTR EQHIRREKAT SNICTAQVLL ANIASMYAVY HGPRGLTQIA 

       370        380        390        400        410        420 
NRVHQLTAIL AEGLSTLGLN AEQAFFFDSL TLHTGDRTAA LHAAARARHI NLREIDDQRL 

       430        440        450        460        470        480 
GLSLDETTSQ SAVETLWAIF ANDGQSLPDF AALADSVQSR LPAGLLRQSA ILSHPVFNRY 

       490        500        510        520        530        540 
HSETELMRYL RKLADKDLAL DRTMIPLGSC TMKLNAASEM IPVTWAEFGN LHPFAPAEQS 

       550        560        570        580        590        600 
AGYQQLTDEL EAMLCAATGY DAISLQPNAG SQGEYAGLLA IRAYHQSRGD EHRDICLIPS 

       610        620        630        640        650        660 
SAHGTNPATA NMAGMRVVVT ACDARGNVDI EDLRAKAVQH RDQLAAIMIT YPSTHGVFEE 

       670        680        690        700        710        720 
GIREICGIVH DNGGQVYIDG ANMNAMVGLC APGKFGGDVS HLNLHKTFCI PHGGGGPGVG 

       730        740        750        760        770        780 
PIGVKSHLAP FMPGHARMER KEGAVCAAPF GSASILPITW MYIRMMGGEG LKRASQLAIL 

       790        800        810        820        830        840 
NANYISRRLE EHYPVLYTGS NGLVAHECIL DLRPIKDSSG ISVDDVAKRL IDFGFHAPTM 

       850        860        870        880        890        900 
SFPVAGTLMI EPTESESREE LDRFCDAMIK IREEIRAVEN GTLDKDDNPL KNAPHTAAEI 

       910        920        930        940        950 
VGQWSHPYSR EQAVYPVDSL IENKYWPPVG RVDNVFGDRN LVCACPSIEN YQEA 

« Hide

References

[1]"Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000."
Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A., Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S., Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M., Kyrpides N.C., Ivanova N., Lindow S.E.
Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B728a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000075 Genomic DNA. Translation: AAY36150.1.
RefSeqYP_234188.1. NC_007005.1.

3D structure databases

ProteinModelPortalQ4ZXH2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205918.Psyr_1096.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY36150; AAY36150; Psyr_1096.
GeneID3366590.
KEGGpsb:Psyr_1096.
PATRIC19982677. VBIPseSyr42314_1127.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycPSYR205918:GJ94-1115-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PSEU2
AccessionPrimary (citable) accession number: Q4ZXH2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 7, 2005
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families