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Q4ZXH2

- GCSP_PSEU2

UniProt

Q4ZXH2 - GCSP_PSEU2

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Psyr_1096
Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPSYR205918:GJ94-1115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Psyr_1096
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
ProteomesiUP000000426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei706 – 7061N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi205918.Psyr_1096.

Structurei

3D structure databases

ProteinModelPortaliQ4ZXH2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiERRDICL.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4ZXH2-1 [UniParc]FASTAAdd to Basket

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MTDRIELTTA NEFIARHIGP RAADELAMLQ TLGFDSIEAL SESVIPESIK    50
GTSVLNLPAG QSEADALASI KAIASKNQLF KTYIGQGYYN THTPAPILRN 100
LLENPAWYTA YTPYQPEISQ GRLESLLNFQ TLISDLTGLP IANASLLDEA 150
TAAAEAMTFC KRLSKNKASQ QFFASSHCHP QTLDVLRTRA EPLGITVVVA 200
DEHELGDVSD YFGALLQYPA SNGDVFDYRE LVERFHAANA LVAVAADLLA 250
LTLLTPPGEF GADVAIGSAQ RFGVPLGFGG PHAAYFSTRD AFKRDMPGRL 300
VGVSVDRHGK QALRLAMQTR EQHIRREKAT SNICTAQVLL ANIASMYAVY 350
HGPRGLTQIA NRVHQLTAIL AEGLSTLGLN AEQAFFFDSL TLHTGDRTAA 400
LHAAARARHI NLREIDDQRL GLSLDETTSQ SAVETLWAIF ANDGQSLPDF 450
AALADSVQSR LPAGLLRQSA ILSHPVFNRY HSETELMRYL RKLADKDLAL 500
DRTMIPLGSC TMKLNAASEM IPVTWAEFGN LHPFAPAEQS AGYQQLTDEL 550
EAMLCAATGY DAISLQPNAG SQGEYAGLLA IRAYHQSRGD EHRDICLIPS 600
SAHGTNPATA NMAGMRVVVT ACDARGNVDI EDLRAKAVQH RDQLAAIMIT 650
YPSTHGVFEE GIREICGIVH DNGGQVYIDG ANMNAMVGLC APGKFGGDVS 700
HLNLHKTFCI PHGGGGPGVG PIGVKSHLAP FMPGHARMER KEGAVCAAPF 750
GSASILPITW MYIRMMGGEG LKRASQLAIL NANYISRRLE EHYPVLYTGS 800
NGLVAHECIL DLRPIKDSSG ISVDDVAKRL IDFGFHAPTM SFPVAGTLMI 850
EPTESESREE LDRFCDAMIK IREEIRAVEN GTLDKDDNPL KNAPHTAAEI 900
VGQWSHPYSR EQAVYPVDSL IENKYWPPVG RVDNVFGDRN LVCACPSIEN 950
YQEA 954
Length:954
Mass (Da):103,677
Last modified:June 7, 2005 - v1
Checksum:i4E1B3FA1A2B4FCD6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY36150.1.
RefSeqiYP_234188.1. NC_007005.1.

Genome annotation databases

EnsemblBacteriaiAAY36150; AAY36150; Psyr_1096.
GeneIDi3366590.
KEGGipsb:Psyr_1096.
PATRICi19982677. VBIPseSyr42314_1127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY36150.1 .
RefSeqi YP_234188.1. NC_007005.1.

3D structure databases

ProteinModelPortali Q4ZXH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205918.Psyr_1096.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY36150 ; AAY36150 ; Psyr_1096 .
GeneIDi 3366590.
KEGGi psb:Psyr_1096.
PATRICi 19982677. VBIPseSyr42314_1127.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi ERRDICL.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PSYR205918:GJ94-1115-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B728a.

Entry informationi

Entry nameiGCSP_PSEU2
AccessioniPrimary (citable) accession number: Q4ZXH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 7, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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