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Q4ZXH2

- GCSP_PSEU2

UniProt

Q4ZXH2 - GCSP_PSEU2

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPSYR205918:GJ94-1115-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Psyr_1096
    OrganismiPseudomonas syringae pv. syringae (strain B728a)
    Taxonomic identifieri205918 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
    ProteomesiUP000000426: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000227121Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei706 – 7061N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi205918.Psyr_1096.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ZXH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiERRDICL.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4ZXH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDRIELTTA NEFIARHIGP RAADELAMLQ TLGFDSIEAL SESVIPESIK    50
    GTSVLNLPAG QSEADALASI KAIASKNQLF KTYIGQGYYN THTPAPILRN 100
    LLENPAWYTA YTPYQPEISQ GRLESLLNFQ TLISDLTGLP IANASLLDEA 150
    TAAAEAMTFC KRLSKNKASQ QFFASSHCHP QTLDVLRTRA EPLGITVVVA 200
    DEHELGDVSD YFGALLQYPA SNGDVFDYRE LVERFHAANA LVAVAADLLA 250
    LTLLTPPGEF GADVAIGSAQ RFGVPLGFGG PHAAYFSTRD AFKRDMPGRL 300
    VGVSVDRHGK QALRLAMQTR EQHIRREKAT SNICTAQVLL ANIASMYAVY 350
    HGPRGLTQIA NRVHQLTAIL AEGLSTLGLN AEQAFFFDSL TLHTGDRTAA 400
    LHAAARARHI NLREIDDQRL GLSLDETTSQ SAVETLWAIF ANDGQSLPDF 450
    AALADSVQSR LPAGLLRQSA ILSHPVFNRY HSETELMRYL RKLADKDLAL 500
    DRTMIPLGSC TMKLNAASEM IPVTWAEFGN LHPFAPAEQS AGYQQLTDEL 550
    EAMLCAATGY DAISLQPNAG SQGEYAGLLA IRAYHQSRGD EHRDICLIPS 600
    SAHGTNPATA NMAGMRVVVT ACDARGNVDI EDLRAKAVQH RDQLAAIMIT 650
    YPSTHGVFEE GIREICGIVH DNGGQVYIDG ANMNAMVGLC APGKFGGDVS 700
    HLNLHKTFCI PHGGGGPGVG PIGVKSHLAP FMPGHARMER KEGAVCAAPF 750
    GSASILPITW MYIRMMGGEG LKRASQLAIL NANYISRRLE EHYPVLYTGS 800
    NGLVAHECIL DLRPIKDSSG ISVDDVAKRL IDFGFHAPTM SFPVAGTLMI 850
    EPTESESREE LDRFCDAMIK IREEIRAVEN GTLDKDDNPL KNAPHTAAEI 900
    VGQWSHPYSR EQAVYPVDSL IENKYWPPVG RVDNVFGDRN LVCACPSIEN 950
    YQEA 954
    Length:954
    Mass (Da):103,677
    Last modified:June 7, 2005 - v1
    Checksum:i4E1B3FA1A2B4FCD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000075 Genomic DNA. Translation: AAY36150.1.
    RefSeqiYP_234188.1. NC_007005.1.

    Genome annotation databases

    EnsemblBacteriaiAAY36150; AAY36150; Psyr_1096.
    GeneIDi3366590.
    KEGGipsb:Psyr_1096.
    PATRICi19982677. VBIPseSyr42314_1127.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000075 Genomic DNA. Translation: AAY36150.1 .
    RefSeqi YP_234188.1. NC_007005.1.

    3D structure databases

    ProteinModelPortali Q4ZXH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205918.Psyr_1096.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY36150 ; AAY36150 ; Psyr_1096 .
    GeneIDi 3366590.
    KEGGi psb:Psyr_1096.
    PATRICi 19982677. VBIPseSyr42314_1127.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi ERRDICL.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PSYR205918:GJ94-1115-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B728a.

    Entry informationi

    Entry nameiGCSP_PSEU2
    AccessioniPrimary (citable) accession number: Q4ZXH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3