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Q4ZWR5

- LPXB_PSEU2

UniProt

Q4ZWR5 - LPXB_PSEU2

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPSYR205918:GJ94-1376-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Psyr_1356
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
ProteomesiUP000000426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Lipid-A-disaccharide synthasePRO_0000255210Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205918.Psyr_1356.

Structurei

3D structure databases

ProteinModelPortaliQ4ZWR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4ZWR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSPLCIALV AGEASGDILG SGLMRALKVR HPDIRFIGVG GPLMEAEGMQ
60 70 80 90 100
SSFPMERLSV MGLVEVLGRL RELLARRKLL VQTLINEKPD VFIGIDAPDF
110 120 130 140 150
TLNIELQLRR AGIKTVHYVS PSVWAWRQKR VLKIREGCDL MLTLLPFEAR
160 170 180 190 200
FYEEQGVPVR FVGHPLADTI PLESDRAGAR AGLGLAQETP VVALMPGSRG
210 220 230 240 250
GEVGRLGGLF FDTAERLLAR CPELRFVLPC ASPQRRAQVE QLLQGRDLPV
260 270 280 290 300
TLLDGQSHVA LAACDAVLIA SGTATLEALL YKRPMVVAYR LAPLTFWILK
310 320 330 340 350
RMVKSPYVSL PNLLAQRLLV PELLQDDATP EALARTLLPL IDDGREQTAG
360 370 380
FDAIHRILRR DASNQAADAV LSLLGRSPSL
Length:380
Mass (Da):41,591
Last modified:June 7, 2005 - v1
Checksum:i690FF9C3B3BA5553
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY36407.1.
RefSeqiWP_011266979.1. NC_007005.1.
YP_234445.1. NC_007005.1.

Genome annotation databases

EnsemblBacteriaiAAY36407; AAY36407; Psyr_1356.
GeneIDi3366851.
KEGGipsb:Psyr_1356.
PATRICi19983203. VBIPseSyr42314_1389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY36407.1 .
RefSeqi WP_011266979.1. NC_007005.1.
YP_234445.1. NC_007005.1.

3D structure databases

ProteinModelPortali Q4ZWR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205918.Psyr_1356.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY36407 ; AAY36407 ; Psyr_1356 .
GeneIDi 3366851.
KEGGi psb:Psyr_1356.
PATRICi 19983203. VBIPseSyr42314_1389.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PSYR205918:GJ94-1376-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B728a.

Entry informationi

Entry nameiLPXB_PSEU2
AccessioniPrimary (citable) accession number: Q4ZWR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 7, 2005
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3