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Q4ZWR5

- LPXB_PSEU2

UniProt

Q4ZWR5 - LPXB_PSEU2

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPSYR205918:GJ94-1376-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Psyr_1356
    OrganismiPseudomonas syringae pv. syringae (strain B728a)
    Taxonomic identifieri205918 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
    ProteomesiUP000000426: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Lipid-A-disaccharide synthasePRO_0000255210Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205918.Psyr_1356.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ZWR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4ZWR5-1 [UniParc]FASTAAdd to Basket

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    MPSPLCIALV AGEASGDILG SGLMRALKVR HPDIRFIGVG GPLMEAEGMQ    50
    SSFPMERLSV MGLVEVLGRL RELLARRKLL VQTLINEKPD VFIGIDAPDF 100
    TLNIELQLRR AGIKTVHYVS PSVWAWRQKR VLKIREGCDL MLTLLPFEAR 150
    FYEEQGVPVR FVGHPLADTI PLESDRAGAR AGLGLAQETP VVALMPGSRG 200
    GEVGRLGGLF FDTAERLLAR CPELRFVLPC ASPQRRAQVE QLLQGRDLPV 250
    TLLDGQSHVA LAACDAVLIA SGTATLEALL YKRPMVVAYR LAPLTFWILK 300
    RMVKSPYVSL PNLLAQRLLV PELLQDDATP EALARTLLPL IDDGREQTAG 350
    FDAIHRILRR DASNQAADAV LSLLGRSPSL 380
    Length:380
    Mass (Da):41,591
    Last modified:June 7, 2005 - v1
    Checksum:i690FF9C3B3BA5553
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000075 Genomic DNA. Translation: AAY36407.1.
    RefSeqiWP_011266979.1. NC_007005.1.
    YP_234445.1. NC_007005.1.

    Genome annotation databases

    EnsemblBacteriaiAAY36407; AAY36407; Psyr_1356.
    GeneIDi3366851.
    KEGGipsb:Psyr_1356.
    PATRICi19983203. VBIPseSyr42314_1389.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000075 Genomic DNA. Translation: AAY36407.1 .
    RefSeqi WP_011266979.1. NC_007005.1.
    YP_234445.1. NC_007005.1.

    3D structure databases

    ProteinModelPortali Q4ZWR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205918.Psyr_1356.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY36407 ; AAY36407 ; Psyr_1356 .
    GeneIDi 3366851.
    KEGGi psb:Psyr_1356.
    PATRICi 19983203. VBIPseSyr42314_1389.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PSYR205918:GJ94-1376-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B728a.

    Entry informationi

    Entry nameiLPXB_PSEU2
    AccessioniPrimary (citable) accession number: Q4ZWR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3