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Protein

NAD kinase

Gene

nadK

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton acceptorUniRule annotation1
Binding sitei157NADUniRule annotation1
Binding sitei174NADUniRule annotation1
Binding sitei176NADUniRule annotation1
Binding sitei247NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 73NADUniRule annotation2
Nucleotide bindingi146 – 147NADUniRule annotation2
Nucleotide bindingi187 – 192NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPSYR205918:G1G4J-1715-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Psyr_1685
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
Proteomesi
  • UP000000426 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296811 – 296NAD kinaseAdd BLAST296

Proteomic databases

PRIDEiQ4ZVT9

Interactioni

Protein-protein interaction databases

STRINGi205918.Psyr_1685

Structurei

3D structure databases

ProteinModelPortaliQ4ZVT9
SMRiQ4ZVT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q4ZVT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQFRNIGII GRLGSVQVLE TVRRLKRFLL DRHLHVILEE TIAEVLPGHG
60 70 80 90 100
LQTSSRKMLG EVCDMVIVVG GDGSLLGAAR ALARHNVPVL GINRGSLGFL
110 120 130 140 150
TDIRPDELEV KCAEVLDGHY LVENRFLLQA EVRRHGEAIG QGDALNDVVL
160 170 180 190 200
HPGKSTRMIE FEIYIDGQFV CSQKADGLIV ATPTGSTAYA LSAGGPIMHP
210 220 230 240 250
KLDAIVIVPM YPHTLSGRPI VVDGNSELKI VVSKDMTIYP QVSCDGQNHF
260 270 280 290
TCAPGDTITV SKKPQKLRLI HPLDHNYYEV CRTKLGWGSK LGGGGD
Length:296
Mass (Da):32,241
Last modified:June 7, 2005 - v1
Checksum:iA486A7C2B7AD6CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000075 Genomic DNA Translation: AAY36733.1
RefSeqiWP_003409651.1, NC_007005.1
YP_234771.1, NC_007005.1

Genome annotation databases

EnsemblBacteriaiAAY36733; AAY36733; Psyr_1685
GeneIDi3367190
KEGGipsb:Psyr_1685
PATRICifig|205918.7.peg.1724

Similar proteinsi

Entry informationi

Entry nameiNADK_PSEU2
AccessioniPrimary (citable) accession number: Q4ZVT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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