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Q4ZU60

- GCH4_PSEU2

UniProt

Q4ZU60 - GCH4_PSEU2

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei156 – 1561May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPSYR205918:GJ94-2309-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Psyr_2269
    OrganismiPseudomonas syringae pv. syringae (strain B728a)
    Taxonomic identifieri205918 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
    ProteomesiUP000000426: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301GTP cyclohydrolase FolE2PRO_0000289512Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205918.Psyr_2269.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ZU60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiQNLMYVE.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4ZU60-1 [UniParc]FASTAAdd to Basket

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    MNKPLPDVAL TEISPALVSL DWVGMQGVEV PIRLAEASIR HPVHAHVDLQ    50
    VDLADPSVKG IHMSRLYRLL DGYAERQIVS PDTLAALLEA MVESHLDCHS 100
    SHARLTLSFN LLCRRPALIT EGLSGWKSYP VKLDATWHAG RLCLDSSVDI 150
    TYSSTCPCSA ALSRQLLEEA FAARFGRQSF VDPMQVATWL RENASFATPH 200
    SQRSVATVQV RVAEQAAELG LMTLIDLVEQ ALGTPVQTAV KRADEQAFAR 250
    LNGQNLMYVE DAARKVQQAL EGRYAASSVS VRHFESLHPH DAAAQTSNYL 300
    S 301
    Length:301
    Mass (Da):33,019
    Last modified:June 7, 2005 - v1
    Checksum:i99EA9C812533D75E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000075 Genomic DNA. Translation: AAY37312.1.
    RefSeqiYP_235350.1. NC_007005.1.

    Genome annotation databases

    EnsemblBacteriaiAAY37312; AAY37312; Psyr_2269.
    GeneIDi3367784.
    KEGGipsb:Psyr_2269.
    PATRICi19985103. VBIPseSyr42314_2320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000075 Genomic DNA. Translation: AAY37312.1 .
    RefSeqi YP_235350.1. NC_007005.1.

    3D structure databases

    ProteinModelPortali Q4ZU60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205918.Psyr_2269.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY37312 ; AAY37312 ; Psyr_2269 .
    GeneIDi 3367784.
    KEGGi psb:Psyr_2269.
    PATRICi 19985103. VBIPseSyr42314_2320.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi QNLMYVE.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci PSYR205918:GJ94-2309-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B728a.

    Entry informationi

    Entry nameiGCH4_PSEU2
    AccessioniPrimary (citable) accession number: Q4ZU60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3