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Q4ZU60

- GCH4_PSEU2

UniProt

Q4ZU60 - GCH4_PSEU2

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPSYR205918:GJ94-2309-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Psyr_2269
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
ProteomesiUP000000426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301GTP cyclohydrolase FolE2PRO_0000289512Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205918.Psyr_2269.

Structurei

3D structure databases

ProteinModelPortaliQ4ZU60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiQNLMYVE.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ZU60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKPLPDVAL TEISPALVSL DWVGMQGVEV PIRLAEASIR HPVHAHVDLQ
60 70 80 90 100
VDLADPSVKG IHMSRLYRLL DGYAERQIVS PDTLAALLEA MVESHLDCHS
110 120 130 140 150
SHARLTLSFN LLCRRPALIT EGLSGWKSYP VKLDATWHAG RLCLDSSVDI
160 170 180 190 200
TYSSTCPCSA ALSRQLLEEA FAARFGRQSF VDPMQVATWL RENASFATPH
210 220 230 240 250
SQRSVATVQV RVAEQAAELG LMTLIDLVEQ ALGTPVQTAV KRADEQAFAR
260 270 280 290 300
LNGQNLMYVE DAARKVQQAL EGRYAASSVS VRHFESLHPH DAAAQTSNYL

S
Length:301
Mass (Da):33,019
Last modified:June 7, 2005 - v1
Checksum:i99EA9C812533D75E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000075 Genomic DNA. Translation: AAY37312.1.
RefSeqiYP_235350.1. NC_007005.1.

Genome annotation databases

EnsemblBacteriaiAAY37312; AAY37312; Psyr_2269.
GeneIDi3367784.
KEGGipsb:Psyr_2269.
PATRICi19985103. VBIPseSyr42314_2320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000075 Genomic DNA. Translation: AAY37312.1 .
RefSeqi YP_235350.1. NC_007005.1.

3D structure databases

ProteinModelPortali Q4ZU60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205918.Psyr_2269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY37312 ; AAY37312 ; Psyr_2269 .
GeneIDi 3367784.
KEGGi psb:Psyr_2269.
PATRICi 19985103. VBIPseSyr42314_2320.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi QNLMYVE.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PSYR205918:GJ94-2309-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B728a.

Entry informationi

Entry nameiGCH4_PSEU2
AccessioniPrimary (citable) accession number: Q4ZU60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 7, 2005
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3