Reviewed, UniProtKB/Swiss-Prot Q4ZRC2 (IOLG_PSEU2)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Psyr_3268

Organism

Pseudomonas syringae pv. syringae (strain B728a) [Complete proteome] [HAMAP]

Taxonomic identifier

205918 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas syringae

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352582

Sequences

	Sequence		Length	Mass (Da)
	Q4ZRC2-1 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: F602270FF559B23A	FASTA	336	36,395
	10 20 30 40 50 60 MALKLGVIGT GAIGQDHIRR CSKTLVGSQV VAVTDINLEQ AAKVVRDLDL GAEVYADGHA 70 80 90 100 110 120 LIAAPDVEAV LVCSWGPSHE EYVLAAIAAG KPVFCEKPLA VTAEGCRHIV EAEIASGRRL 130 140 150 160 170 180 VQVGFMRPYD QGYRALKAAI DSGQIGEPLM LHCAHRNPSV GENYKTDMAI TDTLIHELNV 190 200 210 220 230 240 LRWLLDDDYV SVQVVFPRKT SKALAHLKDP QIVMLETVKG TRIDVEVFVN CQYGYDIQCE 250 260 270 280 290 300 VVGETGIARL PEPSQVQLRS EAKLSNAILM DWKDRFIAAY DVELQDFIDG VKGGTLYGPS 310 320 330 AWDGYAAAVA ADACVLAQNT GAVVPITLAM RPVFYS

References

[1]

"Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000." Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A., Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S., Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M., Kyrpides N.C., Ivanova N., Lindow S.E. Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005) [PubMed: 16043691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000075 Genomic DNA. Translation: AAY38300.1.
RefSeq	YP_236338.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4ZRC2.
Genome annotation databases
GeneID	3368795.
GenomeReviews	Gene locus Psyr_3268 in contig CP000075_GR.
KEGG	psb:Psyr_3268.
NMPDR	fig|205918.4.peg.3563.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4ZRC2.
OMA	DWKDRFI.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_PSEU2

Accession

Primary (citable) accession number: Q4ZRC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	June 7, 2005
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)