Q4ZRC2 (IOLG_PSEU2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Psyr_3268

Organism

Pseudomonas syringae pv. syringae (strain B728a) [Complete proteome] [HAMAP]

Taxonomic identifier

205918 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas syringae

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352582

Sequences

	Sequence		Length	Mass (Da)
	Q4ZRC2 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: F602270FF559B23A	FASTA	336	36,395
	10 20 30 40 50 60 MALKLGVIGT GAIGQDHIRR CSKTLVGSQV VAVTDINLEQ AAKVVRDLDL GAEVYADGHA 70 80 90 100 110 120 LIAAPDVEAV LVCSWGPSHE EYVLAAIAAG KPVFCEKPLA VTAEGCRHIV EAEIASGRRL 130 140 150 160 170 180 VQVGFMRPYD QGYRALKAAI DSGQIGEPLM LHCAHRNPSV GENYKTDMAI TDTLIHELNV 190 200 210 220 230 240 LRWLLDDDYV SVQVVFPRKT SKALAHLKDP QIVMLETVKG TRIDVEVFVN CQYGYDIQCE 250 260 270 280 290 300 VVGETGIARL PEPSQVQLRS EAKLSNAILM DWKDRFIAAY DVELQDFIDG VKGGTLYGPS 310 320 330 AWDGYAAAVA ADACVLAQNT GAVVPITLAM RPVFYS

References

[1]

"Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000." Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A., Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S., Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M., Kyrpides N.C., Ivanova N., Lindow S.E. Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005) [PubMed: 16043691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B728a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000075 Genomic DNA. Translation: AAY38300.1.
RefSeq	YP_236338.1. NC_007005.1.
3D structure databases
ProteinModelPortal	Q4ZRC2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4ZRC2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3368795.
GenomeReviews	Gene locus Psyr_3268 in contig CP000075_GR.
KEGG	psb:Psyr_3268.
NMPDR	fig|205918.4.peg.3563.
PATRIC	19987172. VBIPseSyr42314_3342.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK2757149.
Enzyme and pathway databases
BioCyc	PSYR205918:PSYR_3268-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_PSEU2

Accession

Primary (citable) accession number: Q4ZRC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	June 7, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program