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Q4ZR64

- HGD_PSEU2

UniProt

Q4ZR64 - HGD_PSEU2

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei289 – 2891Proton acceptorUniRule annotation
    Metal bindingi332 – 3321IronUniRule annotation
    Metal bindingi338 – 3381IronUniRule annotation
    Binding sitei347 – 3471homogentisateUniRule annotation
    Metal bindingi368 – 3681IronUniRule annotation
    Binding sitei368 – 3681homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciPSYR205918:GJ94-3378-MONOMER.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Ordered Locus Names:Psyr_3326
    OrganismiPseudomonas syringae pv. syringae (strain B728a)
    Taxonomic identifieri205918 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
    ProteomesiUP000000426: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Homogentisate 1,2-dioxygenasePRO_1000019536Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi205918.Psyr_3326.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiFQSPVAC.
    OrthoDBiEOG6D5FZK.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4ZR64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIHSSSDAL VYQSGFGNQF SSEALPDALP VGQNSPQKHP LGLYAEQFSG    50
    TAFTVARSEA RRTWLYRIKP SAAHSRYQRM DRQMAGQEPG PINPNRLRWN 100
    AFDIPAAPTD FIDGLIPLAS TSAAEQAEGV SVYLYTANTS MQRAFFSADG 150
    EWLVVPQQGR LRIVTELGLL DIEPLEIAVL PRGLKFCVQL LDSSARGYLC 200
    ENHGCALRLP ELGPIGSNGL ANSRDFLTPV AWFEDSRQPM QLVQKFLGEL 250
    WSTQLEHSPF DVVGWHGNNV PYKYDLRRFN TIGTVSYDHP DPSIFTVLTS 300
    PGAIHGQANI DFVIFPPRWM VAENTFRPPW FHRNLMNEFM GLIDGAYDAK 350
    AEGFMPGGAS LHNCMSAHGP DNVTAEKAIA AELKPHRIDN TMAFMFETGK 400
    VLRPSRHALD CPQLQTDYDA CWKDMARTFT QEPR 434
    Length:434
    Mass (Da):48,391
    Last modified:June 7, 2005 - v1
    Checksum:iDD5AC35417020D4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000075 Genomic DNA. Translation: AAY38358.1.
    RefSeqiYP_236396.1. NC_007005.1.

    Genome annotation databases

    EnsemblBacteriaiAAY38358; AAY38358; Psyr_3326.
    GeneIDi3368853.
    KEGGipsb:Psyr_3326.
    PATRICi19987294. VBIPseSyr42314_3404.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000075 Genomic DNA. Translation: AAY38358.1 .
    RefSeqi YP_236396.1. NC_007005.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205918.Psyr_3326.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY38358 ; AAY38358 ; Psyr_3326 .
    GeneIDi 3368853.
    KEGGi psb:Psyr_3326.
    PATRICi 19987294. VBIPseSyr42314_3404.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi FQSPVAC.
    OrthoDBi EOG6D5FZK.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    BioCyci PSYR205918:GJ94-3378-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B728a.

    Entry informationi

    Entry nameiHGD_PSEU2
    AccessioniPrimary (citable) accession number: Q4ZR64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3