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Q4ZNV9

- HISX_PSEU2

UniProt

Q4ZNV9 - HISX_PSEU2

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Protein
Histidinol dehydrogenase
Gene
hisD, Psyr_4133
Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NAD By similarity
Binding sitei197 – 1971NAD By similarity
Binding sitei220 – 2201NAD By similarity
Binding sitei243 – 2431Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Metal bindingi268 – 2681Zinc By similarity
Binding sitei268 – 2681Substrate By similarity
Active sitei333 – 3331Proton acceptor By similarity
Active sitei334 – 3341Proton acceptor By similarity
Binding sitei334 – 3341Substrate By similarity
Metal bindingi367 – 3671Zinc By similarity
Binding sitei367 – 3671Substrate By similarity
Binding sitei421 – 4211Substrate By similarity
Metal bindingi426 – 4261Zinc By similarity
Binding sitei426 – 4261Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPSYR205918:GJ94-4195-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Psyr_4133
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
ProteomesiUP000000426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Histidinol dehydrogenaseUniRule annotation
PRO_0000135823Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205918.Psyr_4133.

Structurei

3D structure databases

ProteinModelPortaliQ4ZNV9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ZNV9-1 [UniParc]FASTAAdd to Basket

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MTTPTAIRRL DAADPDFARH LDHLLSWESV SDDSVNQRVL DIIKAVRERG    50
DAALVEFTQK FDGLQVASMA DLILPRERLE LALTRITPGQ REALEKAAER 100
VRSYHEKQKQ DSWSYTEADG TVLGQKVTPL DRAGLYVPGG KASYPSSVLM 150
NAIPAKVAGV TEVVMVVPTP RGEINELVLA AACIAGVDRV FTIGGAQAVA 200
ALAYGTESVP KVDKVVGPGN IYVATAKRHV FGQVGIDMIA GPSEILVVCD 250
GQTDPDWIAM DLFSQAEHDE DAQAILVSPD AEFLDKVAAS ITRLLPTMER 300
AAIVETSING RGALIKVADM AQAIEVANRI APEHLELSVA DPEAWLPQIR 350
HAGAIFMGRH TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII 400
YCSPQGASEL GKTASVLARG ESLSGHARSA EYRITDPDWT AGNKEDGK 448
Length:448
Mass (Da):48,073
Last modified:June 7, 2005 - v1
Checksum:i719C1316F740E440
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY39163.1.
RefSeqiYP_237201.1. NC_007005.1.

Genome annotation databases

EnsemblBacteriaiAAY39163; AAY39163; Psyr_4133.
GeneIDi3369670.
KEGGipsb:Psyr_4133.
PATRICi19989010. VBIPseSyr42314_4253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY39163.1 .
RefSeqi YP_237201.1. NC_007005.1.

3D structure databases

ProteinModelPortali Q4ZNV9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 205918.Psyr_4133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY39163 ; AAY39163 ; Psyr_4133 .
GeneIDi 3369670.
KEGGi psb:Psyr_4133.
PATRICi 19989010. VBIPseSyr42314_4253.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PSYR205918:GJ94-4195-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B728a.

Entry informationi

Entry nameiHISX_PSEU2
AccessioniPrimary (citable) accession number: Q4ZNV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 7, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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