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Q4ZN90

- SYL_PSEU2

UniProt

Q4ZN90 - SYL_PSEU2

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Protein
Leucine--tRNA ligase
Gene
leuS, Psyr_4352
Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei630 – 6301ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPSYR205918:GJ94-4417-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Psyr_4352
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
ProteomesiUP000000426: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 868868Leucine--tRNA ligaseUniRule annotation
PRO_1000009401Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi205918.Psyr_4352.

Structurei

3D structure databases

ProteinModelPortaliQ4ZN90.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi627 – 6315"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ZN90-1 [UniParc]FASTAAdd to Basket

« Hide

MHELYQPREI EAAAQTFWDE QKSFEVSEQP GKDTFYCLSM FPYPSGKLHM    50
GHVRNYTIGD VISRYQRMLG KNVLQPLGWD AFGMPAENAA IDNNVAPAKW 100
TYENIDYMKT QLKSLGLAVD WSREVTTCKP DYYRWEQWLF TRLFEKGVIY 150
RKNGTVNWDP IDQTVLANEQ VIDGRGWRSG ALIEKREIPM YYFKITAYAD 200
ELLESLDELP GWPEQVKTMQ RNWIGRSRGM EVQFPYDQAS IGEAGALKVF 250
TTRPDTLMGA TYVAVAAEHP LATLAAQGNP ALQAFIDECK GGSVAEADVA 300
TQEKKGQATS LFVEHPLTGE KLPVWVANYV LMHYGDGAVM AVPAHDERDF 350
EFATQYGLPI KPVVRTSAGD QTPAPWQPAY GEHGELINSG EFTGLTFQDA 400
FDAIEAALVK KSLGQSRTQF RLRDWGISRQ RYWGCPIPIV HCDTCGDVPV 450
PEDQLPVVLP EDVVPDGAGS PLARMPEFYE CSCPKCGAPA KRETDTMDTF 500
VESSWYYARY ASPHYEGGLV EPNAANHWLP VDQYIGGIEH AILHLLYARF 550
FHKLMRDEGL VTSNEPFKNL LTQGMVNAET YFRMETSGKK TWINPADVTL 600
ERDAKAKVIS ARLTSDGLPV EIGGTEKMSK SKKNGIDPQT MIDQYGADTC 650
RLFMMFASPP DMSLEWSDSG VEGSHRFLRR VWRLAQAHVT QGPSTGLDVA 700
ALSDEQKAIR RAIHQAIRQA SQDIGQNQKF NTAVAQVMTL MNVLEKAPQD 750
TPQDRALMQE GVETVALLLA PITPHISHEL WKQLGHNEPV IDAGWPAFDA 800
SALVQDSLQL VIQVNGKLRG HIEMPASASR EEVEAAARVN ENVLRFTDGL 850
TIRKVIVVPG KLVNIVAS 868
Length:868
Mass (Da):96,923
Last modified:June 7, 2005 - v1
Checksum:i58F1A797A5E213A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY39382.1.
RefSeqiYP_237420.1. NC_007005.1.

Genome annotation databases

EnsemblBacteriaiAAY39382; AAY39382; Psyr_4352.
GeneIDi3369892.
KEGGipsb:Psyr_4352.
PATRICi19989493. VBIPseSyr42314_4492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY39382.1 .
RefSeqi YP_237420.1. NC_007005.1.

3D structure databases

ProteinModelPortali Q4ZN90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205918.Psyr_4352.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY39382 ; AAY39382 ; Psyr_4352 .
GeneIDi 3369892.
KEGGi psb:Psyr_4352.
PATRICi 19989493. VBIPseSyr42314_4492.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PSYR205918:GJ94-4417-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B728a.

Entry informationi

Entry nameiSYL_PSEU2
AccessioniPrimary (citable) accession number: Q4ZN90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 7, 2005
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi