Reviewed, UniProtKB/Swiss-Prot Q4ZM63 (BETA_PSEU2)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	Psyr_4732

Organism

Pseudomonas syringae pv. syringae (strain B728a) [Complete proteome] [HAMAP]

Taxonomic identifier

205918 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas syringae

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	Choline dehydrogenase HAMAP MF_00750		PRO_0000258931
Regions
	Nucleotide binding	8 – 37	30	FAD Probable
Sites
	Active site	477	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4ZM63-1 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: 0599E772ECC67051	FASTA	568	62,690
	10 20 30 40 50 60 MTTQSEYDYI IIGAGSAGNT LAARLTEDAG VTVLLLEAGG PDYRLDFRTQ MPAALAFPLQ 70 80 90 100 110 120 GRRYNWAYET EPEPHMNNRR MECGRGKGLG GSSLINGMCY IRGNAMDYDG WAKEPGLEDW 130 140 150 160 170 180 SYLDCLPYFR KAETRDIGPN DYHGGEGPVS VTTPKAGNNP LFHAMVEAGV QAGFPRTDDL 190 200 210 220 230 240 NGYQQEGFGP MDRTVTPNGR RASTARGYLD EAKKRSTLTI VTHALTDRIL FEGKRAVGVA 250 260 270 280 290 300 YLVGDSDTRI QARARKEVLL CGGAIASPQI LQRSGVGPAE VLNKLDIPVV HDLPGVGQNL 310 320 330 340 350 360 QDHLEMYLQY ACTQPVSLYP SLKWWNQPAI GAEWMFLGTG IGASNQFEAG GFIRSSEAFE 370 380 390 400 410 420 WPNIQYHFLP VAINYNGTKG VQEHGFQAHV GSMRSPSRGR VQVKSKDPRE YPSILFNYMA 430 440 450 460 470 480 SEQDWQEFRD GIRLTREIMQ QPALDPYRGR EISPGIDVQS DEALDQFVRE HAETAYHPSC 490 500 510 520 530 540 SCKMGTDEMA VVDGQGRVHG LQSLRVVDAS IMPIITTGNL NAPTIMIAEK IADKIRGRQP 550 560 LPRSTADYFV AGDKPARGKP LREISHQA

References

[1]

"Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000." Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A., Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S., Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M., Kyrpides N.C., Ivanova N., Lindow S.E. Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005) [PubMed: 16043691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000075 Genomic DNA. Translation: AAY39759.1.
RefSeq	YP_237797.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4ZM63.
Genome annotation databases
GeneID	3370282.
GenomeReviews	Gene locus Psyr_4732 in contig CP000075_GR.
KEGG	psb:Psyr_4732.
NMPDR	fig|205918.4.peg.3795.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4ZM63.
OMA	PNLQYHF.
Enzyme and pathway databases
BioCyc	PSYR205918:PSYR_4732-MON.
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_PSEU2

Accession

Primary (citable) accession number: Q4ZM63

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	June 7, 2005
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)