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Q4ZM62

- BETB_PSEU2

UniProt

Q4ZM62 - BETB_PSEU2

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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene
betB, Psyr_4733
Organism
Pseudomonas syringae pv. syringae (strain B728a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Potassium 1; via carbonyl oxygen By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei162 – 1621Charge relay system By similarity
Metal bindingi180 – 1801Potassium 1; via carbonyl oxygen By similarity
Binding sitei209 – 2091NAD/NADP; via amide nitrogen By similarity
Metal bindingi246 – 2461Potassium 2; via carbonyl oxygen By similarity
Sitei248 – 2481Seems to be a necessary countercharge to the potassium cations By similarity
Active sitei252 – 2521Proton acceptor By similarity
Binding sitei286 – 2861NAD/NADP By similarity
Binding sitei387 – 3871NAD/NADP By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Metal bindingi460 – 4601Potassium 2; via carbonyl oxygen By similarity
Active sitei464 – 4641Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADP By similarity
Nucleotide bindingi176 – 1794NAD/NADP By similarity
Nucleotide bindingi229 – 2346NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciPSYR205918:GJ94-4808-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:Psyr_4733
OrganismiPseudomonas syringae pv. syringae (strain B728a)
Taxonomic identifieri205918 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas syringae
ProteomesiUP000000426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotationPRO_0000056551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei286 – 2861Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi205918.Psyr_4733.

Structurei

3D structure databases

ProteinModelPortaliQ4ZM62.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCTDEMTI.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ZM62-1 [UniParc]FASTAAdd to Basket

« Hide

MARFELQKLY IDGGYVDASN PETFDAINPA NGEVLAQIQR AGKDDVERAV    50
VAAEKGQKIW AAMTAVERSR ILRRAVDILR ERNDELAALE TLDTGKAISE 100
TRYVDIVTGA DVLEYYAGLV PAIEGEQIPL RDSSFVYTRR EPLGVVAGIG 150
AWNYPIQIAL WKSAPALAAG NAMIFKPSEV TSLTTLKLAE IYTEAGVPNG 200
VFNVLTGSGR EVGTWITEHP RIEKVSFTGG TDTGKKVMAS ASSSSLKEVT 250
MELGGKSPLI VFDDADLDRA ADIAMMANFY SSGQVCTNGT RVFVPNALKA 300
EFEAKILERV KRIRAGNPED ENINFGPLVS FEHMESVLGY IAKGKEQGAR 350
LLCGGDRLTG GVFDKGAFVA PTVFTDCTDE MTIVREEIFG PVMSILGYDT 400
EDEVVRRAND TDFGLAAGIV TRDLNRAHRV IHLLEAGICW INAWGESAAQ 450
MPVGGYKQSG VGRENGISSL AQYTRIKSVQ IELGDYASVF 490
Length:490
Mass (Da):53,125
Last modified:June 7, 2005 - v1
Checksum:iDDFB50825779A784
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY39760.1.
RefSeqiYP_237798.1. NC_007005.1.

Genome annotation databases

EnsemblBacteriaiAAY39760; AAY39760; Psyr_4733.
GeneIDi3370283.
KEGGipsb:Psyr_4733.
PATRICi19990289. VBIPseSyr42314_4881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000075 Genomic DNA. Translation: AAY39760.1 .
RefSeqi YP_237798.1. NC_007005.1.

3D structure databases

ProteinModelPortali Q4ZM62.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205918.Psyr_4733.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY39760 ; AAY39760 ; Psyr_4733 .
GeneIDi 3370283.
KEGGi psb:Psyr_4733.
PATRICi 19990289. VBIPseSyr42314_4881.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CTDEMTI.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci PSYR205918:GJ94-4808-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B728a.

Entry informationi

Entry nameiBETB_PSEU2
AccessioniPrimary (citable) accession number: Q4ZM62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 7, 2005
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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