Reviewed, UniProtKB/Swiss-Prot Q4ZM62 (BETB_PSEU2)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Psyr_4733

Organism

Pseudomonas syringae pv. syringae (strain B728a) [Complete proteome] [HAMAP]

Taxonomic identifier

205918 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas syringae

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056551
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4ZM62-1 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: DDFB50825779A784	FASTA	490	53,125
	10 20 30 40 50 60 MARFELQKLY IDGGYVDASN PETFDAINPA NGEVLAQIQR AGKDDVERAV VAAEKGQKIW 70 80 90 100 110 120 AAMTAVERSR ILRRAVDILR ERNDELAALE TLDTGKAISE TRYVDIVTGA DVLEYYAGLV 130 140 150 160 170 180 PAIEGEQIPL RDSSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTTLKLAE IYTEAGVPNG VFNVLTGSGR EVGTWITEHP RIEKVSFTGG TDTGKKVMAS 250 260 270 280 290 300 ASSSSLKEVT MELGGKSPLI VFDDADLDRA ADIAMMANFY SSGQVCTNGT RVFVPNALKA 310 320 330 340 350 360 EFEAKILERV KRIRAGNPED ENINFGPLVS FEHMESVLGY IAKGKEQGAR LLCGGDRLTG 370 380 390 400 410 420 GVFDKGAFVA PTVFTDCTDE MTIVREEIFG PVMSILGYDT EDEVVRRAND TDFGLAAGIV 430 440 450 460 470 480 TRDLNRAHRV IHLLEAGICW INAWGESAAQ MPVGGYKQSG VGRENGISSL AQYTRIKSVQ 490 IELGDYASVF

References

[1]

"Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000." Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A., Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S., Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M., Kyrpides N.C., Ivanova N., Lindow S.E. Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005) [PubMed: 16043691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000075 Genomic DNA. Translation: AAY39760.1.
RefSeq	YP_237798.1.
3D structure databases
SMR	Q4ZM62. Positions 8-490.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4ZM62.
Genome annotation databases
GeneID	3370283.
GenomeReviews	Gene locus Psyr_4733 in contig CP000075_GR.
KEGG	psb:Psyr_4733.
NMPDR	fig|205918.4.peg.3796.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	TDCRDEM.
Enzyme and pathway databases
BioCyc	PSYR205918:PSYR_4733-MONOMER.
Family and domain databases
HAMAP	MF_00804. BADH. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_PSEU2

Accession

Primary (citable) accession number: Q4ZM62

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	June 7, 2005
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)