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Protein

Complement C1q and tumor necrosis factor-related protein 9

Gene

C1qtnf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.1 Publication

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q and tumor necrosis factor-related protein 9
Gene namesi
Name:C1qtnf9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3045252. C1qtnf9.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi23 – 231C → A: No change in the interaction with ADIPOQ. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 333314Complement C1q and tumor necrosis factor-related protein 9PRO_0000291752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 3114-hydroxyproline1 Publication
Modified residuei34 – 3414-hydroxyproline1 Publication
Modified residuei40 – 4014-hydroxyproline1 Publication
Modified residuei58 – 5814-hydroxyproline1 Publication
Modified residuei61 – 6114-hydroxyproline1 Publication
Modified residuei64 – 6414-hydroxyproline1 Publication
Modified residuei73 – 7315-hydroxylysine1 Publication
Glycosylationi73 – 731O-linked (Gal...)1 Publication
Modified residuei76 – 7614-hydroxyproline1 Publication
Modified residuei115 – 11514-hydroxyproline1 Publication
Modified residuei127 – 12715-hydroxylysine1 Publication
Glycosylationi127 – 1271O-linked (Gal...)1 Publication
Modified residuei151 – 15114-hydroxyproline1 Publication
Modified residuei160 – 16014-hydroxyproline1 Publication
Modified residuei175 – 17514-hydroxyproline1 Publication

Post-translational modificationi

The isomeric forms of the hydroxylated amino acids could not be determined in the mass-spectrometric methods reported in PubMed:18787108 but are assumed on the basis of their occurrence in collagen-like domains.1 Publication

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ4ZJN1.
PaxDbiQ4ZJN1.
PRIDEiQ4ZJN1.
TopDownProteomicsiQ4ZJN1-1. [Q4ZJN1-1]

Expressioni

Tissue specificityi

Expressed predominantly in adipose tissue. Females express higher levels than males.1 Publication

Gene expression databases

BgeeiQ4ZJN1.
CleanExiMM_C1QTNF9.
GenevisibleiQ4ZJN1. MM.

Interactioni

Subunit structurei

Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex.1 Publication

Protein-protein interaction databases

IntActiQ4ZJN1. 1 interaction.
STRINGi10090.ENSMUSP00000025940.

Structurei

3D structure databases

ProteinModelPortaliQ4ZJN1.
SMRiQ4ZJN1. Positions 197-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8259Collagen-like 1Add
BLAST
Domaini84 – 13047Collagen-like 2Add
BLAST
Domaini134 – 19360Collagen-like 3Add
BLAST
Domaini197 – 333137C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 3 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IE67. Eukaryota.
ENOG4112BCC. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ4ZJN1.
OMAiICMGNVN.
OrthoDBiEOG70ZZPW.
PhylomeDBiQ4ZJN1.
TreeFamiTF334029.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 3 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4ZJN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRIWWLLLVM GACTRSVFSQ DTCRQGHSGI PGNPGHNGLP GRDGRDGAKG
60 70 80 90 100
DKGDAGEPGH PGGPGKDGIR GEKGEPGADG RVEAKGIKGD PGSRGSPGKH
110 120 130 140 150
GPKGSIGPTG EQGLPGETGP QGQKGDKGEV GPTGPEGLMG STGPLGPKGL
160 170 180 190 200
PGPMGPIGKP GPRGEAGPMG PQGEPGVRGM RGWKGDRGEK GKVGEAPLVP
210 220 230 240 250
KSAFTVGLTV ISKFPPPDAP IKFDKILYNE LNHYNVATGK FTCHVAGVYY
260 270 280 290 300
FTYHITVFSR NVQVSLVKNG VKVLHTKDSY MSSEDQASGG IVQELKLGDE
310 320 330
VWMQVTGGER FNGLFADEDD DTTFTGFLLF SSS
Length:333
Mass (Da):34,566
Last modified:June 7, 2005 - v1
Checksum:i7F68661C0A6841F3
GO
Isoform 2 (identifier: Q4ZJN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:195
Mass (Da):20,854
Checksum:iA4114D33233475EE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 138138Missing in isoform 2. 1 PublicationVSP_026218Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002401 mRNA. Translation: AAY21933.1.
AK033673 mRNA. Translation: BAC28422.1.
BC115632 mRNA. Translation: AAI15633.1.
BC115633 mRNA. Translation: AAI15634.1.
CCDSiCCDS27178.1. [Q4ZJN1-1]
RefSeqiNP_898998.2. NM_183175.4. [Q4ZJN1-1]
XP_006519046.1. XM_006518983.2. [Q4ZJN1-2]
XP_006519047.1. XM_006518984.2. [Q4ZJN1-2]
UniGeneiMm.319636.

Genome annotation databases

EnsembliENSMUST00000025940; ENSMUSP00000025940; ENSMUSG00000071347. [Q4ZJN1-1]
GeneIDi239126.
KEGGimmu:239126.
UCSCiuc007uff.2. mouse. [Q4ZJN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002401 mRNA. Translation: AAY21933.1.
AK033673 mRNA. Translation: BAC28422.1.
BC115632 mRNA. Translation: AAI15633.1.
BC115633 mRNA. Translation: AAI15634.1.
CCDSiCCDS27178.1. [Q4ZJN1-1]
RefSeqiNP_898998.2. NM_183175.4. [Q4ZJN1-1]
XP_006519046.1. XM_006518983.2. [Q4ZJN1-2]
XP_006519047.1. XM_006518984.2. [Q4ZJN1-2]
UniGeneiMm.319636.

3D structure databases

ProteinModelPortaliQ4ZJN1.
SMRiQ4ZJN1. Positions 197-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4ZJN1. 1 interaction.
STRINGi10090.ENSMUSP00000025940.

Proteomic databases

MaxQBiQ4ZJN1.
PaxDbiQ4ZJN1.
PRIDEiQ4ZJN1.
TopDownProteomicsiQ4ZJN1-1. [Q4ZJN1-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025940; ENSMUSP00000025940; ENSMUSG00000071347. [Q4ZJN1-1]
GeneIDi239126.
KEGGimmu:239126.
UCSCiuc007uff.2. mouse. [Q4ZJN1-1]

Organism-specific databases

CTDi338872.
MGIiMGI:3045252. C1qtnf9.

Phylogenomic databases

eggNOGiENOG410IE67. Eukaryota.
ENOG4112BCC. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ4ZJN1.
OMAiICMGNVN.
OrthoDBiEOG70ZZPW.
PhylomeDBiQ4ZJN1.
TreeFamiTF334029.

Miscellaneous databases

NextBioi384003.
PROiQ4ZJN1.
SOURCEiSearch...

Gene expression databases

BgeeiQ4ZJN1.
CleanExiMM_C1QTNF9.
GenevisibleiQ4ZJN1. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 3 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of Acrp30/adiponectin structural and functional paralogs."
    Wong G.W., Wang J., Hug C., Tsao T.S., Lodish H.F.
    Proc. Natl. Acad. Sci. U.S.A. 101:10302-10307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Adipose tissue.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Cecum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin."
    Wong G.W., Krawczyk S.A., Kitidis-Mitrokostas C., Ge G., Spooner E., Hug C., Gimeno R., Lodish H.F.
    FASEB J. 23:241-258(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ADIPOQ, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION AT LYS-73 AND LYS-127, HYDROXYLATION AT PRO-31; PRO-34; PRO-40; PRO-58; PRO-61; PRO-64; LYS-73; PRO-76; PRO-115; LYS-127; PRO-151; PRO-160 AND PRO-175, MUTAGENESIS OF CYS-23, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiC1QT9_MOUSE
AccessioniPrimary (citable) accession number: Q4ZJN1
Secondary accession number(s): Q8BZS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 7, 2005
Last modified: March 16, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression of CTRP9 in obese (ob/ob) mice significantly lowered serum glucose levels.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.