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Protein

Complement C1q and tumor necrosis factor-related protein 9

Gene

C1qtnf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.1 Publication

Miscellaneous

Overexpression of CTRP9 in obese (ob/ob) mice significantly lowered serum glucose levels.

GO - Molecular functioni

  • hormone activity Source: MGI

GO - Biological processi

  • energy homeostasis Source: MGI
  • fatty acid oxidation Source: MGI
  • negative regulation of cell size Source: MGI
  • positive regulation of cellular response to insulin stimulus Source: MGI
  • positive regulation of protein serine/threonine kinase activity Source: MGI

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q and tumor necrosis factor-related protein 9
Gene namesi
Name:C1qtnf9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3045252 C1qtnf9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23C → A: No change in the interaction with ADIPOQ. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000029175220 – 333Complement C1q and tumor necrosis factor-related protein 9Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314-hydroxyproline1 Publication1
Modified residuei344-hydroxyproline1 Publication1
Modified residuei404-hydroxyproline1 Publication1
Modified residuei584-hydroxyproline1 Publication1
Modified residuei614-hydroxyproline1 Publication1
Modified residuei644-hydroxyproline1 Publication1
Modified residuei735-hydroxylysine1 Publication1
Glycosylationi73O-linked (Gal...) hydroxylysine1 Publication1
Modified residuei764-hydroxyproline1 Publication1
Modified residuei1154-hydroxyproline1 Publication1
Modified residuei1275-hydroxylysine1 Publication1
Glycosylationi127O-linked (Gal...) hydroxylysine1 Publication1
Modified residuei1514-hydroxyproline1 Publication1
Modified residuei1604-hydroxyproline1 Publication1
Modified residuei1754-hydroxyproline1 Publication1

Post-translational modificationi

The isomeric forms of the hydroxylated amino acids could not be determined in the mass-spectrometric methods reported in PubMed:18787108 but are assumed on the basis of their occurrence in collagen-like domains.1 Publication

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ4ZJN1
PRIDEiQ4ZJN1
TopDownProteomicsiQ4ZJN1-1 [Q4ZJN1-1]

PTM databases

PhosphoSitePlusiQ4ZJN1

Expressioni

Tissue specificityi

Expressed predominantly in adipose tissue. Females express higher levels than males.1 Publication

Gene expression databases

BgeeiENSMUSG00000071347
CleanExiMM_C1QTNF9
GenevisibleiQ4ZJN1 MM

Interactioni

Subunit structurei

Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex.1 Publication

GO - Molecular functioni

  • hormone activity Source: MGI

Protein-protein interaction databases

IntActiQ4ZJN1, 1 interactor
STRINGi10090.ENSMUSP00000025940

Structurei

3D structure databases

ProteinModelPortaliQ4ZJN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 82Collagen-like 1Add BLAST59
Domaini84 – 130Collagen-like 2Add BLAST47
Domaini134 – 193Collagen-like 3Add BLAST60
Domaini197 – 333C1qPROSITE-ProRule annotationAdd BLAST137

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IE67 Eukaryota
ENOG4112BCC LUCA
GeneTreeiENSGT00760000118830
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiQ4ZJN1
OMAiGMRGWKG
OrthoDBiEOG091G0L3Y
PhylomeDBiQ4ZJN1
TreeFamiTF334029

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 3 hits
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4ZJN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRIWWLLLVM GACTRSVFSQ DTCRQGHSGI PGNPGHNGLP GRDGRDGAKG
60 70 80 90 100
DKGDAGEPGH PGGPGKDGIR GEKGEPGADG RVEAKGIKGD PGSRGSPGKH
110 120 130 140 150
GPKGSIGPTG EQGLPGETGP QGQKGDKGEV GPTGPEGLMG STGPLGPKGL
160 170 180 190 200
PGPMGPIGKP GPRGEAGPMG PQGEPGVRGM RGWKGDRGEK GKVGEAPLVP
210 220 230 240 250
KSAFTVGLTV ISKFPPPDAP IKFDKILYNE LNHYNVATGK FTCHVAGVYY
260 270 280 290 300
FTYHITVFSR NVQVSLVKNG VKVLHTKDSY MSSEDQASGG IVQELKLGDE
310 320 330
VWMQVTGGER FNGLFADEDD DTTFTGFLLF SSS
Length:333
Mass (Da):34,566
Last modified:June 7, 2005 - v1
Checksum:i7F68661C0A6841F3
GO
Isoform 2 (identifier: Q4ZJN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:195
Mass (Da):20,854
Checksum:iA4114D33233475EE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0262181 – 138Missing in isoform 2. 1 PublicationAdd BLAST138

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002401 mRNA Translation: AAY21933.1
AK033673 mRNA Translation: BAC28422.1
BC115632 mRNA Translation: AAI15633.1
BC115633 mRNA Translation: AAI15634.1
CCDSiCCDS27178.1 [Q4ZJN1-1]
RefSeqiNP_898998.2, NM_183175.4 [Q4ZJN1-1]
XP_006519046.1, XM_006518983.2 [Q4ZJN1-2]
XP_006519047.1, XM_006518984.2 [Q4ZJN1-2]
UniGeneiMm.319636

Genome annotation databases

EnsembliENSMUST00000025940; ENSMUSP00000025940; ENSMUSG00000071347 [Q4ZJN1-1]
GeneIDi239126
KEGGimmu:239126
UCSCiuc007uff.2 mouse [Q4ZJN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiC1QT9_MOUSE
AccessioniPrimary (citable) accession number: Q4ZJN1
Secondary accession number(s): Q8BZS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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