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Protein

Superoxide dismutase

Gene

SOD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49Divalent metal cationUniRule annotation1
Metal bindingi97Divalent metal cationUniRule annotation1
Metal bindingi182Divalent metal cationUniRule annotation1
Metal bindingi186Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:SOD2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiQ4ZJI1

Structurei

3D structure databases

ProteinModelPortaliQ4ZJI1
SMRiQ4ZJI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 105Sod_Fe_NInterPro annotationAdd BLAST82
Domaini112 – 212Sod_Fe_CInterPro annotationAdd BLAST101

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
HOVERGENiHBG004451

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Fragment.

Q4ZJI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RHQQAAGRQA AWLPVLGYLG SRQKHSLPDL PYDYGALEPH INAQIMQLHH
60 70 80 90 100
SKHHAAYVNN LNVTEEKYQE ALAKGDVTAQ IALQPALKFN GGGHINHSIF
110 120 130 140 150
WTNLSPNGGG EPKGELLEAI KRDFGSFDKF KEKLTAASVG VQGSGWGWLG
160 170 180 190 200
FNKERGHLQI AACPNQDPLQ GTTGLIPLLG IDVWEHAYYL QYKNVRPDYL
210
KAIWNVINWE NV
Length:212
Mass (Da):23,639
Last modified:June 7, 2005 - v1
Checksum:i21E7A4A093ED3282
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei212Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ003134 mRNA Translation: AAY21807.1
UniGeneiHs.487046

Similar proteinsi

Entry informationi

Entry nameiQ4ZJI1_HUMAN
AccessioniPrimary (citable) accession number: Q4ZJI1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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