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Protein

Superoxide dismutase

Gene

SOD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:SOD2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ4ZJI1.
PRIDEiQ4ZJI1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356022.

Structurei

3D structure databases

ProteinModelPortaliQ4ZJI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10582Sod_Fe_NInterPro annotationAdd
BLAST
Domaini112 – 212101Sod_Fe_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0876. Eukaryota.
COG0605. LUCA.
HOVERGENiHBG004451.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4ZJI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RHQQAAGRQA AWLPVLGYLG SRQKHSLPDL PYDYGALEPH INAQIMQLHH
60 70 80 90 100
SKHHAAYVNN LNVTEEKYQE ALAKGDVTAQ IALQPALKFN GGGHINHSIF
110 120 130 140 150
WTNLSPNGGG EPKGELLEAI KRDFGSFDKF KEKLTAASVG VQGSGWGWLG
160 170 180 190 200
FNKERGHLQI AACPNQDPLQ GTTGLIPLLG IDVWEHAYYL QYKNVRPDYL
210
KAIWNVINWE NV
Length:212
Mass (Da):23,639
Last modified:June 7, 2005 - v1
Checksum:i21E7A4A093ED3282
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei212 – 2121Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ003134 mRNA. Translation: AAY21807.1.
UniGeneiHs.487046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ003134 mRNA. Translation: AAY21807.1.
UniGeneiHs.487046.

3D structure databases

ProteinModelPortaliQ4ZJI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356022.

Proteomic databases

PaxDbiQ4ZJI1.
PRIDEiQ4ZJI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0876. Eukaryota.
COG0605. LUCA.
HOVERGENiHBG004451.

Miscellaneous databases

ChiTaRSiSOD2. human.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of Mn-Superoxide Dismutase Gene in Nontumorigenic and Tumorigenic Human Mammary Epithelial Cells."
    Mukhopadhyay S., Das S.K., Mukherjee S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ4ZJI1_HUMAN
AccessioniPrimary (citable) accession number: Q4ZJI1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 11, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.